Deep Learning Based Approach to Quantification of PET Tracer Uptake in Small Tumors

  • Laura Dal TosoEmail author
  • Elisabeth Pfaehler
  • Ronald Boellaard
  • Julia A. Schnabel
  • Paul K. Marsden
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 11905)


In Positron Emission Tomography (PET), quantification of tumor radiotracer uptake is mainly performed using standardised uptake value and related methods. However, the accuracy of these metrics is limited by the poor spatial resolution and noise properties of PET images. Therefore, there is a great need for new methods that allow for accurate and reproducible quantification of tumor radiotracer uptake, particularly for small regions. In this work, we propose a deep learning approach to improve quantification of PET tracer uptake in small tumors using a 3D convolutional neural network. The network was trained on simulated images that present 3D shapes with typical tumor tracer uptake distributions (‘ground truth distributions’), and the corresponding set of simulated PET images. The network was tested on unseen simulated PET images and was shown to robustly estimate the original radiotracer uptake, yielding improved images both in terms of shape and activity distribution. The same network was successful when applied to 3D tumors acquired from physical phantom PET scans.


Convolutional neural network PET Quantification Reconstruction 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Laura Dal Toso
    • 1
    Email author
  • Elisabeth Pfaehler
    • 2
  • Ronald Boellaard
    • 2
    • 3
  • Julia A. Schnabel
    • 1
  • Paul K. Marsden
    • 1
  1. 1.School of Biomedical Engineering and Imaging SciencesKing’s College LondonLondonUK
  2. 2.Department of Nuclear Medicine and Molecular ImagingUniversity of Groningen, University Medical Center GroningenGroningenThe Netherlands
  3. 3.Department of Radiology and Nuclear MedicineAmsterdam University Medical CentersAmsterdamThe Netherlands

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