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Surgical Factors Affecting Outcomes in Oral Squamous Cell Carcinoma

  • Justine Moe
  • Andrew Baker
  • Brent WardEmail author
Chapter

Abstract

Surgery is the primary treatment modality for oral cavity squamous cell carcinoma (OCSCC). Care team factors, patient factors, and procedure-related factors affect surgical outcomes and overall prognosis. The management of the primary tumor per oral cavity subsite, the management of the neck, and the evaluation of margin status are fundamental surgical principles. In addition, dental rehabilitation is an important functional consideration in the reconstruction following tumor ablation. The use of adjunct surgical tools including surgical navigation and virtual surgery planning allows for patient-specific and highly precise bony ablation and reconstruction. Evidence-based surgical decision-making can optimize treatment outcomes and improve survival.

Keywords

Oral cancer Tumor resection Ablative surgery Reconstructive surgery Free flap reconstruction Margin status Neck dissection Sentinel node biopsy Dental rehabilitation Surgical navigation 

Notes

Acknowledgements

The authors would like to acknowledge Raea Bucher, illustrator, for providing Figs. 5.15.5 and 5.10 for this chapter.

References

  1. 1.
    Global Cancer Observatory. Cancer today. http://gco.iarc.fr/today/fact-sheets-populations. Accessed 23 Sep 2018.
  2. 2.
    National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology. https://www.nccn.org/professionals/physician_gls/default.aspx. Accessed 23 Sep 2018.
  3. 3.
    Schwam ZG, Judson BL. Improved prognosis for patients with oral cavity squamous cell carcinoma: analysis of the National Cancer Database 1998–2006. Oral Oncol. 2016;52:45.PubMedCrossRefGoogle Scholar
  4. 4.
    Piccirillo JF. Importance of comorbidity in head and neck cancer. Laryngoscope. 2000;110:593.PubMedCrossRefGoogle Scholar
  5. 5.
    Paleri V, Wight RG, Silver CE, Haigentz M, Takes RP, Bradley PJ, Rinaldo A, Sanabria A, Bień S, Ferlito A. Comorbidity in head and neck cancer: a critical appraisal and recommendations for practice. Oral Oncol. 2010;46:712.PubMedCrossRefGoogle Scholar
  6. 6.
    Ferrier MB, Spuesens EB, Le Cessie S, Baatenburg de Jong RJ. Comorbidity as a major risk factor for mortality and complications in head and neck surgery. Arch Otolaryngol Head Neck Surg. 2005;131:27.PubMedCrossRefGoogle Scholar
  7. 7.
    Jun MY, Strong EW, Saltzman EI, Gerold FP. Head and neck cancer in the elderly. Head Neck. 1983;5:376.CrossRefGoogle Scholar
  8. 8.
    Yamada S-I, Kurita H, Tomioka T, Ohta R, Yoshimura N, Nishimaki F, Koyama Y, Kondo E, Kamata T. Healthy life expectancy of oral squamous cell carcinoma patients aged 75 years and older. Oral Oncol. 2017;64:22.PubMedCrossRefGoogle Scholar
  9. 9.
    Datema FR, Ferrier MB, van der Schroeff MP, de Jong RJB. Impact of comorbidity on short-term mortality and overall survival of head and neck cancer patients. Head Neck. 2010;32:728.PubMedCrossRefGoogle Scholar
  10. 10.
    Pogrel MA, Podlesh S, Anthony JP, Alexander J. A comparison of vascularized and nonvascularized bone grafts for reconstruction of mandibular continuity defects. J Oral Maxillofac Surg. 1997;55:1200.PubMedCrossRefGoogle Scholar
  11. 11.
    McGregor AD, MacDonald DG. Patterns of spread of squamous cell carcinoma to the ramus of the mandible. Head Neck. 1993;15:440.PubMedCrossRefGoogle Scholar
  12. 12.
    He Y, Zhang ZY, Zhu HG, Sader R, He J, Kovács AF. Free fibula osteocutaneous flap for primary reconstruction of T3–T4 gingival carcinoma. J Craniofac Surg. 2010;21:301.PubMedCrossRefGoogle Scholar
  13. 13.
    Pandey M, Rao LP, Das SR, Mathews A, Chacko EM, Naik BR. Patterns of mandibular invasion in oral squamous cell carcinoma of the mandibular region. World J Surg Oncol. 2007;5:12.PubMedPubMedCentralCrossRefGoogle Scholar
  14. 14.
