Ratio Statistics for Efficacy Analysis of New Drugs (50 Patients)

  • Ton J. Cleophas
  • Aeilko H. Zwinderman


Treatment efficacies are often assessed as differences from baseline. However, better treatment efficacies may be observed in patients with high baseline-values than in those with low ones. This was, e.g., the case in the Progress study, a parallel-group study of pravastatin versus placebo (see Statistics applied to clinical studies 5th edition, Chap. 17, Logistic and Cox regression, Markov models, and Laplace transformations, pp. 199–218, Springer Heidelberg Germany, 2012, from the same authors) . This chapter assesses the performance of ratio statistics for that purpose.

Supplementary material

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Ton J. Cleophas
    • 1
  • Aeilko H. Zwinderman
    • 2
  1. 1.Department Medicine Albert Schweitzer HospitalDordrechtThe Netherlands
  2. 2.Academic Medical CenterDepartment Biostatistics and EpidemiologyAmsterdamThe Netherlands

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