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Sinonasal Tumor-Like Lesions

  • Alessandro FranchiEmail author
Chapter

Abstract

Sinonasal tumor-like lesions represent a heterogeneous group of non-neoplastic growths that may clinically and/or histologically mimic a tumor, thus requiring careful differential diagnosis to avoid overtreatment. Some of these lesions are common, like inflammatory polyps, while others are very rare. They occur over a wide age range, involving pediatric patients as well as adults.

Keywords

Inflammatory polyp Antrochoanal polyp Nasal glial heterotopia Nasal encephalocele Respiratory epithelial adenomatoid hamartoma Seromucinous hamartoma Chondromesenchymal hamartoma Paranasal sinus mucocele Necrotizing sialometaplasia Organized hematoma Amyloidosis Eosinophilic angiocentric fibrosis 

References

  1. 1.
    Walgama ES, Hwang PH. Aspirin-exacerbated respiratory disease. Otolaryngol Clin N Am. 2017;50:83–94.CrossRefGoogle Scholar
  2. 2.
    Hellquist H. Nasal polyps update. Histopathology. Allergy Asthma Proc. 1996;17:237–42.PubMedCrossRefPubMedCentralGoogle Scholar
  3. 3.
    Ardehali MM, Amali A, Bakhshaee M, Madani Z, Amiri M. The comparison of histopathological characteristics of polyps in asthmatic and nonasthmatic patients. Otolaryngol Head Neck Surg. 2009;140:748–51.PubMedCrossRefPubMedCentralGoogle Scholar
  4. 4.
    Compagno J, Hyams VJ, Lepore ML. Nasal polyposis with stromal atypia. Review of follow-up study of 14 cases. Arch Pathol Lab Med. 1976;100:224–6.PubMedPubMedCentralGoogle Scholar
  5. 5.
    Kindblom LG, Angerval L. Nasal polyps with atypical stromal cells: a pseudosarcomatous lesion: a light and electron microscopic and immunohistochemical investigation with implications on the type and nature of the mesenchymal cells. Acta Pathol Microbiol Immunol Scand. 1984;92:65–72.Google Scholar
  6. 6.
    Nakayama M, Wenig BM, Heffner DK. Atypical stromal cells in inflammatory nasal polyps: immunohistochemical and ultrastructural analysis in defining histogenesis. Laryngoscope. 1995;105:127–34.PubMedCrossRefGoogle Scholar
  7. 7.
    Tuziak T, Kran A, Woyke S. Edematous nasal polyp with atypical stromal cells misdiagnosed cytologically as rhabdomyosarcoma. Acta Cytol. 1995;39:521–4.PubMedPubMedCentralGoogle Scholar
  8. 8.
    Hadravsky L, Skalova A, Kacerovska D, et al. Angiomatoid change in polyps of the nasal and paranasal regions: an underrecognized and commonly misdiagnosed lesion. Report of 45 cases. Virchows Arch. 2012;460:203–9.PubMedCrossRefPubMedCentralGoogle Scholar
  9. 9.
    Heffner DK. Sinonasal angiosarcoma? Not likely (a brief description of infarcted nasal polyps). Ann Diagn Pathol. 2010;14:233–4.PubMedCrossRefPubMedCentralGoogle Scholar
  10. 10.
    Yfantis HG, Drachenberg CB, Gray W, Papadimitriou JC. Angiectatic nasal polyps that clinically simulate a malignant process. Report of 2 cases and a review of the literature. Arch Pathol Lab Med. 2000;124:406–10.Google Scholar
  11. 11.
    Sheahan P, Crotty PL, Hamilton S, Colreavy M, McShane D. Infarcted angiomatous polyps. Rhinology. 2004;262:225–30.Google Scholar
  12. 12.
    Southwood JE, Loehrl TA, Poetker DM. Advances in surgery: extended procedures for sinonasal polyp disease. Adv Otorhinolaryngol. 2016;79:148–57.PubMedPubMedCentralGoogle Scholar
  13. 13.
    Thomas AJ, Alt JA. Oral therapeutics for rhinosinusitis with nasal polyposis. Adv Otorhinolaryngol. 2016;79:138–47.PubMedPubMedCentralGoogle Scholar
  14. 14.
    Oakley GM, Harvey RJ. Topical steroids. Adv Otorhinolaryngol. 2016;79:121–30.PubMedPubMedCentralGoogle Scholar
  15. 15.
    Halderman AA, Lane AP. Immunomodulators in the treatment of nasal polyposis. Adv Otorhinolaryngol. 2016;79:103–13.PubMedPubMedCentralGoogle Scholar
  16. 16.
    Avdeeva K, Fokkens W. Precision medicine in chronic rhinosinusitis with nasal polyps. Curr Allergy Asthma Rep. 2018;18:25.PubMedPubMedCentralCrossRefGoogle Scholar
  17. 17.
