Calcium Signaling in Glioma Cells: The Role of Nucleotide Receptors

  • Dorota Wypych
  • Paweł PomorskiEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1202)


Calcium signaling is probably one of the evolutionary oldest and the most common way by which the signal can be transmitted from the cell environment to the cytoplasmic calcium binding effectors. Calcium signal is fast and due to diversity of calcium binding proteins it may have a very broad effect on cell behavior. Being a crucial player in neuronal transmission it is also very important for glia physiology. It is responsible for the cross-talk between neurons and astrocytes, for microglia activation and motility. Changes in calcium signaling are also crucial for the behavior of transformed glioma cells. The present chapter summarizes molecular mechanisms of calcium signal formation present in glial cells with a strong emphasis on extracellular nucleotide-evoked signaling pathways. Some aspects of glioma C6 signaling such as the cross-talk between P2Y1 and P2Y12 nucleotide receptors in calcium signal generation will be discussed in-depth, to show complexity of machinery engaged in formation of this signal. Moreover, possible mechanisms of modulation of the calcium signal in diverse environments there will be presented herein. Finally, the possible role of calcium signal in glioma motility is also discussed. This is a very important issue, since glioma cells, contrary to the vast majority of neoplastic cells, cannot spread in the body with the bloodstream and, at least in early stages of tumor development, may expand only by means of sheer motility.


Calcium signaling Nucleotide receptors Store-operated calcium entry 



2-methylthio ADP




Endoplasmic reticulum


G-protein coupled receptor


Inositol (1,4,5) trisphosphate


IP3 receptor


Myosin light chain


Sodium/calcium exchanger


Phosphatidylinositol 3-kinase


Phosphatidylinositol 4,5-biphosphate


Phospholipase C


Plasma membrane


Plasma membrane calcium ATPase


Point spread function


Ryanodine receptor


Sarco/endoplasmic reticulum calcium ATPase


Store-operated channel


Store-operated calcium entry


Stromal interaction molecule 1,2

TRP channel

Transient receptor potential channel


Ankyrin transient receptor potential channel


Canonical transient receptor potential channel


Melastatin transient receptor potential channel


Vanilloid transient receptor potential channel


Voltage-gated calcium channels



Authors were supported by grant UMO-2015/17/B/NZ3/03771 from Nntional Science Center, Poland.


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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Nencki Institute of Experimental BiologyPolish Academy of SciencesWarsawPoland

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