The Importance of Cellular Senescence in Frailty and Cardiovascular Diseases

  • Virginia BoccardiEmail author
  • Patrizia Mecocci
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1216)


Frailty is a complex clinical syndrome, progressively described in the last thirty years, resulting from multiple impairments across many organs and systems and characterized by a reduction in physiological reserves and increased vulnerability to stressors, as well. Cardiovascular diseases (CVDs) are a common health problem in very old populations. Age-related changes occur throughout the body and in all organs, including the cardiovascular system. Cellular senescence links age-related CVDs and frailty by many mechanisms of particular interest in the aging biology and geriatric syndromes. Cellular senescence may represent the pivotal factor with its senescence-associated secretory phenotype (SASP) leading to systemic inflammation. In this context, SASP may represent the key element in the association between aging, frailty and the development of age-related CVDs.


Aging Cardiovascular Comorbidities Frailty Inflammation Senescence 


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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of MedicineSanta Maria della Misericordia Hospital, Section of Gerontology and Geriatrics, University of PerugiaPerugiaItaly

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