    Brescia G, Zanotti C, Parrino D, Barion U, Marioni G. Nasal polyposis pathophysiology: endotype and phenotype open issues. Am J Otolaryngol. 2018;39:441–4.PubMedCrossRefPubMedCentralGoogle Scholar
  18. 18.
    Lee DH, Yoon TM, Lee JK, Lim SC. Difference of antrochoanal polyp between children and adults. Int J Pediatr Otorhinolaryngol. 2016;84:143–6.PubMedCrossRefPubMedCentralGoogle Scholar
  19. 19.
    Choudhury N, Hariri A, Saleh H, Sandison A. Diagnostic challenges of antrochoanal polyps: a review of sixty-one cases. Clin Otolaryngol. 2018;43:670–4.PubMedCrossRefPubMedCentralGoogle Scholar
  20. 20.
    Kelles M, Toplu Y, Yildirim I, Okur E. Antrochoanal polyp: clinical presentation and retrospective comparison of endoscopic sinus surgery and endoscopic sinus surgery plus mini-Caldwell surgical procedures. J Craniofac Surg. 2014;25:1779–81.PubMedCrossRefPubMedCentralGoogle Scholar
  21. 21.
    Al-Mazrou KA, Bukhari M, Al-Fayez A. Characteristics of antrochoanal polyps in the pediatric age group. Ann Thorac Med. 2009;4:133–6.PubMedPubMedCentralCrossRefGoogle Scholar
  22. 22.
    Behar PM, Muller S, Gerber ME, Todd NW. Heterotopic neuroglial tissue causing airway obstruction in the newborn. Arch Otolaryngol Head Neck Surg. 2001;127:997–1002.PubMedCrossRefPubMedCentralGoogle Scholar
  23. 23.
    Penner CR, Thompson LDR. Nasal glial heterotopia: a clinicopathologic and immunophenotypic analysis of 10 cases with a review of the literature. Ann Diagn Pathol. 2003;7:354–9.PubMedCrossRefPubMedCentralGoogle Scholar
  24. 24.
    Madjidi A, Couly G. Heterotopic neuroglial tissue of the face. Report of six cases and review of the literature. Oral Surg Oral Med Oral Pathol. 1993;76:284–8.PubMedCrossRefPubMedCentralGoogle Scholar
  25. 25.
    Adil E, Robson C, Perez-Atayde A, et al. Congenital nasal neuroglial heterotopia and encephaloceles: an update on current evaluation and management. Laryngoscope. 2016;126:2161–7.PubMedCrossRefPubMedCentralGoogle Scholar
  26. 26.
    Yeoh GP, Bale PM, de Silva M. Nasal cerebral heterotopia: the so-called nasal glioma or sequestered encephalocele and its variants. Pediatr Pathol. 1989;9:531–49.PubMedCrossRefPubMedCentralGoogle Scholar
  27. 27.
    Tetzlaff MT, Liu P, O’Malley BW Jr, LiVolsi VA, Elder D. Report of a case of sinonasal undifferentiated carcinoma arising in a background of extensive nasal gliomatosis. Head Neck. 2008;30:549–55.PubMedCrossRefPubMedCentralGoogle Scholar
  28. 28.
    Chan JK, Lau WH. Nasal astrocytoma or nasal glial heterotopia? Arch Pathol Lab Med. 1989;113:943–5.PubMedPubMedCentralGoogle Scholar
  29. 29.
    Wenig BM, Franchi A, Ro JY. Tumours of the nasal cavity, paranasal sinuses and skull base: respiratory epithelial lesions: respiratory epithelial adenomatoid hamartoma. In: El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ, editors. WHO classification of head and neck tumours. Lyon: IARC; 2017. p. 31–2.Google Scholar
  30. 30.
    Ro JY, Franchi A. Tumours of the nasal cavity, paranasal sinuses and skull base: respiratory epithelial lesions: seromucinous hamartoma. In: El-Naggar AK, JKC C, Grandis JR, Takata T, Slootweg PJ, editors. WHO classification of head and neck tumours. Lyon: IARC; 2017. p. 32.Google Scholar
  31. 31.
    Kossay M, El Zein S, Wassef M, et al. Olfactory epithelial hamartoma: a new subtype of sinonasal hamartoma. Am J Surg Pathol. 2018;42:9–17.Google Scholar
  32. 32.
    Wenig BM, Heffner DK. Respiratory epithelial adenomatoid hamartomas of the sinonasal tract and nasopharynx: a clinicopathologic study of 31 cases. Ann Otol Rhinol Laryngol. 1995;104:639–45.CrossRefGoogle Scholar
  33. 33.
    Ozolek JA, Hunt JL. Tumor suppressor gene alterations in respiratory epithelial adenomatoid hamartoma (REAH): comparison to sinonasal adenocarcinoma and inflamed sinonasal mucosa. Am J Surg Pathol. 2006;30:1576–80.PubMedCrossRefPubMedCentralGoogle Scholar
  34. 34.
