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U-Net with Spatial Pyramid Pooling for Drusen Segmentation in Optical Coherence Tomography

  • Rhona AsgariEmail author
  • Sebastian Waldstein
  • Ferdinand Schlanitz
  • Magdalena Baratsits
  • Ursula Schmidt-Erfurth
  • Hrvoje Bogunović
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 11855)

Abstract

The presence of drusen is the main hallmark of early/intermediate age-related macular degeneration (AMD). Therefore, automated drusen segmentation is an important step in image-guided management of AMD. There are two common approaches to drusen segmentation. In the first, the drusen are segmented directly as a binary classification task. In the second approach, the surrounding retinal layers (outer boundary retinal pigment epithelium (OBRPE) and Bruch’s membrane (BM)) are segmented and the remaining space between these two layers is extracted as drusen. In this work, we extend the standard U-Net architecture with spatial pyramid pooling components to introduce global feature context. We apply the model to the task of segmenting drusen together with BM and OBRPE. The proposed network was trained and evaluated on a longitudinal OCT dataset of 425 scans from 38 patients with early/intermediate AMD. This preliminary study showed that the proposed network consistently outperformed the standard U-net model.

Notes

Acknowledgment

This work was funded by the Christian Doppler Research Association, the Austrian Federal Ministry for Digital and Economic Affairs and the National Foundation for Research, Technology and Development. We thank the NVIDIA corporation for a GPU donation.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Rhona Asgari
    • 1
    Email author
  • Sebastian Waldstein
    • 1
  • Ferdinand Schlanitz
    • 1
  • Magdalena Baratsits
    • 1
  • Ursula Schmidt-Erfurth
    • 1
  • Hrvoje Bogunović
    • 1
  1. 1.Christian Doppler Laboratory for Ophthalmic Image Analysis, Department of OphthalmologyMedical University of ViennaViennaAustria

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