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Capsule and Tablet Dosage Forms

  • Ashlee D. Brunaugh
  • Hugh D. C. Smyth
  • Robert O. Williams III
Chapter
Part of the AAPS Introductions in the Pharmaceutical Sciences book series (AAPSINSTR)

Abstract

This chapter provides an overview of the design, manufacturing, and formulation of capsule and tablet-based drug products. Manufacturing methods for producing both capsules and tablets are extensively discussed, and figures are incorporated to aid student understanding. Frequently used excipient categories are provided along with general functions and examples. A review of USP-recommended analytical tests is also included. Lastly, this chapter introduces techniques for formulating poorly water soluble drugs in capsule and tablet dosage forms.

Keywords

Capsule Tablet Amorphous solid dispersion Film-coating Tablet manufacturing Pharmaceutical excipients Poorly water soluble Pharmaceutical analysis Analytical methods 

Further Reading

  1. Suggested readings for the student include the following texts:Google Scholar
  2. 1.
    Huang S, Mao C, Williams RO III, Yang CY. Solubility advantage (and disadvantage) of pharmaceutical amorphous solid dispersions. J Pharm Sci. 2016;105(12):3549–61.CrossRefGoogle Scholar
  3. 2.
    Jermain SV, Brough C, Williams RO III. Amorphous solid dispersions and nanocrystal technologies for poorly water-soluble drug delivery–an update. Int J Pharm. 2018;535(1–2):379–92.CrossRefGoogle Scholar
  4. 3.
    Liu X, Feng X, Williams RO, Zhang F. Characterization of amorphous solid dispersions. J Pharm Investig. 2018;48(1):19–41.CrossRefGoogle Scholar
  5. 4.
    Ma X, Williams RO III. Characterization of amorphous solid dispersions: an update. J Drug Deliv Sci Technol. 2019;50:113–24.CrossRefGoogle Scholar
  6. 5.
    Varum FJ, Hatton GB, Basit AW. Food, physiology and drug delivery. Int J Pharm. 2013;457(2):446–60.CrossRefGoogle Scholar
  7. 6.
    Huang S, Mao C, Williams RO III, Yang C-Y. Solubility advantage (and disadvantage) of pharmaceutical amorphous solid dispersions. J Pharm Sci. 2016;105:3549–61.CrossRefGoogle Scholar

Copyright information

© American Association of Pharmaceutical Scientists 2019

Authors and Affiliations

  • Ashlee D. Brunaugh
    • 1
  • Hugh D. C. Smyth
    • 1
  • Robert O. Williams III
    • 1
  1. 1.College of PharmacyThe University of Texas at AustinAustinUSA

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