    Jewer DD, Boyd JB, Manktelow RT, Zuker RM, Rosen IB, Gullane PJ, Rotstein LE, Freeman JE. Orofacial and mandibular reconstruction with the iliac crest free flap: a review of 60 cases and a new method of classification. Plast Reconstr Surg. 1989;84:391.PubMedCrossRefGoogle Scholar
  15. 15.
    Urken ML, Vickery C, Weinberg H, Buchbinder D, Lawson W, Biller HF. The internal oblique-iliac crest osseomyocutaneous free flap in oromandibular reconstruction: report of 20 cases. Arch Otolaryngol Head Neck Surg. 1989;115:339.PubMedCrossRefGoogle Scholar
  16. 16.
    Kekatpure VD, Manjula BV, Mathias S, Trivedi NP, Selvam S, Kuriakose MA. Reconstruction of large composite buccal defects using single soft tissue flap—analysis of functional outcome. Microsurgery. 2013;33:184.PubMedCrossRefGoogle Scholar
  17. 17.
    Brown JS, Rogers SN, McNally DN, Boyle M. A modified classification for the maxillectomy defect. Head Neck. 2000;22:17.PubMedCrossRefGoogle Scholar
  18. 18.
    Okay DJ, Genden E, Buchbinder D, Urken M. Prosthodontic guidelines for surgical reconstruction of the maxilla: a classification system of defects. J Prosthet Dent. 2001;86:352.PubMedPubMedCentralCrossRefGoogle Scholar
  19. 19.
    Maniglia AJ. Indications and techniques of midfacial degloving: a 15-year experience. Arch Otolaryngol Head Neck Surg. 1986;112:750.PubMedCrossRefGoogle Scholar
  20. 20.
    Davison SP, Sherris DA, Meland NB. An algorithm for maxillectomy defect reconstruction. Laryngoscope. 1998;108:215.PubMedCrossRefGoogle Scholar
  21. 21.
    Sharaf MY, Ibrahim SI, Eskander AE, Shaker AF. Prosthetic versus surgical rehabilitation in patients with maxillary defect regarding the quality of life: systematic review. Oral Maxillofac Surg. 2018;22:1.PubMedCrossRefGoogle Scholar
  22. 22.
    Futran ND, Wadsworth JT, Villaret D, Farwell DG. Midface reconstruction with the fibula free flap. Arch Otolaryngol Head Neck Surg. 2002;128:161.PubMedCrossRefGoogle Scholar
  23. 23.
    Uglešić V, Virag M, Varga S, Knežević P, Milenović A. Reconstruction following radical maxillectomy with flaps supplied by the subscapular artery. J Cranio-Maxillofac Surg. 2000;28:153.CrossRefGoogle Scholar
  24. 24.
    Moreno MA, Skoracki RJ, Hanna EY, Hanasono MM. Microvascular free flap reconstruction versus palatal obturation for maxillectomy defects. Head Neck. 2010;32:860.PubMedCrossRefGoogle Scholar
  25. 25.
    Li W, Li R, Safdar J, Huang S, Xu Z, Tan X, Sun C. Modified visor approach applied to total or subtotal glossectomy and reconstruction: avoidance of lip splitting and mandibulotomy and cutting off mental nerve. Tumour Biol. 2014;35:7847.PubMedCrossRefGoogle Scholar
  26. 26.
    Yuen PW, Lam KY, Chan AC, Wei WI, Lam LK. Clinicopathological analysis of local spread of carcinoma of the tongue. Am J Surg. 1998;175:242.PubMedCrossRefGoogle Scholar
  27. 27.
    Guerin-Lebailly C, Mallet Y, Lambour V, Fournier C, Bedoui El S, Ton Van J, Lefebvre JL. Functional and sensitive outcomes after tongue reconstruction: about a series of 30 patients. Oral Oncol. 2012;48:272.PubMedCrossRefGoogle Scholar
  28. 28.
    Kuriakose MA, Loree TR, Spies A, Meyers S, Hicks WL. Sensate radial forearm free flaps in tongue reconstruction. Arch Otolaryngol Head Neck Surg. 2001;127:1463.PubMedCrossRefGoogle Scholar
  29. 29.
