Demographic Influences and Health Disparities

  • Carmen Mironovici
  • Maura Kepper
  • Richard Scribner
  • Stuart ChalewEmail author


Diabetes is one of the most common incurable, chronic diseases of childhood. Metabolic changes associated with diabetes are associated with development of serious acute and chronic complications with increased morbidity and mortality. The incidence and prevalence of diabetes, success in achieving optimal management, outcomes, and risk for developing later complications have been found to vary between patients of different race, ethnicity, and socioeconomic backgrounds. Disparities between race/ethnic groups have been found to have persisted or worsened despite improvements in management technology. Potentially the interplay of genetic, biological factors along with environment and socioeconomic influences contributes to continued health disparities among children with diabetes. Better understanding of factors mediating health disparities can help bring about changes in management leading to optimal outcomes for all patients.


Children Adolescents Diabetes Social determinants Environment Neighborhood Socioeconomic status Race Ethnicity Diabetes complications Health disparities Diabetes management 


  1. Abbasi, A., Juszczyk, D., van Jaarsveld, C. H. M., & Gulliford, M. C. (2017). Body mass index and incident type 1 and type 2 diabetes in children and young adults: A retrospective cohort study. Journal of the Endocrine Society, 1(5), 524–537. Scholar
  2. Acevedo-Garcia, D., Osypuk, T. L., McArdle, N., & Williams, D. R. (2008). Toward a policy-relevant analysis of geographic and racial/ethnic disparities in child health. Health Aff (Millwood), 27(2), 321–333. Scholar
  3. Alberti, G., Zimmet, P., Shaw, J., Bloomgarden, Z., Kaufman, F., Silink, M., & Consensus Workshop, G. (2004). Type 2 diabetes in the young: the evolving epidemic: The international diabetes federation consensus workshop. Diabetes Care, 27(7), 1798–1811.PubMedCrossRefGoogle Scholar
  4. Alisi, A., Locatelli, M., & Nobili, V. (2010). Nonalcoholic fatty liver disease in children. Current Opinion in Clinical Nutrition and Metabolic Care, 13(4), 397–402. Scholar
  5. American Diabetes Association (2013). Diagnosis and classification of diabetes mellitus. Diabetes Care, 36(Suppl 1), S67–S74.
  6. American Diabetes Association. (2000). Type 2 diabetes in children and adolescents. Diabetes Care, 23(3), 381–389.Google Scholar
  7. American Diabetes Association Workgroup on Hypoglycemia. (2005). Defining and reporting hypoglycemia in diabetes. A report from the American Diabetes Association Workgroup on Hypoglycemia. Diabetes Care, 28(5), 1245–1249.CrossRefGoogle Scholar
  8. Amin, R., Widmer, B., Prevost, A. T., Schwarze, P., Cooper, J., Edge, J., & Dunger, D. B. (2008). Risk of microalbuminuria and progression to macroalbuminuria in a cohort with childhood onset type 1 diabetes: Prospective observational study. BMJ, 336(7646), 697–701. Scholar
  9. Arslanian, S. A., Saad, R., Lewy, V., Danadian, K., & Janosky, J. (2002). Hyperinsulinemia in african-american children: Decreased insulin clearance and increased insulin secretion and its relationship to insulin sensitivity. Diabetes, 51(10), 3014–3019.PubMedCrossRefGoogle Scholar
  10. Astrup, A., & Finer, N. (2000). Redefining type 2 diabetes: ‘Diabesity’ or ‘obesity dependent diabetes mellitus’? Obesity Reviews, 1(2), 57–59.PubMedCrossRefGoogle Scholar
  11. Asvold, B. O., Sand, T., Hestad, K., & Bjorgaas, M. R. (2010). Cognitive function in type 1 diabetic adults with early exposure to severe hypoglycemia: A 16-year follow-up study. Diabetes Care, 33(9), 1945–1947. Scholar
  12. Baez, E. A., Shah, S., Felipe, D., Maynard, J., & Chalew, S. (2015). Correlation of advanced glycation endproducts estimated from skin fluorescence in first-degree relatives: The impact of adjustment for skin pigmentation. Journal of Diabetes Science and Technology, 9(2), 278–281. Scholar
  13. Baez, E. A., Shah, S., Felipe, D., Maynard, J., Lefevre, S., & Chalew, S. A. (2014). Skin advanced glycation endproducts are elevated at onset of type 1 diabetes in youth. Journal of Pediatric Endocrinology & Metabolism.
  14. Ball, K., Cleland, V. J., Timperio, A. F., Salmon, J., Giles-Corti, B., & Crawford, D. A. (2010). Love thy neighbour? Associations of social capital and crime with physical activity amongst women. Social Science & Medicine, 71(4), 807–814. doi:S0277-9536(10)00410-7 [pii]. Scholar
  15. Bao, X. H., Wong, V., Wang, Q., & Low, L. C. (1999). Prevalence of peripheral neuropathy with insulin-dependent diabetes mellitus. Pediatric Neurology, 20(3), 204–209.PubMedCrossRefGoogle Scholar
  16. Bateson, P., Barker, D., Clutton-Brock, T., Deb, D., D’Udine, B., Foley, R. A., & Sultan, S. E. (2004). Developmental plasticity and human health. Nature, 430(6998), 419–421. Scholar
  17. Beck, R. W., Tamborlane, W. V., Bergenstal, R. M., Miller, K. M., DuBose, S. N., Hall, C. A., & Network, T. D. E. C. (2012). The T1D exchange clinic registry. The Journal of Clinical Endocrinology and Metabolism, 97(12), 4383–4389. Scholar
  18. Bell, R. A., Mayer-Davis, E. J., Beyer, J. W., D’Agostino, R. B., Jr., Lawrence, J. M., Linder, B., & Group, S. f. D. i. Y. S. (2009). Diabetes in non-Hispanic white youth: prevalence, incidence, and clinical characteristics: The SEARCH for diabetes in youth study. Diabetes Care, 32(Suppl 2), S102–S111. Scholar
  19. Billimek, J., & Sorkin, D. H. (2012). Food insecurity, processes of care, and self-reported medication underuse in patients with type 2 diabetes: Results from the California Health Interview Survey. Health Services Research, 47(6), 2159–2168. Scholar
  20. Blair, C., Raver, C. C., Granger, D., Mills-Koonce, R., & Hibel, L. (2011). Allostasis and allostatic load in the context of poverty in early childhood. Development and Psychopathology, 23(3), 845–857. Scholar
  21. Bobo, N., Evert, A., Gallivan, J., Imperatore, G., Kelly, J., Linder, B., & Diabetes in Children Adolescents Work Group of the National Diabetes Education, P. (2004). An update on type 2 diabetes in youth from the National Diabetes Education Program. Pediatrics, 114(1), 259–263.PubMedCrossRefGoogle Scholar
  22. Bogdanovic, R. (2008). Diabetic nephropathy in children and adolescents. Pediatric Nephrology, 23(4), 507–525. Scholar
  23. Bognetti, E., Calori, G., Meschi, F., Macellaro, P., Bonfanti, R., & Chiumello, G. (1997). Prevalence and correlations of early microvascular complications in young type I diabetic patients: Role of puberty. Journal of Pediatric Endocrinology & Metabolism, 10(6), 587–592.CrossRefGoogle Scholar
  24. Bojestig, M., Arnqvist, H. J., Hermansson, G., Karlberg, B. E., & Ludvigsson, J. (1994). Declining incidence of nephropathy in insulin-dependent diabetes mellitus. The New England Journal of Medicine, 330(1), 15–18. Scholar
  25. Booker, C. (2010). The accelerator hypothesis: Insulin resistance as the central cause of type 1 and type 2 diabetes. International Journal of Obesity, 34(1), 210–211.; author reply 212. Scholar
  26. Bos, D. C., de Ranitz-Greven, W. L., & De Valk, H. W. (2011). Advanced glycation end products, measured as skin autofluorescence and diabetes complications: A systematic review. Diabetes Technology & Therapeutics, 13(7), 773–779.CrossRefGoogle Scholar
  27. Browning, J. D., Szczepaniak, L. S., Dobbins, R., Nuremberg, P., Horton, J. D., Cohen, J. C., & Hobbs, H. H. (2004). Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity. Hepatology, 40(6), 1387–1395. Scholar
  28. Brownlee, M., Cerami, A., & Vlassara, H. (1988). Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications. The New England Journal of Medicine, 318(20), 1315–1321. Scholar
  29. Brownson, R. C., Hoehner, C. M., Day, K., Forsyth, A., & Sallis, J. F. (2009). Measuring the built environment for physical activity: State of the science. American Journal of Preventive Medicine, 36(4 Suppl), S99–S123. e112. doi: Scholar
  30. Bulger, J. B., Shubrook, J. H., & Snow, R. (2012). Racial disparities in African Americans with diabetes: Process and outcome mismatch. The American Journal of Managed Care, 18(8), 407–413.PubMedGoogle Scholar
  31. Burdette, A. M., & Hill, T. D. (2008). An examination of processes linking perceived neighborhood disorder and obesity. Social Science & Medicine, 67(1), 38–46. Scholar
