Nanoparticles for Cornea Therapeutic Applications: Treating Herpes Simplex Viral Infections
Herpes Simplex Virus-1 (HSV-1) infections in the eye often originate in the cornea before assuming a latent state in the trigeminal ganglion. During primary infection and upon injury or reactivation, HSV-1 can lead to significant corneal damage. Nanoparticles (NPs) are an emerging strategy for drug delivery to the cornea because they improve the long-term release of anti-HSV-1 drugs, such as nucleoside analogues. Acyclovir, ganciclovir, and valacyclovir have been successfully delivered using both polymer and lipid-based NPs in vitro. Solid silica dioxide NPs have been used to deliver the cathelicidin, LL-37, which prevented HSV-1 infection in corneal epithelial cells. Iron oxide nanoparticles have also been adapted to deliver an anti-HSV-1 DNA vaccine that successfully reduced corneal opacity and HSV-1 markers in a mouse model. Overall, NPs show promise as a delivery method for anti-HSV-1 strategies.
The authors have no conflict of interest. FS is supported by a FRQNT PhD studentship. FXG is supported by a (Berthe Fouassier) France Foundation studentship. MG holds the Caroline Durand Foundation Research Chair for Cellular Therapy of Diseases of the Eye, Université de Montréal.
All authors have read and approved the final version.
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