    Namin AW, Varvares MA. Functional outcomes of sensate versus insensate free flap reconstruction in oral and oropharyngeal reconstruction: a systematic review. Head Neck. 2016;38:1717.PubMedCrossRefGoogle Scholar
  30. 30.
    Dziegielewski PT, Ho ML, Rieger J, Singh P, Langille M, Harris JR, Seikaly H. Total glossectomy with laryngeal preservation and free flap reconstruction: objective functional outcomes and systematic review of the literature. Laryngoscope. 2013;123:140.PubMedCrossRefPubMedCentralGoogle Scholar
  31. 31.
    Lin DT, Yarlagadda BB, Sethi RKV, Feng AL, Shnayder Y, Ledgerwood LG, Diaz JA, Sinha P, Hanasono MM, Yu P, Skoracki RJ, Lian TS, Patel UA, Leibowitz J, Purdy N, Starmer H, Richmon JD. Long-term functional outcomes of total glossectomy with or without total laryngectomy. JAMA Otolaryngol Head Neck Surg. 2015;141:797.PubMedCrossRefGoogle Scholar
  32. 32.
    Lubek JE, Clayman L. An update on squamous carcinoma of the oral cavity, oropharynx, and maxillary sinus. Oral Maxillofac Surg Clin North Am. 2012;24:307.PubMedCrossRefPubMedCentralGoogle Scholar
  33. 33.
    Niu LX, Feng Z, Li JN, Li CZ, Peng X, Guo CB. Prognostic factors of squamous cell carcinoma of the buccal mucosa: a retrospective study of 168 cases in North China. J Oral Maxillofac Surg. 2014;72:2344.PubMedCrossRefGoogle Scholar
  34. 34.
    Lin C-S, Jen Y-M, Cheng M-F, Lin Y-S, Su W-F, Hwang J-M, Chang L-P, Chao H-L, Liu D-W, Lin H-Y, Shum W-Y. Squamous cell carcinoma of the buccal mucosa: an aggressive cancer requiring multimodality treatment. Head Neck. 2006;28:150.PubMedCrossRefPubMedCentralGoogle Scholar
  35. 35.
    Jan J-C, Hsu W-H, Liu S-A, Wong Y-K, Poon C-K, Jiang R-S, Jan J-S, Chen IF. Prognostic factors in patients with buccal squamous cell carcinoma: 10-year experience. J Oral Maxillofac Surg. 2011;69:396.PubMedCrossRefGoogle Scholar
  36. 36.
    Chiou W-Y, Lin H-Y, Hsu F-C, Lee M-S, Ho H-C, Su Y-C, Lee C-C, Hsieh C-H, Wang Y-C, Hung S-K. Buccal mucosa carcinoma: surgical margin less than 3 mm, not 5 mm, predicts locoregional recurrence. Radiat Oncol. 2010;5:79.PubMedPubMedCentralCrossRefGoogle Scholar
  37. 37.
    Moe J, Helman JI. Surgical techniques for the management of submandibular salivary duct strictures. Atlas Oral Maxillofac Surg Clin. 2018;26:99.CrossRefGoogle Scholar
  38. 38.
    Kurita H, Nakanishi Y, Nishizawa R, Xiao T, Kamata T, Koike T, Kobayashi H. Impact of different surgical margin conditions on local recurrence of oral squamous cell carcinoma. Oral Oncol. 2010;46:814.PubMedCrossRefPubMedCentralGoogle Scholar
  39. 39.
    Loree TR, Strong EW. Significance of positive margins in oral cavity squamous carcinoma. Am J Surg. 1990;160:410.PubMedCrossRefGoogle Scholar
  40. 40.
    Ravasz LA, Slootweg PJ, Hordijk GJ, Smit F, van der Tweel I. The status of the resection margin as a prognostic factor in the treatment of head and neck carcinoma. J Cranio-Maxillofac Surg. 1991;19:314.CrossRefGoogle Scholar
  41. 41.
    Jacobs JR, Ahmad K, Casiano R, Schuller DE, Scott C, Laramore GE, Sarraf Al M. Implications of positive surgical margins. Laryngoscope. 1993;103:64.PubMedCrossRefGoogle Scholar
  42. 42.
    Binahmed A, Nason RW, Abdoh AA. The clinical significance of the positive surgical margin in oral cancer. Oral Oncol. 2007;43:780.PubMedCrossRefGoogle Scholar
  43. 43.