  32. Byers, T., Nestle, M., McTiernan, A., Doyle, C., Currie-Williams, A., Gansler, T., & Physical Activity Guidelines Advisory, C. (2002). American Cancer Society guidelines on nutrition and physical activity for cancer prevention: Reducing the risk of cancer with healthy food choices and physical activity. CA: A Cancer Journal for Clinicians, 52(2), 92–119.Google Scholar
  33. Cali, A. M., De Oliveira, A. M., Kim, H., Chen, S., Reyes-Mugica, M., Escalera, S., & Caprio, S. (2009). Glucose dysregulation and hepatic steatosis in obese adolescents: Is there a link? Hepatology, 49(6), 1896–1903. Scholar
  34. Calle, E. E., Thun, M. J., Petrelli, J. M., Rodriguez, C., & Heath, C. W., Jr. (1999). Body-mass index and mortality in a prospective cohort of U.S. adults. The New England Journal of Medicine, 341(15), 1097–1105. Scholar
  35. Carlsson, A. C., Nixon Andreasson, A., & Wandell, P. E. (2011). Poor self-rated health is not associated with a high total allostatic load in type 2 diabetic patients – but high blood pressure is. Diabetes & Metabolism, 37(5), 446–451. Scholar
  36. Carver, A., Timperio, A., Hesketh, K., & Crawford, D. (2010). Are children and adolescents less active if parents restrict their physical activity and active transport due to perceived risk? Social Science & Medicine, 70(11), 1799–1805. Scholar
  37. CDC (2014a). National Diabetes statistics report: estimates of diabetes and its burden in the United States, 2014. Atlanta, GA: US Department of Health and Human Services.Google Scholar
  38. Cengiz, E., Xing, D., Wong, J. C., Wolfsdorf, J. I., Haymond, M. W., Rewers, A., & Network, T. D. E. C. (2013). Severe hypoglycemia and diabetic ketoacidosis among youth with type 1 diabetes in the T1D Exchange clinic registry. Pediatric Diabetes, 14(6), 447–454. Scholar
  39. Centers for Disease Control & Prevention CDC (2007). Racial disparities in diabetes mortality among persons aged 1-19 years – United States, 1979-2004. MMWR. Morbidity and Mortality Weekly Report, 56(45), 1184–1187. Google Scholar
  40. Chalew, S. A. (2015). The continuing challenge of outcome disparities in children with diabetes. Pediatrics, 135(3), 552–553. Scholar
  41. Chalew, S. A., Gomez, R., Vargas, A., Kamps, J. L., Jurgen, B., Scribner, R., & Hempe, J. (2018). Hemoglobin A1c, frequence of glucose testing and social disadvantage: Metrics of racial health disparity in youth with type 1 diabetes. Journal of Diabetes and Its Complications, (accepted for publication).Google Scholar
  42. Chalew, S. A., Hempe, J. M., & McCarter, R. (2009). Clinically significant disagreement between mean blood glucose and estimated average glucose in two populations: Implications for diabetes management. Journal of Diabetes Science and Technology, 3(5), 1128–1135. Scholar
  43. Chiang, J. L., Kirkman, M. S., Laffel, L. M., Peters, A. L., & Type 1 Diabetes Sourcebook, A. (2014). Type 1 diabetes through the life span: A position statement of the American Diabetes Association. Diabetes Care, 37(7), 2034–2054. Scholar
  44. Chimen, M., Kennedy, A., Nirantharakumar, K., Pang, T. T., Andrews, R., & Narendran, P. (2012). What are the health benefits of physical activity in type 1 diabetes mellitus? A literature review. Diabetologia, 55(3), 542–551. Scholar
  45. Cho, Y. H., Craig, M. E., & Donaghue, K. C. (2014). Puberty as an accelerator for diabetes complications. Pediatric Diabetes, 15(1), 18–26. Scholar
  46. Colberg, S. R., Sigal, R. J., Fernhall, B., Regensteiner, J. G., Blissmer, B. J., Rubin, R. R., & American Diabetes, A. (2010). Exercise and type 2 diabetes: The American College of Sports Medicine and the American Diabetes Association: Joint position statement executive summary. Diabetes Care, 33(12), 2692–2696. Scholar
  47. Conway, B. N., Han, X., Munro, H. M., Gross, A. L., Shu, X. O., Hargreaves, M. K., & Blot, W. J. (2018). The obesity epidemic and rising diabetes incidence in a low-income racially diverse southern US cohort. PLoS ONE, 13(1), e0190993. Scholar
  48. Coulon, S. J., Velasco-Gonzalez, C., Scribner, R., Park, C. L., Gomez, R., Vargas, A., & Hempe, J. M. (2017). Racial differences in neighborhood disadvantage, inflammation and metabolic control in black and white pediatric type 1 diabetes patients. Pediatric Diabetes, 18(2), 120–127. Scholar
  49. Cryer, P. E. (1999). Symptoms of hypoglycemia, thresholds for their occurrence, and hypoglycemia unawareness. Endocrinology and Metabolism Clinics of North America, 28(3), 495–500. v-vi.PubMedCrossRefGoogle Scholar
  50. Cryer, P. E. (2004). Diverse causes of hypoglycemia-associated autonomic failure in diabetes. The New England Journal of Medicine, 350(22), 2272–2279. Scholar
  51. D’Adamo, E., & Caprio, S. (2011). Type 2 diabetes in youth: Epidemiology and pathophysiology. Diabetes Care, 34(Suppl 2), S161–S165. Scholar
  52. Dabelea, D., Dolan, L. M., D’Agostino, R., Jr., Hernandez, A. M., McAteer, J. B., Hamman, R. F., & Florez, J. C. (2011). Association testing of TCF7L2 polymorphisms with type 2 diabetes in multi-ethnic youth. Diabetologia, 54(3), 535–539. Scholar
  53. Dabelea, D., Hanson, R. L., Bennett, P. H., Roumain, J., Knowler, W. C., & Pettitt, D. J. (1998). Increasing prevalence of type II diabetes in American Indian children. Diabetologia, 41(8), 904–910. Scholar
  54. Dabelea, D., Mayer-Davis, E. J., Saydah, S., Imperatore, G., Linder, B., Divers, J., & Study, S. f. D. i. Y. (2014). Prevalence of type 1 and type 2 diabetes among children and adolescents from 2001 to 2009. JAMA, 311(17), 1778–1786. Scholar
  55. Dabelea, D., Stafford, J. M., Mayer-Davis, E. J., D’Agostino, R., Jr., Dolan, L., Imperatore, G., & Group, S. f. D. i. Y. R. (2017). Association of type 1 diabetes vs type 2 diabetes diagnosed during childhood and adolescence with complications during teenage years and young adulthood. JAMA, 317(8), 825–835. Scholar
  56. Dahlquist, G., Stattin, E. L., & Rudberg, S. (2001). Urinary albumin excretion rate in the prediction of diabetic nephropathy;a long-term follow-up study of childhood onset type −1 diabetic patients. Nephrology, Dialysis, Transplantation, 16, 1382–1386.PubMedCrossRefGoogle Scholar
  57. Dai, W., Ye, L., Liu, A., Wen, S. W., Deng, J., Wu, X., & Lai, Z. (2017). Prevalence of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus: A meta-analysis. Medicine (Baltimore), 96(39), e8179. Scholar
  58. Dalla Pozza, R., Bechtold, S., Bonfig, W., Putzker, S., Kozlik-Feldmann, R., Schwarz, H. P., & Netz, H. (2007). Impaired short-term blood pressure regulation and autonomic dysbalance in children with type 1 diabetes mellitus. Diabetologia, 50(12), 2417–2423. Scholar
  59. Danese, A., & McEwen, B. S. (2012). Adverse childhood experiences, allostasis, allostatic load, and age-related disease. Physiology & Behavior, 106(1), 29–39. Scholar
  60. Dart, A. B., Sellers, E. A., & Dean, H. J. (2012). Kidney disease and youth onset type 2 diabetes: considerations for the general practitioner. International Journal Of Pediatrics, 2012, 237360. Scholar
  61. Davis, E. A., & Jones, T. W. (1998). Hypoglycemia in children with diabetes: Incidence, counterregulation and cognitive dysfunction. Journal of Pediatric Endocrinology & Metabolism, 11(Suppl 1), 177–182.Google Scholar
  62. Dayal, D., Samprathi, M., Jayaraman, D., Kohat, D., & Bhalla, A. K. (2016). Secular trends of body mass index in North Indian children with Type 1 diabetes do not support the accelerator hypothesis. Clinical Endocrinology, 84(3), 338–341. Scholar
  63. Dean, H. J., & Sellers, E. A. (2007). Comorbidities and microvascular complications of type 2 diabetes in children and adolescents. Pediatric Diabetes, 8(Suppl 9), 35–41. Scholar
  64. Defronzo, R. A. (2009). Banting lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes, 58(4), 773–795. Scholar
  65. Delva, J., O’Malley, P. M., & Johnston, L. D. (2006). Racial/ethnic and socioeconomic status differences in overweight and health-related behaviors among American students: National trends 1986–2003. The Journal of Adolescent Health, 39(4), 536–545. Scholar
  66. Diabetes Control and Complications Trial Research Group, Nathan, D. M., Genuth, S., Lachin, J., Cleary, P., & Siebert, C. (1993). The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The New England Journal of Medicine, 329(14), 977–986.
