Abstract
Brain Genome Association (BGA) study, which investigates the associations between brain structure/function (characterized by neuroimaging phenotypes) and genetic variations (characterized by Single Nucleotide Polymorphisms (SNPs)), is important in pathological analysis of neurological disease. However, the current BGA studies are limited as they did not explicitly consider the disease labels, source importance, and sample importance in their formulations. We address these issues by proposing a robust and discriminative BGA formulation. Specifically, we learn two transformation matrices for mapping two heterogeneous data sources (i.e., neuroimaging data and genetic data) into a common space, so that the samples from the same subject (but different sources) are close to each other, and also the samples with different labels are separable. In addition, we add a sparsity constraint on the transformation matrices to enable feature selection on both data sources. Furthermore, both sample importance and source importance are also considered in the formulation via adaptive parameter-free sample and source weightings. We have conducted various experiments, using Alzheimer’s Disease Neuroimaging Initiative (ADNI) dataset, to test how well the neuroimaging phenotypes and SNPs can represent each other in the common space.
This work was supported in part by NIH grants (AG053867, AG041721, and AG042599). X. Zhu was supported in part by the National Natural Science Foundation of China (61876046 and 61573270), the Guangxi High Institutions Program of Introducing 100 High-Level Overseas Talents, the Strategic Research Excellence Fund at Massey University, and the Marsden Fund of New Zealand (MAU1721). The authors thank the Alzheimer’s Disease Neuroimaging Initiative for providing the data sets.
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References
Brun, C.C., et al.: Mapping the regional influence of genetics on brain structure variability: a tensor-based morphometry study. NeuroImage 48(1), 37–49 (2009)
Du, L., et al.: A novel structure-aware sparse learning algorithm for brain imaging genetics. In: Golland, P., Hata, N., Barillot, C., Hornegger, J., Howe, R. (eds.) MICCAI 2014. LNCS, vol. 8675, pp. 329–336. Springer, Cham (2014). https://doi.org/10.1007/978-3-319-10443-0_42
Evgeniou, A., Pontil, M.: Multi-task feature learning. NIPS 19, 41–48 (2007)
Hao, X., Yu, J., Zhang, D.: Identifying genetic associations with MRI-derived measures via tree-guided sparse learning. In: Golland, P., Hata, N., Barillot, C., Hornegger, J., Howe, R. (eds.) MICCAI 2014. LNCS, vol. 8674, pp. 757–764. Springer, Cham (2014). https://doi.org/10.1007/978-3-319-10470-6_94
Lei, C., Zhu, X.: Unsupervised feature selection via local structure learning and sparse learning. Multimed. Tools Appl. 77(22), 29605–29622 (2018)
Lin, D., et al.: Sparse models for correlative and integrative analysis of imaging and genetic data. J. Neurosci. Methods 237, 69–78 (2014)
Stein, J.L., et al.: Voxelwise genome-wide association study (vGWAS). NeuroImage 53(3), 1160–1174 (2010)
Vounou, M., et al.: Discovering genetic associations with high-dimensional neuroimaging phenotypes: a sparse reduced-rank regression approach. NeuroImage 53(3), 1147–1159 (2010)
Vounou, M., et al.: Sparse reduced-rank regression detects genetic associations with voxel-wise longitudinal phenotypes in Alzheimer’s disease. NeuroImage 60(1), 700–716 (2012)
Wang, H., et al.: Identifying quantitative trait loci via group-sparse multitask regression and feature selection: an imaging genetics study of the ADNI cohort. Bioinformatics 28(2), 229–237 (2012)
Zheng, W., Zhu, X., Wen, G., Zhu, Y., Yu, H., Gan, J.: Unsupervised feature selection by self-paced learning regularization. Pattern Recogn. Lett. https://doi.org/10.1016/j.patrec.2018.06.029 (2018)
Zheng, W., Zhu, X., Zhu, Y., Hu, R., Lei, C.: Dynamic graph learning for spectral feature selection. Multimed. Tools Appl. 77(22), 29739–29755 (2018)
Zhu, H., et al.: Bayesian generalized low rank regression models for neuroimaging phenotypes and genetic markers. J. Am. Stat. Assoc. 109(507), 977–990 (2014)
Zhu, X., Li, X., Zhang, S.: Block-row sparse multiview multilabel learning for image classification. IEEE Trans. Cybern. 46(2), 450–461 (2016)
Zhu, X., Li, X., Zhang, S., Xu, Z., Yu, L., Wang, C.: Graph PCA hashing for similarity search. IEEE Trans. Multimed. 19(9), 2033–2044 (2017)
Zhu, X., Suk, H.I., Wang, L., Lee, S.W., Shen, D., Alzheimer’s Disease Neuroimaging Initiative: A novel relational regularization feature selection method for joint regression and classification in AD diagnosis. Med. Image Anal. 38, 205–214 (2017)
Zhu, X., Zhang, S., Hu, R., He, W., Lei, C., Zhu, P.: One-step multi-view spectral clustering. IEEE Trans. Knowl. Data Eng. (2018). https://doi.org/10.1109/TKDE.2018.2873378
Zhu, X., Suk, H.-I., Huang, H., Shen, D.: Structured sparse low-rank regression model for brain-wide and genome-wide associations. In: Ourselin, S., Joskowicz, L., Sabuncu, M.R., Unal, G., Wells, W. (eds.) MICCAI 2016. LNCS, vol. 9900, pp. 344–352. Springer, Cham (2016). https://doi.org/10.1007/978-3-319-46720-7_40
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Zhu, X., Shen, D. (2019). Robust and Discriminative Brain Genome Association Study. In: Shen, D., et al. Medical Image Computing and Computer Assisted Intervention – MICCAI 2019. MICCAI 2019. Lecture Notes in Computer Science(), vol 11767. Springer, Cham. https://doi.org/10.1007/978-3-030-32251-9_50
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DOI: https://doi.org/10.1007/978-3-030-32251-9_50
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