    Chang AMV, Kim SW, Duvvuri U, Johnson JT, Myers EN, Ferris RL, Gooding WE, Seethala RR, Chiosea SI. Early squamous cell carcinoma of the oral tongue: comparing margins obtained from the glossectomy specimen to margins from the tumor bed. Oral Oncol. 2013;49:1077.PubMedCrossRefGoogle Scholar
  44. 44.
    Anderson CR, Sisson K, Moncrieff M. A meta-analysis of margin size and local recurrence in oral squamous cell carcinoma. Oral Oncol. 2015;51:464.PubMedCrossRefPubMedCentralGoogle Scholar
  45. 45.
    Byers RM, Bland KI, Borlase B, Luna M. The prognostic and therapeutic value of frozen section determinations in the surgical treatment of squamous carcinoma of the head and neck. Am J Surg. 1978;136:525.PubMedCrossRefGoogle Scholar
  46. 46.
    Chen TY, Emrich LJ, Driscoll DL. The clinical significance of pathological findings in surgically resected margins of the primary tumor in head and neck carcinoma. Int J Rad Oncol Biol Phys. 1987;13:833.CrossRefGoogle Scholar
  47. 47.
    Jones AS. Prognosis in mouth cancer: tumour factors. Eur J Cancer B Oral Oncol. 1994;30:8.CrossRefGoogle Scholar
  48. 48.
    Scholl P, Byers RM, Batsakis JG, Wolf P, Santini H. Microscopic cut-through of cancer in the surgical treatment of squamous carcinoma of the tongue: prognostic and therapeutic implications. Am J Surg. 1986;152:354.PubMedCrossRefPubMedCentralGoogle Scholar
  49. 49.
    Sieczka E, Datta R, Singh A, Loree T, Rigual N, Orner J, Hicks W Jr. Cancer of the buccal mucosa: are margins and T-stage accurate predictors of local control? Am J Otolaryngol. 2001;22:395.PubMedCrossRefPubMedCentralGoogle Scholar
  50. 50.
    Brandwein-Gensler M, Teixeira MS, Lewis CM, Lee B, Rolnitzky L, Hille JJ, Genden E, Urken ML, Wang BY. Oral squamous cell carcinoma: histologic risk assessment, but not margin status, is strongly predictive of local disease-free and overall survival. Am J Surg Pathol. 2005;29:167.PubMedPubMedCentralCrossRefGoogle Scholar
  51. 51.
    Colevas AD, Yom SS, Pfister DG, Spencer S, Adelstein D, Adkins D, Brizel DM, Burtness B, Busse PM, Caudell JJ, Cmelak AJ, Eisele DW, Fenton M, Foote RL, Gilbert J, Gillison ML, Haddad RI, Hicks WL, Hitchcock YJ, Jimeno A, Leizman D, Maghami E, Mell LK, Mittal BB, Pinto HA, Ridge JA, Rocco J, Rodriguez CP, Shah JP, Weber RS, Witek M, Worden F, Zhen W, Burns JL, Darlow SD. NCCN guidelines insights: head and neck cancers, version 1.2018. J Natl Compr Canc Netw. 2018;16:479.PubMedCrossRefGoogle Scholar
  52. 52.
    Zanoni DK, Migliacci JC, Xu B, Katabi N, Montero PH, Ganly I, Shah JP, Wong RJ, Ghossein RA, Patel SG. A proposal to redefine close surgical margins in squamous cell carcinoma of the oral tongue. JAMA Otolaryngol Head Neck Surg. 2017;143:555.PubMedPubMedCentralCrossRefGoogle Scholar
  53. 53.
    Mistry RC, Qureshi SS, Kumaran C. Post-resection mucosal margin shrinkage in oral cancer: quantification and significance. J Surg Oncol. 2005;91:131.PubMedCrossRefGoogle Scholar
  54. 54.
    Hinni ML, Ferlito A, Brandwein-Gensler MS, Takes RP, Silver CE, Westra WH, Seethala RR, Rodrigo JP, Corry J, Bradford CR, Hunt JL, Strojan P, Devaney KO, Gnepp DR, Hartl DM, Kowalski LP, Rinaldo A, Barnes L. Surgical margins in head and neck cancer: a contemporary review. Head Neck. 2013;35:1362.PubMedCrossRefGoogle Scholar
  55. 55.