  67. Diez Roux, A. V. (2003). Residential environments and cardiovascular risk. Journal of Urban Health, 80(4), 569–589. Scholar
  68. Diez Roux, A. V., & Mair, C. (2010). Neighborhoods and health. Annals of the New York Academy of Sciences, 1186, 125–145. Scholar
  69. Ding, D., Sallis, J. F., Kerr, J., Lee, S., & Rosenberg, D. E. (2011). Neighborhood environment and physical activity among youth a review. American Journal of Preventive Medicine, 41(4), 442–455. Scholar
  70. Doamekpor, L. A., & Dinwiddie, G. Y. (2015). Allostatic load in foreign-born and US-born blacks: evidence from the 2001 to 2010 National Health and Nutrition Examination Survey. American Journal of Public Health, 105(3), 591–597. Scholar
  71. Dunger, D. B., Sperling, M. A., Acerini, C. L., Bohn, D. J., Daneman, D., Danne, T. P., & Lwpes. (2004). ESPE/LWPES consensus statement on diabetic ketoacidosis in children and adolescents. Archives of Disease in Childhood, 89(2), 188–194.PubMedPubMedCentralCrossRefGoogle Scholar
  72. Eppens, M. C., Craig, M. E., Cusumano, J., Hing, S., Chan, A. K., Howard, N. J., & Donaghue, K. C. (2006). Prevalence of diabetes complications in adolescents with type 2 compared with type 1 diabetes. Diabetes Care, 29(6), 1300–1306. Scholar
  73. Fall, C. H. (2011). Evidence for the intra-uterine programming of adiposity in later life. Annals of Human Biology, 38(4), 410–428. Scholar
  74. Fall, C. H. (2013). Fetal programming and the risk of noncommunicable disease. Indian Journal of Pediatrics, 80(Suppl 1), S13–S20. Scholar
  75. Farag, Y. M., & Gaballa, M. R. (2011). Diabesity: An overview of a rising epidemic. Nephrology, Dialysis, Transplantation, 26(1), 28–35. Scholar
  76. Felipe, D. L., Hempe, J. M., Liu, S., Matter, N., Maynard, J., Linares, C., & Chalew, S. A. (2011). Skin intrinsic fluorescence is associated with hemoglobin A(1c )and hemoglobin glycation index but not mean blood glucose in children with type 1 diabetes. Diabetes Care, 34(8), 1816–1820. Scholar
  77. Fiscella, K., & Sanders, M. R. (2016). Racial and ethnic disparities in the quality of health care. Annual Review of Public Health, 37, 375–394. Scholar
  78. Foster, S., & Giles-Corti, B. (2008). The built environment, neighborhood crime and constrained physical activity: An exploration of inconsistent findings. Preventive Medicine, 47(3), 241–251. S0091-7435(08)00158-8 [pii].CrossRefPubMedGoogle Scholar
  79. Fourlanos, S., Harrison, L. C., & Colman, P. G. (2008). The accelerator hypothesis and increasing incidence of type 1 diabetes. Current Opinion in Endocrinology, Diabetes, and Obesity, 15(4), 321–325. Scholar
  80. Franco, M., Diez Roux, A. V., Glass, T. A., Caballero, B., & Brancati, F. L. (2008). Neighborhood characteristics and availability of healthy foods in Baltimore. American Journal of Preventive Medicine, 35(6), 561–567. Scholar
  81. Frech, A., & Kimbro, R. T. (2011). Maternal mental health, neighborhood characteristics, and time investments in children. Journal of Marriage and Family, 73(3), 605–620. Scholar
  82. Genuth, S., Sun, W., Cleary, P., Gao, X., Sell, D. R., Lachin, J., & Monnier, V. M. (2015). Skin advanced glycation end products glucosepane and methylglyoxal hydroimidazolone are independently associated with long-term microvascular complication progression of type 1 diabetes. Diabetes, 64(1), 266–278. Scholar
  83. Geronimus, A. T., Hicken, M., Keene, D., & Bound, J. (2006). “Weathering” and age patterns of allostatic load scores among blacks and whites in the United States. American Journal of Public Health, 96(5), 826–833. Scholar
  84. Goh, S. Y., & Cooper, M. E. (2008). Clinical review: The role of advanced glycation end products in progression and complications of diabetes. The Journal of Clinical Endocrinology and Metabolism, 93(4), 1143–1152. Scholar
  85. Golden, S. H., Brown, A., Cauley, J. A., Chin, M. H., Gary-Webb, T. L., Kim, C., & Anton, B. (2012). Health disparities in endocrine disorders: Biological, clinical, and nonclinical factors – an endocrine society scientific statement. The Journal of Clinical Endocrinology and Metabolism, 97(9), E1579–E1639. Scholar
  86. Gonzalez, J. S., Peyrot, M., McCarl, L. A., Collins, E. M., Serpa, L., Mimiaga, M. J., & Safren, S. A. (2008). Depression and diabetes treatment nonadherence: A meta-analysis. Diabetes Care, 31(12), 2398–2403. Scholar
  87. Goran, M. I., Bergman, R. N., Cruz, M. L., & Watanabe, R. (2002). Insulin resistance and associated compensatory responses in african-american and Hispanic children. Diabetes Care, 25(12), 2184–2190.PubMedCrossRefGoogle Scholar
  88. Gotzsche, O., Darwish, A., Gotzsche, L., Hansen, L. P., & Sorensen, K. E. (1996). Incipient cardiomyopathy in young insulin-dependent diabetic patients: A seven-year prospective Doppler echocardiographic study. Diabetic Medicine, 13(9), 834–840.<834::AID-DIA225>3.0.CO;2-MCrossRefPubMedGoogle Scholar
  89. Group, S. f. D. i. Y. S, Liese, A. D., D’Agostino, R. B., Jr., Hamman, R. F., Kilgo, P. D., Lawrence, J. M., & Williams, D. E. (2006). The burden of diabetes mellitus among US youth: Prevalence estimates from the SEARCH for diabetes in youth study. Pediatrics, 118(4), 1510–1518. Scholar
  90. Group, S. S. (2004). SEARCH for diabetes in youth: A multicenter study of the prevalence, incidence and classification of diabetes mellitus in youth. Controlled Clinical Trials, 25(5), 458–471. Scholar
  91. Group, U. K. H. S. (2007). Risk of hypoglycaemia in types 1 and 2 diabetes: Effects of treatment modalities and their duration. Diabetologia, 50(6), 1140–1147. Scholar
  92. Gubitosi-Klug, R. A., & DCCT/EDIC Research Group (2014). The diabetes control and complications trial/epidemiology of diabetes interventions and complications study at 30 years: Summary and future directions. Diabetes Care, 37(1), 44–49. Scholar
  93. Gungor, N., & Arslanian, S. (2004). Progressive beta cell failure in type 2 diabetes mellitus of youth. The Journal of Pediatrics, 144(5), 656–659. Scholar
  94. Gungor, N., Hannon, T., Libman, I., Bacha, F., & Arslanian, S. (2005). Type 2 diabetes mellitus in youth: The complete picture to date. Pediatric Clinics of North America, 52(6), 1579–1609. Scholar
  95. Guntsche, Z., Saravi, F. D., Reynals, E. A., Rauek, B., Rauek, M., & Guntsche, E. M. (2002). Parental hypertension and 24 h-blood pressure in children prior to diabetic nephropathy. Pediatric Nephrology, 17(3), 157–164. Scholar
  96. Hajjar, I., & Kotchen, T. A. (2003). Trends in prevalence, awareness, treatment, and control of hypertension in the United States, 1988–2000. JAMA, 290(2), 199–206. Scholar
  97. Hamdan, M. A., & Chalew, S. A. (2017). Does iron status explain racial disparity in mean blood glucose independent HbA1c outcome for children with type 1 DM? Diabetes, 66(Supplement 1), A643.Google Scholar
  98. Hamdan, M. A., Hempe, J. M., Velasco-Gonzalez, C., Gomez, R., Vargas, A., & Chalew, S. (2016). Differences in red blood cell indices do not explain racial disparity in hemoglobin A1c in children with type 1 diabetes. The Journal of Pediatrics, 176, 197–199. Scholar
  99. Hamman, R. F., Bell, R. A., Dabelea, D., D’Agostino, R. B., Jr., Dolan, L., Imperatore, G., & Group, S. f. D. i. Y. S. (2014). The SEARCH for diabetes in youth study: Rationale, findings, and future directions. Diabetes Care, 37(12), 3336–3344. Scholar
  100. Harrington, J., Pena, A. S., Gent, R., Hirte, C., & Couper, J. (2010). Aortic intima media thickness is an early marker of atherosclerosis in children with type 1 diabetes mellitus. The Journal of Pediatrics, 156(2), 237–241. Scholar
  101. Harvey, J. N., Rizvi, K., Craney, L., Messenger, J., Shah, R., & Meadows, P. A. (2001). Population-based survey and analysis of trends in the prevalence of diabetic nephropathy in Type 1 diabetes. Diabetic Medicine, 18(12), 998–1002.PubMedCrossRefGoogle Scholar
  102. Heisler, M., Bouknight, R. R., Hayward, R. A., Smith, D. M., & Kerr, E. A. (2002). The relative importance of physician communication, participatory decision making, and patient understanding in diabetes self-management. Journal of General Internal Medicine, 17(4), 243–252.PubMedPubMedCentralCrossRefGoogle Scholar
  103. Hempe, J. M., Liu, S., Myers, L., McCarter, R. J., Buse, J. B., & Fonseca, V. (2015). The hemoglobin glycation index identifies subpopulations with harms or benefits from intensive treatment in the ACCORD trial. Diabetes Care, 38(6), 1067–1074. Scholar
  104. Hensel, K. O., Grimmer, F., Roskopf, M., Jenke, A. C., Wirth, S., & Heusch, A. (2016). Subclinical alterations of cardiac mechanics present early in the course of pediatric type 1 diabetes nellitus: A prospective blinded speckle tracking stress echocardiography study. Journal Diabetes Research, 2016, 2583747. Scholar
  105. Herman, W. H., & Cohen, R. M. (2012). Racial and ethnic differences in the relationship between HbA1c and blood glucose: Implications for the diagnosis of diabetes. The Journal of Clinical Endocrinology and Metabolism, 97(4), 1067–1072. Scholar
  106. Hovind, P., Tarnow, L., Rossing, K., Rossing, P., Eising, S., Larsen, N., & Parving, H. H. (2003). Decreasing incidence of severe diabetic microangiopathy in type 1 diabetes. Diabetes Care, 26(4), 1258–1264.PubMedCrossRefGoogle Scholar
  107. Hudson, O. D., Nunez, M., & Shaibi, G.Q. (2012). Ethnicity and elevated liver transaminases among newly diagnosed children with type 2 diabetes. BMC Pediatrics, 12(174).
