Chemoprevention in Oral Cancer

  • Jeffrey Y. Tsai
  • Jasjit K. DillonEmail author


Though many agents have been identified as potential chemoprevention strategies against oral cancer, the availability of high-quality evidence supporting their use in clinical practice remains limited. In this chapter, we discuss the concept of chemoprevention of oral cancer, review the evidence of several chemoprevention agents that have undergone clinical studies, and conclude with the challenges that prevent the use of these agents in general clinical practice. We suggest that molecular identification of markers that can be measured and can correlate with disease risk and progression may aid in selecting high-risk populations and therapeutics suitable for future clinical investigation.


Chemoprevention Oral cancer Oral premalignant lesions Oral leukoplakia Head and neck cancer N-acetylcysteine Bleomycin Polyphenols Retinoids Carotenoids COX-2 inhibitors PPAR-γ ligands Erlotinib Loss of heterozygosity Biomarkers 


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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Oral and Maxillofacial SurgeryUniversity of WashingtonSeattleUSA

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