    Cheng A, Cox D, Schmidt BL. Oral squamous cell carcinoma margin discrepancy after resection and pathologic processing. J Oral Maxillofac Surg. 2008;66:523.PubMedCrossRefGoogle Scholar
  56. 56.
    Du E, Ow TJ, Lo Y-T, Gersten A, Schiff BA, Tassler AB, Smith RV. Refining the utility and role of frozen section in head and neck squamous cell carcinoma resection. Laryngoscope. 2016;126:1768.PubMedCrossRefGoogle Scholar
  57. 57.
    DiNardo LJ, Lin J, Karageorge LS, Powers CN. Accuracy, utility, and cost of frozen section margins in head and neck cancer surgery. Laryngoscope. 2000;110:1773.PubMedCrossRefGoogle Scholar
  58. 58.
    Ord RA, Aisner S. Accuracy of frozen sections in assessing margins in oral cancer resection. J Oral Maxillofac Surg. 1997;55:663.PubMedCrossRefGoogle Scholar
  59. 59.
    Ettl T, El-Gindi A, Hautmann M, Gosau M, Weber F, Rohrmeier C, Gerken M, Müller S, Reichert T, Klingelhöffer C. Positive frozen section margins predict local recurrence in R0-resected squamous cell carcinoma of the head and neck. Oral Oncol. 2016;55:17.PubMedCrossRefGoogle Scholar
  60. 60.
    Patel RS, Goldstein DP, Guillemaud J, Bruch GA, Brown D, Gilbert RW, Gullane PJ, Higgins KM, Irish J, Enepekides DJ. Impact of positive frozen section microscopic tumor cut-through revised to negative on oral carcinoma control and survival rates. Head Neck. 2010;32:1444.PubMedCrossRefGoogle Scholar
  61. 61.
    Varvares MA, Poti S, Kenyon B, Christopher K, Walker RJ. Surgical margins and primary site resection in achieving local control in oral cancer resections. Laryngoscope. 2015;125:2298.PubMedCrossRefGoogle Scholar
  62. 62.
    Kerawala CJ, Ong TK. Relocating the site of frozen sections? Is there room for improvement? Head Neck. 2001;23:230.PubMedCrossRefGoogle Scholar
  63. 63.
    Shapiro M, Salama A. Margin analysis: squamous cell carcinoma of the oral cavity. Oral Maxillofac Surg Clin. 2017;29:259.CrossRefGoogle Scholar
  64. 64.
    Yahalom R, Dobriyan A, Vered M, Talmi YP, Teicher S, Bedrin L. A prospective study of surgical margin status in oral squamous cell carcinoma: a preliminary report. J Surg Oncol. 2008;98:572.PubMedCrossRefGoogle Scholar
  65. 65.
    Chiosea SI. Intraoperative margin assessment in early oral squamous cell carcinoma. Surg Pathol Clin. 2017;10:1.PubMedCrossRefGoogle Scholar
  66. 66.
    Arick Forrest L, Schuller DE, Karanfilov B, Lucas JG. Update on intraoperative analysis of mandibular margins. Am J Otolaryngol. 1997;18:396.CrossRefGoogle Scholar
  67. 67.
    Mahmood S, Conway D, Ramesar KCRB. Use of intraoperative cytologic assessment of mandibular marrow scrapings to predict resection margin status in patients with squamous cell carcinoma. J Oral Maxillofac Surg. 2001;59:1138.PubMedCrossRefGoogle Scholar
  68. 68.
    Oxford LE, Ducic Y. Intraoperative evaluation of cortical bony margins with frozen-section analysis. Otolaryngol Head Neck Surg. 2016;134:138.CrossRefGoogle Scholar
  69. 69.
    Wysluch A, Stricker I, Hölzle F, Wolff K-D, Maurer P. Intraoperative evaluation of bony margins with frozen-section analysis and trephine drill extraction technique: a preliminary study. Head Neck. 2010;32:1473.PubMedCrossRefGoogle Scholar
  70. 70.
    Greenberg JS, Naggar El AK, Mo V, Roberts D, Myers JN. Disparity in pathologic and clinical lymph node staging in oral tongue carcinoma. Cancer. 2003;98:508.PubMedCrossRefGoogle Scholar
  71. 71.