  108. Hyllienmark, L., Brismar, T., & Ludvigsson, J. (1995). Subclinical nerve dysfunction in children and adolescents with IDDM. Diabetologia, 38(6), 685–692.PubMedCrossRefGoogle Scholar
  109. Hypoglycemia in the Diabetes Control and Complications Trial. (1997). The diabetes control and complications trial research group. Diabetes, 46(2), 271–286.CrossRefGoogle Scholar
  110. Imperatore, G., Boyle, J. P., Thompson, T. J., Case, D., Dabelea, D., Hamman, R. F., & Group, S. f. D. i. Y. S. (2012). Projections of type 1 and type 2 diabetes burden in the U.S. population aged <20 years through 2050: Dynamic modeling of incidence, mortality, and population growth. Diabetes Care, 35(12), 2515–2520. Scholar
  111. Implications of the United Kingdom Prospective Diabetes Study. American Diabetes Association. (1998). Diabetes Care, 21(12), 2180–2184.CrossRefGoogle Scholar
  112. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. (1998). Lancet, 352(9131), 837–853.CrossRefGoogle Scholar
  113. Islam, S. T., Srinivasan, S., & Craig, M. E. (2014). Environmental determinants of type 1 diabetes: a role for overweight and insulin resistance. Journal of Paediatrics and Child Health, 50(11), 874–879. Scholar
  114. ISPAD Clinical Practice Consensus Guidelines (2018). DiMeglio L, Acerini C, Codner E, Craig M, Hofer S, Pillay K, Maahs D. Pediatric Diabetes online. Scholar
  115. Jaiswal, M., Lauer, A., Martin, C. L., Bell, R. A., Divers, J., Dabelea, D., & Group, S. f. D. i. Y. S. (2013). Peripheral neuropathy in adolescents and young adults with type 1 and type 2 diabetes from the SEARCH for diabetes in youth follow-up cohort: A pilot study. Diabetes Care, 36(12), 3903–3908. Scholar
  116. Kamps, J. L., Hempe, J. M., & Chalew, S. A. (2010). Racial disparity in A1C independent of mean blood glucose in children with type 1 diabetes. Diabetes Care, 33(5), 1025–1027. Scholar
  117. Karavanaki, K., & Baum, J. D. (2003). Coexistence of impaired indices of autonomic neuropathy and diabetic nephropathy in a cohort of children with type 1 diabetes mellitus. Journal of Pediatric Endocrinology & Metabolism, 16(1), 79–90.CrossRefGoogle Scholar
  118. Karter, A. J., Ferrara, A., Liu, J. Y., Moffet, H. H., Ackerson, L. M., & Selby, J. V. (2002). Ethnic disparities in diabetic complications in an insured population. JAMA, 287(19), 2519–2527.PubMedCrossRefGoogle Scholar
  119. Katzmarzyk, P. T., Denstel, K. D., Beals, K., Bolling, C., Wright, C., Crouter, S. E., & Sisson, S. B. (2016). Results from the United States of America’s 2016 report card on physical activity for children and youth. Journal of Physical Activity & Health, 13(11 Suppl 2), S307–S313. Scholar
  120. Kaufman, F. R., & Shaw, J. (2007). Type 2 diabetes in youth: Rates, antecedents, treatment, problems and prevention. Pediatric Diabetes, 8(Suppl 9), 4–6. Scholar
  121. Kepper, M. M., Sothern, M. S., Theall, K. P., Griffiths, L. A., Scribner, R. A., Tseng, T. S., & Broyles, S. T. (2017). A reliable, feasible method to observe neighborhoods at high spatial resolution. American Journal of Preventive Medicine, 52(1S1), S20–S30. Scholar
  122. Kershnar, A. K., Daniels, S. R., Imperatore, G., Palla, S. L., Petitti, D. B., Pettitt, D. J., & Rodriguez, B. L. (2006). Lipid abnormalities are prevalent in youth with type 1 and type 2 diabetes: The SEARCH for diabetes in youth study. The Journal of Pediatrics, 149(3), 314–319. Scholar
  123. Kim, H., Elmi, A., Henderson, C. L., Cogen, F. R., & Kaplowitz, P. B. (2012). Characteristics of children with type 1 diabetes and persistent suboptimal glycemic control. Journal of Clinical Research in Pediatric Endocrinology, 4(2), 82–88. Scholar
  124. Kimbro, R. T., Brooks-Gunn, J., & McLanahan, S. (2011). Young children in urban areas: Links among neighborhood characteristics, weight status, outdoor play, and television watching. Social Science & Medicine, 72(5), 668–676. Scholar
  125. Kirk, J. K., D’Agostino, R. B., Jr., Bell, R. A., Passmore, L. V., Bonds, D. E., Karter, A. J., & Narayan, K. M. (2006). Disparities in HbA1c levels between African-American and non-Hispanic white adults with diabetes: A meta-analysis. Diabetes Care, 29(9), 2130–2136. Scholar
  126. Kirk, J. K., Passmore, L. V., Bell, R. A., Narayan, K. M., D’Agostino, R. B., Jr., Arcury, T. A., & Quandt, S. A. (2008). Disparities in A1C levels between Hispanic and non-Hispanic white adults with diabetes: A meta-analysis. Diabetes Care, 31(2), 240–246. Scholar
  127. Kotb, N. A., Gaber, R., Salama, M., Nagy, H. M., & Elhendy, A. (2012). Clinical and biochemical predictors of increased carotid intima-media thickness in overweight and obese adolescents with type 2 diabetes. Diabetes & Vascular Disease Research, 9(1), 35–41. Scholar
  128. Krakoff, J., Lindsay, R. S., Looker, H. C., Nelson, R. G., Hanson, R. L., & Knowler, W. C. (2003). Incidence of retinopathy and nephropathy in youth-onset compared with adult-onset type 2 diabetes. Diabetes Care, 26(1), 76–81.PubMedCrossRefGoogle Scholar
  129. Krause, M., Rudiger, H., Bald, M., Nake, A., & Paditz, E. (2009). Autonomic blood pressure control in children and adolescents with type 1 diabetes mellitus. Pediatric Diabetes, 10(4), 255–263. Scholar
  130. Krauss, R. M., Eckel, R. H., Howard, B., Appel, L. J., Daniels, S. R., Deckelbaum, R. J., & Bazzarre, T. L. (2000). AHA Dietary Guidelines: Revision 2000: A statement for healthcare professionals from the Nutrition Committee of the American Heart Association. Circulation, 102(18), 2284–2299.PubMedCrossRefGoogle Scholar
  131. Lado, J. J., & Lipman, T. H. (2016). Racial and ethnic disparities in the incidence, treatment, and outcomes of youth with type 1 diabetes. Endocrinology and Metabolism Clinics of North America, 45(2), 453–461. Scholar
  132. Lampard, A. M., Jurkowski, J. M., Lawson, H. A., & Davison, K. K. (2013). Family ecological predictors of physical activity parenting in low-income families. Behavioral Medicine, 39(4), 97–103. Scholar
  133. Larson, N. I., Story, M. T., & Nelson, M. C. (2009). Neighborhood environments: Disparities in access to healthy foods in the US. The American Journal of Preventive Medicine, 36(1), 74–81. Scholar
  134. Lawrence, J. M., Imperatore, G., Dabelea, D., Mayer-Davis, E. J., Linder, B., Saydah, S., & Group, S. f. D. i. Y. S. (2014). Trends in incidence of type 1 diabetes among non-Hispanic white youth in the U.S., 2002–2009. Diabetes, 63(11), 3938–3945. Scholar
  135. Lawrence, J. M., Mayer-Davis, E. J., Reynolds, K., Beyer, J., Pettitt, D. J., D’Agostino, R. B., Jr., Group, S. f. D. i. Y. S. (2009). Diabetes in Hispanic American youth: Prevalence, incidence, demographics, and clinical characteristics: The SEARCH for Diabetes in Youth Study. Diabetes Care, 32(Suppl 2), S123–132. doi: Scholar
  136. Leite, N. C., Salles, G. F., Araujo, A. L., Villela-Nogueira, C. A., & Cardoso, C. R. (2009). Prevalence and associated factors of non-alcoholic fatty liver disease in patients with type-2 diabetes mellitus. Liver International, 29(1), 113–119. Scholar
  137. Lilje, C., Cronan, J. C., Schwartzenburg, E. J., Owers, E. M., Clesi, P., Gomez, R., & Cardinale, J. P. (2017). Intima-media thickness at different arterial segments in pediatric type 1 diabetes patients and its relationship with advanced glycation end products. Pediatric Diabetes. Scholar
  138. Lindback, S. M., Gabbert, C., Johnson, B. L., Smorodinsky, E., Sirlin, C. B., Garcia, N., & Schwimmer, J. B. (2010). Pediatric nonalcoholic fatty liver disease: A comprehensive review. Adv Pediatr, 57(1), 85–140. Scholar
