Abstract
A stenosis is a coronary artery disease (CAD) that poses a high risk to the patient’s life by narrowing or blocking completely the vessel. Critical luminal narrowings (i.e. significant stenoses) require urgent intervention, and thus, detecting these cases among all stenoses is vitally important. The performance of previous methods for automatically classifying significant stenosis is limited by the use of hand-crafted features or generic features that cannot represent properly the characteristics of this CAD. In this paper, we present a novel method for automatic classification of significant stenosis from coronary CT angiography scans (CCTA). Our method leverages a state-of-the-art feature extractor for texture classification that describe effectively the appearance of significant stenosis. We extract features from curved planar reformation (CPR) views of the coronary arteries: axial, sagittal, coronal, and two orthogonal diagonal-views. The final decision is made by an ensemble of the classification probabilities of each view, similar to the procedure radiologists follow in the diagnosis of significant stenosis. We evaluate our method using a CCTA-CPR dataset of 57 patients with ground truth annotations provided by three experienced experts (significant stenosis if luminal narrowing \(\ge \) \(50\%\)). The results of our cross-validated experiments show state-of-the-art classification performance.
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Notes
- 1.
Authors consider no stenosis and non-significant stenosis as two different classes.
- 2.
The clusters in the CNN features are tSNE artifacts, with no particular meaning.
References
Cetin, S., Unal, G.: Automatic detection of coronary artery stenosis in CTA based on vessel intensity and geometric features. In: Proceedings of the MICCAI Workshop. 3D Cardiovascular Imaging (2012)
Cimpoi, M., Maji, S., Vedaldi, A.: Deep filter banks for texture recognition and segmentation. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 3828–3836 (2015)
Dewey, M., Rutsch, W., Schnapauff, D., Teige, F., Hamm, B.: Coronary artery stenosis quantification using multislice computed tomography. Invest. Radiol. 42(2), 78–84 (2007)
Duval, M., Ouzeau, E., Precioso, F., Matuszewski, B.: Coronary artery stenoses detection with random forest. In: Proceedings of the MICCAI Workshop, 3D Cardiovascular Imaging (2012)
Kelm, B.M., et al.: Detection, grading and classification of coronary stenoses in computed tomography angiography. In: Fichtinger, G., Martel, A., Peters, T. (eds.) MICCAI 2011. LNCS, vol. 6893, pp. 25–32. Springer, Heidelberg (2011). https://doi.org/10.1007/978-3-642-23626-6_4
Sankaran, S., Schaap, M., Hunley, S.C., Min, J.K., Taylor, C.A., Grady, L.: HALE: healthy area of lumen estimation for vessel stenosis quantification. In: Ourselin, S., Joskowicz, L., Sabuncu, M.R., Unal, G., Wells, W. (eds.) MICCAI 2016. LNCS, vol. 9902, pp. 380–387. Springer, Cham (2016). https://doi.org/10.1007/978-3-319-46726-9_44
Shahzad, R., et al.: Automatic segmentation, detection and quantification of coronary artery stenoses on CTA. Int. J. Cardiovasc. Imaging 29(8), 1847–1859 (2013)
Shen, D., Wu, G., Suk, H.I.: Deep learning in medical image analysis. Annu. Rev. Biomed. Eng. 19, 221–248 (2017)
Shin, H.C., et al.: Deep convolutional neural networks for computer-aided detection: CNN architectures, dataset characteristics and transfer learning. IEEE Trans. Med. Imaging 35(5), 1285–1298 (2016)
Simonyan, K., Zisserman, A.: Very deep convolutional networks for largescale image recognition. In: Proceedings of the International Conference on Learning Representations, pp. 1–14 (2015)
Tessmann, M., Vega-Higuera, F., Fritz, D., Scheuering, M., Greiner, G.: Multi-scale feature extraction for learning-based classification of coronary artery stenosis. In: Proceedings of the SPIE Medical Imaging: Computer-Aided Diagnosis, pp. 726002:1–726002:8 (2009)
Wolterink, J.M., Leiner, T., de Vos, B.D., van Hamersvelt, R.W., Viergever, M.A., Išgum, I.: Automatic coronary artery calcium scoring in cardiac CT angiography using paired convolutional neural networks. Med. Image Anal. 34, 123–136 (2016)
Zreik, M., van Hamersvelt, R.W., Wolterink, J.M., Leiner, T., Viergever, M.A., Išgum, I.: A recurrent CNN for automatic detection and classification of coronary artery plaque and stenosis in coronary CT angiography. IEEE Trans. Med. Imaging 1(1), 1–11 (2018)
Zreik, M., et al.: Deep learning analysis of the myocardium in coronary CT angiography for identification of patients with functionally significant coronary artery stenosis. Med. Image Anal. 44, 72–85 (2018)
Zuluaga, M.A., Magnin, I.E., Hernández-Hoyos, M., Delgado-Leyton, E.J., Lozano, F., Orkisz, M.: Automatic detection of abnormal vascular cross-sections based on density level detection and support vector machines. Int. J. Comput. Assist. Radiol. Surg. 6(2), 163–174 (2011)
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Tejero-de-Pablos, A. et al. (2019). Texture-Based Classification of Significant Stenosis in CCTA Multi-view Images of Coronary Arteries. In: Shen, D., et al. Medical Image Computing and Computer Assisted Intervention – MICCAI 2019. MICCAI 2019. Lecture Notes in Computer Science(), vol 11765. Springer, Cham. https://doi.org/10.1007/978-3-030-32245-8_81
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