My appointment was not only professionally rewarding, it was a personal mission because of my long connection to Europe and to Italy in particular. For three decades, my career has been linked to the European Union. My early experiences as an intern in the European Commission, a lawyer practicing EU law in an international law firm in Brussels, and a Director for European Affairs in the National Security Council under President Clinton’s administration all confirmed my belief that the US–EU partnership is critical and widely underappreciated. For six decades, US administrations of both political parties (until the Trump administration) have rightly concluded that European integration is in the political and economic interests of the United States. The Trump administration’s active efforts to undermine the EU amount to a strategic blunder.