  139. Lipman, T. H., Levitt Katz, L. E., Ratcliffe, S. J., Murphy, K. M., Aguilar, A., Rezvani, I., & Suarez, E. (2013). Increasing incidence of type 1 diabetes in youth: Twenty years of the Philadelphia Pediatric Diabetes Registry. Diabetes Care, 36(6), 1597–1603. Scholar
  140. Lipton, R., Good, G., Mikhailov, T., Freels, S., & Donoghue, E. (1999). Ethnic differences in mortality from insulin-dependent diabetes mellitus among people less than 25 years of age. Pediatrics, 103(5 Pt 1), 952–956.PubMedCrossRefPubMedCentralGoogle Scholar
  141. Liu, L. L., Lawrence, J. M., Davis, C., Liese, A. D., Pettitt, D. J., Pihoker, C., & Group, S. f. D. i. Y. S. (2010). Prevalence of overweight and obesity in youth with diabetes in USA: The SEARCH for Diabetes in Youth study. Pediatric Diabetes, 11(1), 4–11. Scholar
  142. Lomonaco, R., Chen, J., & Cusi, K. (2011). An endocrine perspective of Nonalcoholic Fatty Liver Disease (NAFLD). Therapeutic Advances in Endocrinology and Metabolism, 2(5), 211–225. Scholar
  143. Loomba, R., Sirlin, C. B., Schwimmer, J. B., & Lavine, J. E. (2009). Advances in pediatric nonalcoholic fatty liver disease. Hepatology, 50(4), 1282–1293. Scholar
  144. Lyssenko, V., Jonsson, A., Almgren, P., Pulizzi, N., Isomaa, B., Tuomi, T., & Groop, L. (2008). Clinical risk factors, DNA variants, and the development of type 2 diabetes. The New England Journal of Medicine, 359(21), 2220–2232. Scholar
  145. Maahs, D. M., Daniels, S. R., de Ferranti, S. D., Dichek, H. L., Flynn, J., Goldstein, B. I., & Cardiometabolic, H. (2014). Cardiovascular disease risk factors in youth with diabetes mellitus: A scientific statement from the American Heart Association. Circulation, 130(17), 1532–1558. Scholar
  146. Maahs, D. M., Snively, B. M., Bell, R. A., Dolan, L., Hirsch, I., Imperatore, G., & Dabelea, D. (2007). Higher prevalence of elevated albumin excretion in youth with type 2 than type 1 diabetes: The SEARCH for Diabetes in Youth study. Diabetes Care, 30(10), 2593–2598. Scholar
  147. Marshall, M. C., Jr. (2005). Diabetes in African Americans. Postgraduate Medical Journal, 81(962), 734–740. Scholar
  148. Mattei, J., Demissie, S., Falcon, L. M., Ordovas, J. M., & Tucker, K. (2010). Allostatic load is associated with chronic conditions in the Boston Puerto Rican Health Study. Social Science & Medicine, 70(12), 1988–1996. Scholar
  149. Mayer-Davis, E. J., Beyer, J., Bell, R. A., Dabelea, D., D’Agostino, R., Jr., Imperatore, G., & Group, S. f. D. i. Y. S. (2009). Diabetes in African American youth: Prevalence, incidence, and clinical characteristics: The SEARCH for Diabetes in Youth Study. Diabetes Care, 32(Suppl 2), S112–S122. Scholar
  150. Mayer-Davis, E. J., Lawrence, J. M., Dabelea, D., Divers, J., Isom, S., Dolan, L., & Study, S. f. D. i. Y. (2017). Incidence trends of type 1 and type 2 diabetes among youths, 2002–2012. The New England Journal of Medicine, 376(15), 1419–1429. Scholar
  151. McEwen, B. S. (1998). Stress, adaptation, and disease. Allostasis and allostatic load. Annals of the New York Academy of Sciences, 840, 33–44.PubMedCrossRefGoogle Scholar
  152. McEwen, B. S. (2000). Allostasis and allostatic load: Implications for neuropsychopharmacology. Neuropsychopharmacology, 22(2), 108–124. Scholar
  153. McEwen, B. S. (2004). Protection and damage from acute and chronic stress: Allostasis and allostatic overload and relevance to the pathophysiology of psychiatric disorders. Annals of the New York Academy of Sciences, 1032, 1–7. Scholar
  154. McGill, D. E., & Levitsky, L. L. (2016). Management of hypoglycemia in children and adolescents with type 1 diabetes mellitus. Current Diabetes Reports, 16(9), 88. Scholar
  155. Michaliszyn, S. F., & Faulkner, M. S. (2010). Physical activity and sedentary behavior in adolescents with type 1 diabetes. Research in Nursing & Health, 33(5), 441–449. Scholar
  156. Miller, G. E., Chen, E., & Parker, K. J. (2011). Psychological stress in childhood and susceptibility to the chronic diseases of aging: Moving toward a model of behavioral and biological mechanisms. Psychological Bulletin, 137(6), 959–997. Scholar
  157. Miller, K. M., Foster, N. C., Beck, R. W., Bergenstal, R. M., DuBose, S. N., DiMeglio, L. A., & Network, T. D. E. C. (2015). Current state of type 1 diabetes treatment in the U.S.: Updated data from the T1D Exchange clinic registry. Diabetes Care, 38(6), 971–978. Scholar
  158. Miller, R. G., Mahajan, H. D., Costacou, T., Sekikawa, A., Anderson, S. G., & Orchard, T. J. (2016). A contemporary estimate of total mortality and cardiovascular disease risk in young adults with type 1 diabetes: The Pittsburg epidemiologyof diabetes complications study. Diabetes Care, 39(12), 2296–2303.PubMedPubMedCentralCrossRefGoogle Scholar
  159. Mohanty, S. R., Troy, T. N., Huo, D., O’Brien, B. L., Jensen, D. M., & Hart, J. (2009). Influence of ethnicity on histological differences in non-alcoholic fatty liver disease. Journal of Hepatology, 50(4), 797–804. Scholar
  160. Moran, A., Jacobs, D. R., Jr., Steinberger, J., Hong, C. P., Prineas, R., Luepker, R., & Sinaiko, A. R. (1999). Insulin resistance during puberty: Results from clamp studies in 357 children. Diabetes, 48(10), 2039–2044.PubMedCrossRefPubMedCentralGoogle Scholar
  161. Mortensen, H. B., Marinelli, K., Norgaard, K., Main, K., Kastrup, K. W., Ibsen, K. K., & Parving, H. H. (1990). A nation-wide cross-sectional study of urinary albumin excretion rate, arterial blood pressure and blood glucose control in Danish children with type 1 diabetes mellitus. Danish Study Group of Diabetes in Childhood. Diabetic Medicine, 7(10), 887–897.PubMedCrossRefGoogle Scholar
  162. Moser, J. T., Langdon, D. R., Finkel, R. S., Ratcliffe, S. J., Foley, L. R., Andrews-Rearson, M. L., & Lipman, T. H. (2013). The evaluation of peripheral neuropathy in youth with type 1 diabetes. Diabetes Research and Clinical Practice, 100(1), e3–e6. Scholar
  163. Muntner, P., He, J., Cutler, J. A., Wildman, R. P., & Whelton, P. K. (2004). Trends in blood pressure among children and adolescents. JAMA, 291(17), 2107–2113. Scholar
  164. Musso, G., Gambino, R., Cassader, M., & Pagano, G. (2011). Meta-analysis: Natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity. Annals of Medicine, 43(8), 617–649. Scholar
  165. Nadeau, K. J., Klingensmith, G., & Zeitler, P. (2005). Type 2 diabetes in children is frequently associated with elevated alanine aminotransferase. Journal of Pediatric Gastroenterology and Nutrition, 41(1), 94–98.PubMedCrossRefPubMedCentralGoogle Scholar
  166. Narasimhan, S., & Weinstock, R. S. (2014). Youth-onset type 2 diabetes mellitus: Lessons learned from the TODAY study. Mayo Clinic Proceedings, 89(6), 806–816. Scholar
  167. Nathan, D. M., & Group D. E. R. (2014). The diabetes control and complications trial/epidemiology of diabetes interventions and complications study at 30 years: Overview. Diabetes Care, 37(1), 9–16. Scholar
  168. National High Blood Pressure Education Program Working Group on High Blood Pressure in, C., & Adolescents. (2004). The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics, 114(2 Suppl 4th Report), 555–576.Google Scholar
  169. Neufeld, N. D., Raffel, L. J., Landon, C., Chen, Y. D., & Vadheim, C. M. (1998). Early presentation of type 2 diabetes in Mexican-American youth. Diabetes Care, 21(1), 80–86.PubMedCrossRefPubMedCentralGoogle Scholar