    Liu M, Wang SJ, Yang X, Peng H. Diagnostic efficacy of sentinel lymph node biopsy in early oral squamous cell carcinoma: a meta-analysis of 66 studies. PLoS ONE. 2017;12:e0170322.PubMedPubMedCentralCrossRefGoogle Scholar
  72. 72.
    Lydiatt DD, Robbins KT, Byers RM, Wolf PF. Treatment of stage I and II oral tongue cancer. Head Neck. 1993;15:308.PubMedCrossRefGoogle Scholar
  73. 73.
    Yuen APW, Wei WI, Wong YM, Tang KC. Elective neck dissection versus observation in the treatment of early oral tongue carcinoma. Head Neck. 1997;19:583.PubMedCrossRefGoogle Scholar
  74. 74.
    Haddadin KJ, Soutar DS, Oliver RJ, Webster MH, Robertson AG, MacDonald DG. Improved survival for patients with clinically T1/T2, N0 tongue tumors undergoing a prophylactic neck dissection. Head Neck. 1999;21:517.PubMedCrossRefGoogle Scholar
  75. 75.
    Keski-Säntti H, Atula T, Törnwall J, Koivunen P, Mäkitie A. Elective neck treatment versus observation in patients with T1/T2 N0 squamous cell carcinoma of oral tongue. Oral Oncol. 2006;42:95.CrossRefGoogle Scholar
  76. 76.
    Capote A, Escorial V, Guerra MFM, Campo FJR, Gamallo C, Naval L. Elective neck dissection in early-stage oral squamous cell carcinoma—does it influence recurrence and survival? Head Neck. 2007;29:3.PubMedCrossRefGoogle Scholar
  77. 77.
    Huang SF, Kang C-J, Lin CY, Fan KH, Yen T-C, Wang H-M, Chen IH, Liao C-T, Cheng AJ, Chang JTC. Neck treatment of patients with early stage oral tongue cancer. Cancer. 2008;112:1066.PubMedCrossRefGoogle Scholar
  78. 78.
    Huang SF, Tung-Chieh Chang J, Liao C-T, Kang C-J, Lin C-Y, Fan KH, Wang H-M, Chen IH. The role of elective neck dissection in early stage buccal cancer. Laryngoscope. 2014;125:128.PubMedCrossRefGoogle Scholar
  79. 79.
    Vandenbrouck C, Garnier HS, Chassagne D, Saravane D, Cachin Y, Micheau C. Elective versus therapeutic radical neck dissection in epidermoid carcinoma of the oral. Cavity results of a randomized clinical trial. Cancer. 1980;46:386.PubMedCrossRefGoogle Scholar
  80. 80.
    Fakih AR, Rao RS, Borges AM, Patel AR. Elective versus therapeutic neck dissection in early carcinoma of the oral tongue. Am J Surg. 1989;158:309.PubMedCrossRefGoogle Scholar
  81. 81.
    Kligerman J, Lima RA, Soares JR, Prado L, Dias FL, Freitas EQ, Olivatto LO. Supraomohyoid neck dissection in the treatment of T1/T2 squamous cell carcinoma of oral cavity. Am J Surg. 1994;168:391.PubMedCrossRefPubMedCentralGoogle Scholar
  82. 82.
    Yuen APW, Ho CM, Chow TL, Tang LC, Cheung WY, Ng RWM, Wei WI, Kong CK, Book KS, Yuen WC, Lam AKY, Yuen NWF, Smith NJT, Chan YW, Wong BYH, Li GKH, Ho ACW, Ho WK, Wong SY, Yao TJ. Prospective randomized study of selective neck dissection versus observation for N0 neck of early tongue carcinoma. Head Neck. 2009;31:765.PubMedCrossRefGoogle Scholar
  83. 83.
    D'Cruz AK, Vaish R, Kapre N, Dandekar M, Gupta S, Hawaldar R, Agarwal JP, Pantvaidya G, Chaukar D, Deshmukh A, Kane S, Arya S, Ghosh-Laskar S, Chaturvedi P, Pai P, Nair S, Nair D, Badwe R, Head and Neck Disease Management Group. Elective versus therapeutic neck dissection in node-negative oral cancer. N Engl J Med. 2015;373:521.PubMedCrossRefGoogle Scholar
  84. 84.
