Multi-scale Deep Convolutional Neural Networks for Emphysema Classification and Quantification

  • Liying Peng
  • Lanfen LinEmail author
  • Hongjie Hu
  • Qiaowei Zhang
  • Huali Li
  • Qingqing Chen
  • Dan Wang
  • Xian-Hua Han
  • Yutaro Iwamoto
  • Yen-Wei Chen
  • Ruofeng Tong
  • Jian Wu
Part of the Intelligent Systems Reference Library book series (ISRL, volume 171)


In this work, we aim at classification and quantification of emphysema in computed tomography (CT) images of lungs. Most previous works are limited to extracting low-level features or mid-level features without enough high-level information. Moreover, these approaches do not take the characteristics (scales) of different emphysema into account, which are crucial for feature extraction. In contrast to previous works, we propose a novel deep learning method based on multi-scale deep convolutional neural networks. There are three contributions for this paper. First, we propose to use a base residual network with 20 layers to extract more high-level information. Second, we incorporate multi-scale information into our deep neural networks so as to take full consideration of the characteristics of different emphysema. A 92.68% classification accuracy is achieved on our original dataset. Finally, based on the classification results, we also perform the quantitative analysis of emphysema in 50 subjects by correlating the quantitative results (the area percentage of each class) with pulmonary functions. We show that centrilobular emphysema (CLE) and panlobular emphysema (PLE) have strong correlation with the pulmonary functions and the sum of CLE and PLE can be used as a new and accurate measure of emphysema severity instead of the conventional measure (sum of all subtypes of emphysema). The correlations between the new measure and various pulmonary functions are up to |r| \(= 0.922\) (r is correlation coefficient).



This work was supported in part by Zhejiang Lab Program under the Grant No.2018DG0ZX01, in part by the Key Science and Technology Innovation Support Program of Hangzhou under the Grant No.20172011A038, and in part by the Grant-in Aid for Scientific Research from the Japanese Ministry for Education, Science, Culture and Sports (MEXT) under the Grant No.18H03267 and No.17H00754.


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Liying Peng
    • 1
  • Lanfen Lin
    • 1
    Email author
  • Hongjie Hu
    • 2
  • Qiaowei Zhang
    • 2
  • Huali Li
    • 2
  • Qingqing Chen
    • 2
  • Dan Wang
    • 2
  • Xian-Hua Han
    • 3
  • Yutaro Iwamoto
    • 4
  • Yen-Wei Chen
    • 5
  • Ruofeng Tong
    • 1
  • Jian Wu
    • 1
  1. 1.College of Computer Science and Technology, Zhejiang UniversityHangzhouChina
  2. 2.Department of Radiology, Sir Run Run Shaw HospitalZhejiang UniversityHangzhouChina
  3. 3.Yamaguchi UniversityYamaguchiJapan
  4. 4.Graduate School of Information Science and EngineeringRitsumeikan UniversityKyotoJapan
  5. 5.Zhejiang LabHangzhou CityChina

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