  170. Newfield, R. S., Dewan, A. K., & Jain, S. (2008). Dyslipidemia in children with type 2 diabetes vs. obesity. Pediatric Diabetes, 9(2), 115–121. Scholar
  171. Newton, K. P., Hou, J., Crimmins, N. A., Lavine, J. E., Barlow, S. E., Xanthakos, S. A., & Nonalcoholic Steatohepatitis Clinical Research, N. (2016). Prevalence of prediabetes and type 2 diabetes in children with nonalcoholic fatty liver disease. JAMA Pediatrics, 170(10), e161971. Scholar
  172. Nishikawa, T., Edelstein, D., Du, X. L., Yamagishi, S., Matsumura, T., Kaneda, Y., & Brownlee, M. (2000). Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature, 404(6779), 787–790. Scholar
  173. Nobili, V., Alkhouri, N., Bartuli, A., Manco, M., Lopez, R., Alisi, A., & Feldstein, A. E. (2010). Severity of liver injury and atherogenic lipid profile in children with nonalcoholic fatty liver disease. Pediatric Research, 67(6), 665–670. Scholar
  174. Nordin, C. (2010). The case for hypoglycaemia as a proarrhythmic event: basic and clinical evidence. Diabetologia, 53(8), 1552–1561. Scholar
  175. Odgers, C. L., Caspi, A., Bates, C. J., Sampson, R. J., & Moffitt, T. E. (2012). Systematic social observation of children’s neighborhoods using Google Street View: A reliable and cost-effective method. Journal of Child Psychology and Psychiatry, 53(10), 1009–1017. Scholar
  176. Ogden, C. L., Carroll, M. D., Kit, B. K., & Flegal, K. M. (2014). Prevalence of childhood and adult obesity in the United States, 2011–2012. JAMA, 311(8), 806–814. Scholar
  177. Paris, C. A., Imperatore, G., Klingensmith, G., Petitti, D., Rodriguez, B., Anderson, A. M., & Pihoker, C. (2009). Predictors of insulin regimens and impact on outcomes in youth with type 1 diabetes: The SEARCH for diabetes in youth Study. The Journal of Pediatrics, 155(2), 183–189. e181. Scholar
  178. Patterson, C. C., Dahlquist, G., Harjutsalo, V., Joner, G., Feltbower, R. G., Svensson, J., & Soltesz, G. (2007). Early mortality in EURODIAB population-based cohorts of type 1 diabetes diagnosed in childhood since 1989. Diabetologia, 50(12), 2439–2442. Scholar
  179. Petitti, D. B., Imperatore, G., Palla, S. L., Daniels, S. R., Dolan, L. M., Kershnar, A. K., & Group, S. f. D. i. Y. S. (2007). Serum lipids and glucose control: The SEARCH for diabetes in youth study. Archives of Pediatrics & Adolescent Medicine, 161(2), 159–165. Scholar
  180. Petrie, D., Lung, T. W., Rawshani, A., Palmer, A. J., Svensson, A. M., Eliasson, B., & Clarke, P. (2016). Recent trends in life expectancy for people with type 1 diabetes in Sweden. Diabetologia, 59(6), 1167–1176. Scholar
  181. Pettitt, D. J., Talton, J., Dabelea, D., Divers, J., Imperatore, G., Lawrence, J. M., & Group, S. f. D. i. Y. S. (2014). Prevalence of diabetes in U.S. youth in 2009: The SEARCH for diabetes in youth study. Diabetes Care, 37(2), 402–408. Scholar
  182. Piette, J. D., Schillinger, D., Potter, M. B., & Heisler, M. (2003). Dimensions of patient-provider communication and diabetes self-care in an ethnically diverse population. Journal of General Internal Medicine, 18(8), 624–633.PubMedPubMedCentralCrossRefGoogle Scholar
  183. Pinhas-Hamiel, O., & Zeitler, P. (2000). “Who is the wise man? – The one who foresees consequences:”. Childhood obesity, new associated comorbidity and prevention. Preventive Medicine, 31(6), 702–705. Scholar
  184. Pinhas-Hamiel, O., & Zeitler, P. (2005). The global spread of type 2 diabetes mellitus in children and adolescents. The Journal of Pediatrics, 146(5), 693–700. Scholar
  185. Pinhas-Hamiel, O., & Zeitler, P. (2007). Acute and chronic complications of type 2 diabetes mellitus in children and adolescents. Lancet, 369(9575), 1823–1831. Scholar
  186. Prevention, C. f. D. C. a. Prevalence of abnormal lipid levels among youths – United States, 1999–2006. MMWR Morb Mortal Weekly Rep, 59(29–33), 2010.Google Scholar
  187. Prevention., C. f. D. C. a. National diabetes statistics report. 2014. Available at: SatisticsReport.html.
  188. Prevention., C. f. D. C. a. National Diabetes Statistics Report, 2017. Atlanta, GA, Centers for Disease Control and Prevention, U.S. Dept of Health and Human Services; 2017.Google Scholar
  189. Pulgaron, E. R., & Delamater, A. M. (2014). Obesity and type 2 diabetes in children: Epidemiology and treatment. Current Diabetes Reports, 14(8), 508. Scholar
  190. Pulgaron, E. R., Sanders, L. M., Patino-Fernandez, A. M., Wile, D., Sanchez, J., Rothman, R. L., & Delamater, A. M. (2014). Glycemic control in young children with diabetes: The role of parental health literacy. Patient Education and Counseling, 94(1), 67–70. Scholar
  191. Reinehr, T. (2013). Type 2 diabetes mellitus in children and adolescents. World Journal of Diabetes, 4(6), 270–281. Scholar
  192. Ringel, R. E., Chalew, S. A., Armour, K. A., McLaughlin, J., McCarter, R. J., Jr., & Kramer, W. E. (1993). Cardiovascular reflex abnormalities in children and adolescents with diabetes mellitus. Diabetes Care, 16(5), 734–741.PubMedCrossRefGoogle Scholar
  193. Roglic, G., Colhoun, H. M., Stevens, L. K., Lemkes, H. H., Manes, C., & Fuller, J. H. (1998). Parental history of hypertension and parental history of diabetes and microvascular complications in insulin-dependent diabetes mellitus: The EURODIAB IDDM Complications Study. Diabetic Medicine, 15(5), 418–426.<418::AID-DIA604>3.0.CO;2-PCrossRefPubMedGoogle Scholar
  194. Rosenbloom, A. L., Joe, J. R., Young, R. S., & Winter, W. E. (1999). Emerging epidemic of type 2 diabetes in youth. Diabetes Care, 22(2), 345–354.PubMedCrossRefGoogle Scholar
  195. Rosenbloom, A. L., Silverstein, J. H., Amemiya, S., Zeitler, P., & Klingensmith, G. J. (2009). Type 2 diabetes in children and adolescents. Pediatric Diabetes, 10(Suppl 12), 17–32. Scholar
  196. Roy, M. S. (2000). Diabetic retinopathy in African Americans with type 1 diabetes: The New Jersey 725: I. Methodology, population, frequency of retinopathy, and visual impairment. Archives of Ophthalmology, 118(1), 97–104.PubMedCrossRefGoogle Scholar
  197. Rudberg, S., Stattin, E. L., & Dahlquist, G. (1998). Familial and perinatal risk factors for micro – and macroalbuminuria in young IDDM patients. Diabetes, 47(7), 1121–1126.PubMedCrossRefGoogle Scholar
  198. Sampson, R. J., Raudenbush, S. W., & Earls, F. (1997). Neighborhoods and violent crime: A multilevel study of collective efficacy. Science, 277(5328), 918–924.PubMedCrossRefGoogle Scholar
  199. Saydah, S., Imperatore, G., Cheng, Y., Geiss, L. S., & Albright, A. (2017). Disparities in diabetes deaths among children and adolescents – United States, 2000–2014. MMWR. Morbidity and Mortality Weekly Report, 66(19), 502–505. Scholar
  200. Schaefer-McDaniel, N., Caughy, M. O., O’Campo, P., & Gearey, W. (2010). Examining methodological details of neighbourhood observations and the relationship to health: A literature review. Social Science & Medicine, 70(2), 277–292. Scholar
  201. Schultz, C. J., Konopelska-Bahu, T., Dalton, R. N., Carroll, T. A., Stratton, I., Gale, E. A., & Dunger, D. B. (1999). Microalbuminuria prevalence varies with age, sex, and puberty in children with type 1 diabetes followed from diagnosis in a longitudinal study. Oxford Regional Prospective Study Group. Diabetes Care, 22(3), 495–502.PubMedCrossRefGoogle Scholar
  202. Schulz, A. J., Mentz, G., Lachance, L., Johnson, J., Gaines, C., & Israel, B. A. (2012). Associations between socioeconomic status and allostatic load: Effects of neighborhood poverty and tests of mediating pathways. American Journal of Public Health, 102(9), 1706–1714. Scholar
