This chapter provides an overview of the design, manufacturing, and formulation of capsule and tablet-based drug products. Manufacturing methods for producing both capsules and tablets are extensively discussed, and figures are incorporated to aid student understanding. Frequently used excipient categories are provided along with general functions and examples. A review of USP-recommended analytical tests is also included. Lastly, this chapter introduces techniques for formulating poorly water soluble drugs in capsule and tablet dosage forms.
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Suggested readings for the student include the following texts:Google Scholar
Huang S, Mao C, Williams RO III, Yang CY. Solubility advantage (and disadvantage) of pharmaceutical amorphous solid dispersions. J Pharm Sci. 2016;105(12):3549–61.CrossRefGoogle Scholar
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Varum FJ, Hatton GB, Basit AW. Food, physiology and drug delivery. Int J Pharm. 2013;457(2):446–60.CrossRefGoogle Scholar
Huang S, Mao C, Williams RO III, Yang C-Y. Solubility advantage (and disadvantage) of pharmaceutical amorphous solid dispersions. J Pharm Sci. 2016;105:3549–61.CrossRefGoogle Scholar