Solution-Based Dosage Forms and Sterile Products

  • Ashlee D. Brunaugh
  • Hugh D. C. Smyth
  • Robert O. Williams III
Part of the AAPS Introductions in the Pharmaceutical Sciences book series (AAPSINSTR)


This chapter expands upon the concept of drug solubility and dissolution as it relates to dosage form design. Excipients utilized in solution-based dosage forms and parenteral products are discussed in detail, including solvents, cosolvents, antioxidants, preservatives, complexing agents, and surfactants. Special considerations which must be made for parenteral dosage forms are introduced. Lastly, a review of lyophilization and sterilization techniques is provided.


Sterile product Intravenous administration Intramuscular administration Parenteral drug delivery Solubility Lyophilization Dissolution Surfactant Injectable Sterilization 

Further Reading

  1. Suggested readings for the student include the following texts:Google Scholar
  2. 1.
    Fricker G, Kromp T, Wendel A, Blume A, Zirkel J, Rebmann H, Setzer C, Quinkert RO, Martin F, Müller-Goymann C. Phospholipids and lipid-based formulations in oral drug delivery. Pharm Res. 2010;27(8):1469–86.CrossRefGoogle Scholar
  3. 2.
    Gatlin LA, Auffret T, Shalaev EY, Speaker SM, Teagarden DL. Freeze-drying concepts: the basics. In: Protein formulation and delivery. 2nd ed. Boca Raton: CRC; 2007. p. 195–214.Google Scholar
  4. 3.
    Surasarang SH, Williams RO. Co-solvent and complexation systems. In: Formulating poorly water soluble drugs. 2nd ed. New York: Springer; 2016. p. 215–56.CrossRefGoogle Scholar

Copyright information

© American Association of Pharmaceutical Scientists 2019

Authors and Affiliations

  • Ashlee D. Brunaugh
    • 1
  • Hugh D. C. Smyth
    • 1
  • Robert O. Williams III
    • 1
  1. 1.College of PharmacyThe University of Texas at AustinAustinUSA

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