  203. Schwartz, D. D., Cline, V. D., Axelrad, M. E., & Anderson, B. J. (2011). Feasibility, acceptability, and predictive validity of a psychosocial screening program for children and youth newly diagnosed with type 1 diabetes. Diabetes Care, 34(2), 326–331. Scholar
  204. Schwimmer, J. B., Celedon, M. A., Lavine, J. E., Salem, R., Campbell, N., Schork, N. J., & Sirlin, C. B. (2009). Heritability of nonalcoholic fatty liver disease. Gastroenterology, 136(5), 1585–1592. Scholar
  205. Scott, C. R., Smith, J. M., Cradock, M. M., & Pihoker, C. (1997). Characteristics of youth-onset noninsulin-dependent diabetes mellitus and insulin-dependent diabetes mellitus at diagnosis. Pediatrics, 100(1), 84–91.PubMedCrossRefGoogle Scholar
  206. Seaquist, E. R., Miller, M. E., Bonds, D. E., Feinglos, M., Goff, D. C., Jr., Peterson, K., & Investigators, A. (2012). The impact of frequent and unrecognized hypoglycemia on mortality in the ACCORD study. Diabetes Care, 35(2), 409–414. Scholar
  207. Secrest, A. M., Becker, D. J., Kelsey, S. F., Laporte, R. E., & Orchard, T. J. (2010). Cause-specific mortality trends in a large population-based cohort with long-standing childhood-onset type 1 diabetes. Diabetes, 59(12), 3216–3222. Scholar
  208. Shafiee, G., Mohajeri-Tehrani, M., Pajouhi, M., & Larijani, B. (2012). The importance of hypoglycemia in diabetic patients. Journal of Diabetes and Metabolic Disorders, 11(1), 17. Scholar
  209. Shah, A. S., Dolan, L. M., Gao, Z., Kimball, T. R., & Urbina, E. M. (2012). Racial differences in arterial stiffness among adolescents and young adults with type 2 diabetes. Pediatric Diabetes, 13(2), 170–175. Scholar
  210. Shah, S., Baez, E. A., Felipe, D. L., Maynard, J. D., Hempe, J. M., & Chalew, S. A. (2013). Advanced glycation endproducts in children with diabetes. The Journal of Pediatrics, 163(5), 1427–1431.PubMedCrossRefGoogle Scholar
  211. Shaw, J. (2007). Epidemiology of childhood type 2 diabetes and obesity. Pediatric Diabetes, 8(Suppl 9), 7–15. Scholar
  212. Singh, G. K., Kogan, M. D., Siahpush, M., & van Dyck, P. C. (2008). Independent and joint effects of socioeconomic, behavioral, and neighborhood characteristics on physical inactivity and activity levels among US children and adolescents. Journal of Community Health, 33(4), 206–216. Scholar
  213. Singh, G. K., Siahpush, M., & Kogan, M. D. (2010). Rising social inequalities in US childhood obesity, 2003-2007. Annals of Epidemiology, 20(1), 40–52. Scholar
  214. Singh, R., Shaw, J., & Zimmet, P. (2004). Epidemiology of childhood type 2 diabetes in the developing world. Pediatric Diabetes, 5(3), 154–168. Scholar
  215. Skinner, A. C., & Skelton, J. A. (2014). Prevalence and trends in obesity and severe obesity among children in the United States, 1999–2012. JAMA Pediatrics, 168(6), 561–566. Scholar
  216. Smalls, B. L., Gregory, C. M., Zoller, J. S., & Egede, L. E. (2015). Direct and indirect effects of neighborhood factors and self-care on glycemic control in adults with type 2 diabetes. Journal of Diabetes and its Complications, 29(2), 186–191. Scholar
  217. Smalls, B. L., Gregory, C. M., Zoller, J. S., & Egede, L. E. (2016). Conceptualizing the effect of community and neighborhood factors on Type 2 diabetes health outcomes. Environment and Behavior, 2017;49(5), 560–582.Google Scholar
  218. Sochett, E., & Daneman, D. (1999). Early diabetes-related complications in children and adolescents with type 1 diabetes. Implications for screening and intervention. Endocrinology and Metabolism Clinics of North America, 28(4), 865–882.PubMedCrossRefGoogle Scholar
  219. Song, S. H. (2015). Complication characteristics between young-onset type 2 versus type 1 diabetes in a UK population. BMJ Open Diabetes Research & Care, 3(1), e000044. Scholar
  220. Spanakis, E. K., & Golden, S. H. (2013). Race/ethnic difference in diabetes and diabetic complications. Current Diabetes Reports, 13(6), 814–823. Scholar
  221. Specht, B. J., Wadwa, R. P., Snell-Bergeon, J. K., Nadeau, K. J., Bishop, F. K., & Maahs, D. M. (2013). Estimated insulin sensitivity and cardiovascular disease risk factors in adolescents with and without type 1 diabetes. The Journal of Pediatrics, 162(2), 297–301. Scholar
  222. Stanescu, D. E., Lord, K., & Lipman, T. H. (2012). The epidemiology of type 1 diabetes in children. Endocrinology and Metabolism Clinics of North America, 41(4), 679–694. Scholar
  223. Steptoe, A., Hackett, R. A., Lazzarino, A. I., Bostock, S., La Marca, R., Carvalho, L. A., & Hamer, M. (2014). Disruption of multisystem responses to stress in type 2 diabetes: Investigating the dynamics of allostatic load. Proceedings of the National Academy of Sciences of the United States of America, 111(44), 15693–15698. Scholar
  224. Stirban, A., Gawlowski, T., & Roden, M. (2014). Vascular effects of advanced glycation endproducts: Clinical effects and molecular mechanisms. Mol Metab, 3(2), 94–108. Scholar
  225. Sturm, R. (2002). The effects of obesity, smoking, and drinking on medical problems and costs. Health Aff (Millwood), 21(2), 245–253. Scholar
  226. Sultan, M. B., Starita, C., & Huang, K. (2012). Epidemiology, risk factors and management of paediatric diabetic retinopathy. The British Journal of Ophthalmology, 96(3), 312–317. Scholar
  227. Sumner, A. E. (2009). “Half the dsylipidemia of insulin resistance” is the dyslipidemia [corrected] of insulin-resistant Blacks. Ethnicity & Disease, 19(4), 462–465.Google Scholar
  228. Sumner, A. E., Vega, G. L., Genovese, D. J., Finley, K. B., Bergman, R. N., & Boston, R. C. (2005). Normal triglyceride levels despite insulin resistance in African Americans: Role of lipoprotein lipase. Metabolism, 54(7), 902–909. Scholar
  229. Sumner, A. E., Zhou, J., Doumatey, A., Imoisili, O. E., Amoah, A., Acheampong, J., & Rotimi, C. N. (2010). Low HDL-cholesterol with normal triglyceride levels is the most common lipid pattern in West Africans and African Americans with Metabolic Syndrome: Implications for cardiovascular disease prevention. CVD Prev Control, 5(3), 75–80. Scholar
  230. Taksali, S. E., Caprio, S., Dziura, J., Dufour, S., Cali, A. M., Goodman, T. R., & Weiss, R. (2008). High visceral and low abdominal subcutaneous fat stores in the obese adolescent: A determinant of an adverse metabolic phenotype. Diabetes, 57(2), 367–371. Scholar
  231. Tang, M., Chen, Y., & Krewski, D. (2003). Gender-related differences in the association between socioeconomic status and self-reported diabetes. International Journal of Epidemiology, 32(3), 381–385.PubMedCrossRefGoogle Scholar
  232. Targher, G., Bertolini, L., Chonchol, M., Rodella, S., Zoppini, G., Lippi, G., & Bonora, E. (2010). Non-alcoholic fatty liver disease is independently associated with an increased prevalence of chronic kidney disease and retinopathy in type 1 diabetic patients. Diabetologia, 53(7), 1341–1348. Scholar
  233. Targher, G., Bertolini, L., Rodella, S., Tessari, R., Zenari, L., Lippi, G., & Arcaro, G. (2007). Nonalcoholic fatty liver disease is independently associated with an increased incidence of cardiovascular events in type 2 diabetic patients. Diabetes Care, 30(8), 2119–2121. Scholar
  234. Targher, G., Bertolini, L., Rodella, S., Zoppini, G., Lippi, G., Day, C., & Muggeo, M. (2008). Non-alcoholic fatty liver disease is independently associated with an increased prevalence of chronic kidney disease and proliferative/laser-treated retinopathy in type 2 diabetic patients. Diabetologia, 51(3), 444–450. Scholar
