Ratio Statistics for Efficacy Analysis of New Drugs (50 Patients)
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Treatment efficacies are often assessed as differences from baseline. However, better treatment efficacies may be observed in patients with high baseline-values than in those with low ones. This was, e.g., the case in the Progress study, a parallel-group study of pravastatin versus placebo (see Statistics applied to clinical studies 5th edition, Chap. 17, Logistic and Cox regression, Markov models, and Laplace transformations, pp. 199–218, Springer Heidelberg Germany, 2012, from the same authors) . This chapter assesses the performance of ratio statistics for that purpose.