    Pentenero M, Gandolfo S, Carrozzo M. Importance of tumor thickness and depth of invasion in nodal involvement and prognosis of oral squamous cell carcinoma: a review of the literature. Head Neck. 2005;27:1080.PubMedCrossRefGoogle Scholar
  85. 85.
    Brockhoff HC, Kim RY, Braun TM, Skouteris C, Helman JI, Ward BB. Correlating the depth of invasion at specific anatomic locations with the risk for regional metastatic disease to lymph nodes in the neck for oral squamous cell carcinoma. Head Neck. 2017;39:974.PubMedPubMedCentralCrossRefGoogle Scholar
  86. 86.
    Crile G. Landmark article Dec 1, 1906: excision of cancer of the head and neck. With special reference to the plan of dissection based on one hundred and thirty-two operations. JAMA. 1987;258:3286–93.PubMedCrossRefGoogle Scholar
  87. 87.
    Patel S, Sakthivel P, Singh I, Gulati A, Gupta D. Frequency of skip metastases in oral cancer: an overview. Int J Head Neck Surg. 2015;6:80.CrossRefGoogle Scholar
  88. 88.
    Cariati P, Cabello Serrano A, Fernandez Solis J, Martinez Lara I. Distribution of cervical metastasis in tongue cancer: are occult metastases predictable? A retrospective study of 117 oral tongue carcinomas. J Craniomaxillofac Surg. 2018;46:155.PubMedCrossRefGoogle Scholar
  89. 89.
    Feng Z, Li JN, Niu LX, Guo CB. Supraomohyoid neck dissection in the management of oral squamous cell carcinoma: special consideration for skip metastases at level IV or V. J Oral Maxillofac Surg. 2014;72:1203.PubMedCrossRefGoogle Scholar
  90. 90.
    Kohler HF, Cunha IWD, Kowalski LP. Impact of modified radical neck dissections on the number of retrieved nodes, recurrence and survival. Braz J Otorhinolaryngol. 2010;76:374.PubMedCrossRefGoogle Scholar
  91. 91.
    Rodrigo JP, Grilli G, Shah JP, Medina JE, Robbins KT, Takes RP, Hamoir M, Kowalski LP, Suárez C, López F, Quer M, Boedeker CC, de Bree R, Coskun H, Rinaldo A, Silver CE, Ferlito A. Selective neck dissection in surgically treated head and neck squamous cell carcinoma patients with a clinically positive neck: systematic review. Eur J Surg Oncol. 2018;44:395.PubMedCrossRefGoogle Scholar
  92. 92.
    Alkureishi LWT, Ross GL, Shoaib T, Soutar DS, Robertson AG, Thompson R, Hunter KD, Sorensen JA, Thomsen J, Krogdahl A, Alvarez J, Barbier L, Santamaria J, Poli T, Sesenna E, Kovács AF, Grünwald F, Barzan L, Sulfaro S, Alberti F. Sentinel node biopsy in head and neck squamous cell cancer: 5-year follow-up of a European Multicenter Trial. Ann Surg Oncol. 2010;17:2459.CrossRefGoogle Scholar
  93. 93.
    Ferris RL, Stefanika P, Xi L, Gooding W, Seethala RR, Godfrey TE. Rapid molecular detection of metastatic head and neck squamous cell carcinoma as an intraoperative adjunct to sentinel lymph node biopsy. Laryngoscope. 2012;122:1020.PubMedPubMedCentralCrossRefGoogle Scholar
  94. 94.
    Shaw R, Christensen A, Java K, Maddani El R, Liloglou T, Asterios T, Buchwald von C, Wessel I, Kiss K, Kjaer A, Lelkaitis G, Long A, Risk J, Robinson M. Intraoperative sentinel lymph node evaluation: implications of cytokeratin 19 expression for the adoption of OSNA in oral squamous cell carcinoma. Ann Surg Oncol. 2016;23:4042.PubMedPubMedCentralCrossRefGoogle Scholar
  95. 95.
    Boyes-Varley JG, Howes DG, Davidge-Pitts KD, Branemark I, McAlpine JA. A protocol for maxillary reconstruction following oncology resection using zygomatic implants. Int J Prosthodont. 2007;20:521.PubMedGoogle Scholar
  96. 96.
    Schmidt BL, Pogrel MA, Young CW, Sharma A. Reconstruction of extensive maxillary defects using zygomaticus implants. J Oral Maxillofac Surg. 2004;62:82.PubMedCrossRefGoogle Scholar
  97. 97.
