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Factors Affecting Response and Survival in Radiotherapy

  • Michael AwadallahEmail author
  • Kurt Nisi
  • Ketan J. Patel
Chapter
First Online:

Abstract

We are investigating the different variables that can potentially affect tumor response to radiation therapy. These factors can be tumor-specific, patient-specific, therapy-specific, or a combination of these variables. Noteworthy factors include extranodal extension, tumor microenvironment, time to adjunctive radiation therapy, tumor volume, margin status, adjunctive concurrent chemotherapy, and fractionation schedule/dose. This chapter sheds light on how the previously mentioned factors can potentially impact the efficacy of radiation treatment on locoregional recurrence, overall survival, and disease-free specific survival as a treatment modality for oral cancer.

Keywords

Radiation therapy Efficacy Extranodal extension Margin status Fractionation dose Tumor volume Locoregional control Chemotherapy 
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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Oral and Maxillofacial SurgeryNorth Memorial Medical CenterMinneapolisUSA
  2. 2.Minneapolis Radiation OncologyMinneapolisUSA

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