Nanovaccines pp 131-157 | Cite as

Nanogels-Based Mucosal Vaccines

  • Sergio Rosales-Mendoza
  • Omar González-Ortega


Innovative vaccines are required to fight human and animal diseases. Improved immunogenicity, safety, easy administration, and low cost are among the innovations that are pursued in this field. Nanogels are materials with attractive features to meet these requirements; they consist of solid, jelly like materials produced by crosslinking of synthetic or natural polymers (or a combination of both) with a high water-holding capacity. Herein, the state of the art of nanogels-based vaccines is provided. Synthesis and functionalization methods for nanogels are described. Thus far, several groups have evaluated nanogels as vaccine delivery vehicles leading to promising data for nanovaccines against cancer, obesity, and infectious diseases. The most advanced candidates are nanovaccines against cancer, based on cholesteryl pullulan nanogels, that have been evaluated in clinical trials revealing proper immunogenicity and safety. The key perspectives for this topic include expanding the assessment of mucosal vaccines and implementing green syntheses approaches, which could lead to lower production cost and enhanced safety.


Cholesteryl pullulan nanogels Chemical crosslinking Physical crosslinking Radical polymerization 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Sergio Rosales-Mendoza
    • 1
  • Omar González-Ortega
    • 2
  1. 1.Facultad de Ciencias Químicas, Centro de Investigación en Ciencias de la Salud y BiomedicinaUniversidad Autónoma de San Luis PotosíSan Luis PotosíMexico
  2. 2.Facultad de Ciencias QuímicasUniversidad Autónoma de San Luis Potosí San Luis PotosíMexico

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