    Zwahlen RA, Grätz KW, Oechslin CK, Studer SP. Survival rate of zygomatic implants in atrophic or partially resected maxillae prior to functional loading: a retrospective clinical report. Int J Oral Maxillofac Implants. 2006;21:413.PubMedGoogle Scholar
  98. 98.
    van Gemert JTM, van Es RJJ, Rosenberg AJWP, van der Bilt A, Koole R, Van Cann EM. Free vascularized flaps for reconstruction of the mandible: complications, success, and dental rehabilitation. J Oral Maxillofac Surg. 2012;70:1692.PubMedCrossRefGoogle Scholar
  99. 99.
    Barrowman RA, Wilson PR, Wiesenfeld D. Oral rehabilitation with dental implants after cancer treatment. Aust Dent J. 2011;56:160.PubMedCrossRefGoogle Scholar
  100. 100.
    Shugaa-Addin B, Al-Shamiri H-M, Al-Maweri S, Tarakji B. The effect of radiotherapy on survival of dental implants in head and neck cancer patients. J Clin Exp Dent. 2016;8:e194.PubMedPubMedCentralGoogle Scholar
  101. 101.
    Sclaroff A, Haughey B, Gay WD, Paniello R. Immediate mandibular reconstruction and placement of dental implants: at the time of ablative surgery. Oral Surg Oral Med Oral Pathol Oral Radiol. 1994;78:711.CrossRefGoogle Scholar
  102. 102.
    Salinas TJ, Desa VP, Katsnelson A, Miloro M. Clinical evaluation of implants in radiated fibula flaps. J Oral Maxillofac Surg. 2010;68:524.PubMedCrossRefGoogle Scholar
  103. 103.
    Jackson RS, Price DL, Arce K, Moore EJ. Evaluation of clinical outcomes of osseointegrated dental implantation of fibula free flaps for mandibular reconstruction. JAMA Facial Plast Surg. 2016;18:201.PubMedCrossRefGoogle Scholar
  104. 104.
    He Y, Zhang ZY, Zhu HG, Wu YQ, Fu HH. Double-Barrel fibula vascularized free flap with dental rehabilitation for mandibular reconstruction. J Oral Maxillofac Surg. 2011;69:2663.PubMedCrossRefGoogle Scholar
  105. 105.
    Zweifel DF, Simon C, Hoarau R, Pasche P, Broome M. Are virtual planning and guided surgery for head and neck reconstruction economically viable? J Oral Maxillofac Surg. 2015;73:170.PubMedCrossRefGoogle Scholar
  106. 106.
    Metzler P, Geiger EJ, Alcon A, Ma X, Steinbacher DM. Three-dimensional virtual surgery accuracy for free fibula mandibular reconstruction: planned versus actual results. J Oral Maxillofac Surg. 2014;72:2601.PubMedCrossRefPubMedCentralGoogle Scholar
  107. 107.
    Roser SM, Ramachandra S, Blair H, Grist W, Carlson GW, Christensen AM, Weimer KA, Steed MB. The accuracy of virtual surgical planning in free fibula mandibular reconstruction: comparison of planned and final results. J Oral Maxillofac Surg. 2010;68:2824.PubMedCrossRefGoogle Scholar
  108. 108.
    Azarmehr I, Stokbro K, Bell RB, Thygesen T. Surgical navigation: a systematic review of indications, treatments, and outcomes in oral and maxillofacial surgery. J Oral Maxillofac Surg. 2017;75:1987.PubMedCrossRefGoogle Scholar
  109. 109.
    Feichtinger M, Pau M, Zemann W, Aigner RM, Kärcher H. Intraoperative control of resection margins in advanced head and neck cancer using a 3D-navigation system based on PET/CT image fusion. J Cranio-Maxillofac Surg. 2010;38:589.CrossRefGoogle Scholar
  110. 110.
    Zhang W-B, Mao C, Liu X-J, Guo CB, Yu G-Y, Peng X. Outcomes of orbital floor reconstruction after extensive maxillectomy using the computer-assisted fabricated individual titanium mesh technique. J Oral Maxillofac Surg. 2015;73:20653.e1.CrossRefGoogle Scholar

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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Oral and Maxillofacial SurgeryUniversity of MichiganAnn ArborUSA

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