  235. Tatsumi, Y., Morimoto, A., Miyamatsu, N., Noda, M., Ohno, Y., & Deura, K. (2015). Effect of body mass index on insulin secretion or sensitivity and diabetes. American Journal of Preventive Medicine, 48(2), 128–135. Scholar
  236. Theall, K., Drury, S., & Shirtcliff, E. (2012). Cumulative neighborhood risk of psychosocial stress and allostatic load in adolescents. American Journal of Epidemiology, 176(7), 164–174.CrossRefGoogle Scholar
  237. Todd, J., Armon, C., Griggs, A., Poole, S., & Berman, S. (2006). Increased rates of morbidity, mortality, and charges for hospitalized children with public or no health insurance as compared with children with private insurance in Colorado and the United States. Pediatrics, 118(2), 577–585. Scholar
  238. Torchinsky, M. Y., Gomez, R., Rao, J., Vargas, A., Mercante, D. E., & Chalew, S. A. (2004). Poor glycemic control is associated with increased diastolic blood pressure and heart rate in children with Type 1 diabetes. Journal of Diabetes and its Complications, 18(4), 220–223.PubMedCrossRefGoogle Scholar
  239. Trotta, D., Verrotti, A., Salladini, C., & Chiarelli, F. (2004). Diabetic neuropathy in children and adolescents. Pediatric Diabetes, 5(1), 44–57. Scholar
  240. Urbach, S. L., LaFranchi, S., Lambert, L., Lapidus, J. A., Daneman, D., & Becker, T. M. (2005). Predictors of glucose control in children and adolescents with type 1 diabetes mellitus. Pediatric Diabetes, 6(2), 69–74. Scholar
  241. Urbina, E. M., Kimball, T. R., McCoy, C. E., Khoury, P. R., Daniels, S. R., & Dolan, L. M. (2009). Youth with obesity and obesity-related type 2 diabetes mellitus demonstrate abnormalities in carotid structure and function. Circulation, 119(22), 2913–2919. Scholar
  242. Urbina, E. M., Wadwa, R. P., Davis, C., Snively, B. M., Dolan, L. M., Daniels, S. R., & Dabelea, D. (2010). Prevalence of increased arterial stiffness in children with type 1 diabetes mellitus differs by measurement site and sex: the SEARCH for Diabetes in Youth Study. The Journal of Pediatrics, 156(5), 731-737–737 e731. Scholar
  243. Usher-Smith, J. A., Thompson, M. J., Sharp, S. J., & Walter, F. M. (2011). Factors associated with the presence of diabetic ketoacidosis at diagnosis of diabetes in children and young adults: a systematic review. BMJ, 343, d4092. Scholar
  244. Uwaifo, G. I., Fallon, E. M., Chin, J., Elberg, J., Parikh, S. J., & Yanovski, J. A. (2002). Indices of insulin action, disposal, and secretion derived from fasting samples and clamps in normal glucose-tolerant black and white children. Diabetes Care, 25(11), 2081–2087.PubMedCrossRefGoogle Scholar
  245. Valenzuela, J. M., Seid, M., Waitzfelder, B., Anderson, A. M., Beavers, D. P., Dabelea, D. M., & Group, S. f. D. i. Y. S. (2014). Prevalence of and disparities in barriers to care experienced by youth with type 1 diabetes. The Journal of Pediatrics, 164(6), 1369–1375. e1361. Scholar
  246. Van Name, M., & Santoro, N. (2013). Type 2 diabetes mellitus in pediatrics: A new challenge. World Journal of Pediatrics, 9(4), 293–299. Scholar
  247. Vehik, K., Hamman, R. F., Lezotte, D., Norris, J. M., Klingensmith, G., Bloch, C., & Dabelea, D. (2007). Increasing incidence of type 1 diabetes in 0- to 17-year-old Colorado youth. Diabetes Care, 30(3), 503–509. Scholar
  248. Verrotti, A., Chiarelli, F., Blasetti, A., & Morgese, G. (1995). Autonomic neuropathy in diabetic children. Journal of Paediatrics and Child Health, 31(6), 545–548.PubMedCrossRefGoogle Scholar
  249. Verrotti, A., Loiacono, G., Mohn, A., & Chiarelli, F. (2009). New insights in diabetic autonomic neuropathy in children and adolescents. European Journal of Endocrinology, 161(6), 811–818. Scholar
  250. Volpe, M., Battistoni, A., Savoia, C., & Tocci, G. (2015). Understanding and treating hypertension in diabetic populations. Cardiovasc Diagn Ther, 5(5), 353–363. Scholar
  251. Wagner, J., Tsimikas, J., Abbott, G., de Groot, M., & Heapy, A. (2007). Racial and ethnic differences in diabetic patient-reported depression symptoms, diagnosis, and treatment. Diabetes Research and Clinical Practice, 75(1), 119–122. Scholar
  252. Waitzfelder, B., Pihoker, C., Klingensmith, G., Case, D., Anderson, A., Bell, R. A., & Group, S. f. D. i. Y. S. (2011). Adherence to guidelines for youths with diabetes mellitus. Pediatrics, 128(3), 531–538. Scholar
  253. Weiss, R., Bremer, A. A., & Lustig, R. H. (2013). What is metabolic syndrome, and why are children getting it? Annals of the New York Academy of Sciences, 1281, 123–140. Scholar
  254. Wilkin, T. J. (2009). The accelerator hypothesis: A review of the evidence for insulin resistance as the basis for type I as well as type II diabetes. International Journal of Obesity, 33(7), 716–726. Scholar
  255. Willi, S. M., Miller, K. M., DiMeglio, L. A., Klingensmith, G. J., Simmons, J. H., Tamborlane, W. V., & Network, T. D. E. C. (2015). Racial-ethnic disparities in management and outcomes among children with type 1 diabetes. Pediatrics, 135(3), 424–434. Scholar
  256. Williams, K. V., & Kelley, D. E. (2000). Metabolic consequences of weight loss on glucose metabolism and insulin action in type 2 diabetes. Diabetes, Obesity & Metabolism, 2(3), 121–129.CrossRefGoogle Scholar
  257. Wolfsdorf, J., Glaser, N., Sperling, M. A., & American Diabetes, A. (2006). Diabetic ketoacidosis in infants, children, and adolescents: A consensus statement from the American Diabetes Association. Diabetes Care, 29(5), 1150–1159. Scholar
  258. Wong, J., Constantino, M., & Yue, D. K. (2015). Morbidity and mortality in young-onset type 2 diabetes in comparison to type 1 diabetes: Where are we now? Current Diabetes Reports, 15(1), 566. Scholar
  259. Writing Group for the, S. f. D. i. Y. S. G, Dabelea, D., Bell, R. A., D’Agostino, R. B., Jr., Imperatore, G., Johansen, J. M., & Waitzfelder, B. (2007). Incidence of diabetes in youth in the United States. JAMA, 297(24), 2716–2724. Scholar
  260. Zeitler, P., Haqq, A., Rosenbloom, A., Glaser, N., & Drugs, & Therapeutics Committee of the Lawson Wilkins Pediatric Endocrine, S. (2011). Hyperglycemic hyperosmolar syndrome in children: Pathophysiological considerations and suggested guidelines for treatment. The Journal of Pediatrics, 158(1), 9-14–14 e11-12. Scholar
  261. Zerbini, G., Bonfanti, R., Meschi, F., Bognetti, E., Paesano, P. L., Gianolli, L., & Chiumello, G. (2006). Persistent renal hypertrophy and faster decline of glomerular filtrationrate precede the development of microalbuminuria in type 1 diabetes. Diabetes, 55, 2620–2625.PubMedCrossRefPubMedCentralGoogle Scholar
  262. Zuijdwijk, C. S., Cuerden, M., & Mahmud, F. H. (2013). Social determinants of health on glycemic control in pediatric type 1 diabetes. The Journal of Pediatrics, 162(4), 730–735. Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Carmen Mironovici
    • 1
    • 2
  • Maura Kepper
    • 3
  • Richard Scribner
    • 3
  • Stuart Chalew
    • 1
    • 2
    Email author
  1. 1.Division of Endocrinology/Diabetes, Department of Pediatrics, School of MedicineLouisiana State University Health Sciences CenterNew OrleansUSA
  2. 2.Division of EndocrinologyChildren’s Hospital of New OrleansNew OrleansUSA
  3. 3.School of Public HealthLouisiana State University Health Sciences CenterNew OrleansUSA

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