Pulmonary Drug Delivery
This chapter provides an introductory overview on concepts related to drug delivery to the lungs. Physiological barriers to lung delivery are examined, as are the mechanisms for overcoming these barriers through delivery device and formulation design. A review is provided of delivery mechanisms and design of the three major classes of pulmonary drug delivery devices (pressurized metered dose inhalers, nebulizers, and dry powder inhalers). For each class of device, appropriate formulation approaches are discussed.
KeywordsNebulizer Pressurized metered dose inhaler Dry powder inhaler Orally inhaled drug products Pulmonary drug delivery Pulmonary device design Powder dispersion Lung deposition
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