    Lee JT, Garg R, Brunworth J, Keschner DB, Thompson LD. Sinonasal respiratory epithelial adenomatoid hamartomas: series of 51 cases and literature review. Am J Rhinol Allergy. 2013;27:322–8.CrossRefGoogle Scholar
  35. 35.
    Cao Z, Gu Z, Yang J, Jin M. Respiratory epithelial adenomatoid hamartoma of bilateral olfactory clefts associated with nasal polyposis: three cases report and literature review. Auris Nasus Larynx. 2010;37:352–6.CrossRefGoogle Scholar
  36. 36.
    Delbrouck C, Fernandez Aguilar S, Choufani G, Hassid S. Respiratory epithelial adenomatoid hamartoma associated with nasal polyposis. Am J Otolaryngol. 2004;25:282–4.PubMedCrossRefGoogle Scholar
  37. 37.
    Gauchotte G, Marie B, Gallet P, et al. Respiratory epithelial adenomatoid hamartoma: a poorly recognized entity with mast cell recruitment and frequently associated with nasal polyposis. Am J Surg Pathol. 2013;37:1678–85.CrossRefGoogle Scholar
  38. 38.
    Choi E, Catalano PJ, Chang KG. Chondro-osseous respiratory epithelial hamartoma of the sinonasal tract. Otolaryngol Head Neck Surg. 2006;134:168–9.PubMedCrossRefGoogle Scholar
  39. 39.
    Fang G, Wang C, Piao Y, Zhang L. Chondro-osseous respiratory epithelial adenomatoid hamartoma of the nasal cavity. Pediatr Int. 2016;58:229–31.PubMedCrossRefPubMedCentralGoogle Scholar
  40. 40.
    Jo VY, Mills SE, Cathro HP, et al. Low-grade sinonasal adenocarcinomas: the association with and distinction from respiratory epithelial adenomatoid hamartomas and other glandular lesions. Am J Surg Pathol. 2009;33:401–8.CrossRefGoogle Scholar
  41. 41.
    Hua X, Huang X, Liao Z, Xian Q, Yu L. Clinicopathological and EBV analysis of respiratory epithelial adenomatoid hamartoma. Diagn Pathol. 2014;9:70.PubMedPubMedCentralCrossRefGoogle Scholar
  42. 42.
    Ozolek JA, Barnes EL, Hunt JL. Basal/myoepithelial cells in chronic sinusitis, respiratory epithelial adenomatoid hamartoma, inverted papilloma, and intestinal-type and nonintestinal-type sinonasal adenocarcinoma: an immunohistochemical study. Arch Pathol Lab Med. 2007;131:530–7.PubMedPubMedCentralGoogle Scholar
  43. 43.
    Weinreb I. Low grade glandular lesions of the sinonasal tract: a focused review. Head Neck Pathol. 2010;4:77–83.PubMedPubMedCentralCrossRefGoogle Scholar
  44. 44.
    Weinreb I, Gnepp DR, Laver NM, et al. Seromucinous hamartomas: a clinicopathological study of a sinonasal glandular lesion lacking myoepithelial cells. Histopathology. 2009;54:205–13.PubMedCrossRefPubMedCentralGoogle Scholar
  45. 45.
    Khan RA, Chernock RD, Lewis JS Jr. Seromucinous hamartoma of the nasal cavity: a report of two cases and review of the literature. Head Neck Pathol. 2011;5:241–7.PubMedPubMedCentralCrossRefGoogle Scholar
  46. 46.
    Ambrosini-Spaltro A, Morandi L, Spagnolo DV, et al. Nasal seromucinous hamartoma (microglandular adenosis of the nose): a morphological and molecular study of five cases. Virchows Arch. 2010;457:727–34.CrossRefGoogle Scholar
  47. 47.
    McDermott MB, Ponder TB, Dehner LP. Nasal chondromesenchymal hamartoma: an upper respiratory tract analogue of the chest wall mesenchymal hamartoma. Am J Surg Pathol. 1998;22:425–33.PubMedCrossRefPubMedCentralGoogle Scholar
  48. 48.
    Mason KA, Navaratnam A, Theodorakopoulou E, Chokkalingam PG. Nasal Chondromesenchymal hamartoma (NCMH): a systematic review of the literature with a new case report. J Otolaryngol Head Neck Surg. 2015;44:28.PubMedPubMedCentralCrossRefGoogle Scholar
  49. 49.
    Stewart DR, Messinger Y, Williams GM, et al. Nasal chondromesenchymal hamartomas arise secondary to germline and somatic mutations of DICER1 in the pleuropulmonary blastoma tumor predisposition disorder. Hum Genet. 2014;133:1443–50.PubMedPubMedCentralCrossRefGoogle Scholar
  50. 50.
    Ozolek JA, Carrau R, Barnes EL, Hunt JL. Nasal chondromesenchymal hamartoma in older children and adults: series and immunohistochemical analysis. Arch Pathol Lab Med. 2005;129:1444–50.Google Scholar
  51. 51.
    Behery RE, Bedrnicek J, Lazenby A, et al. Translocation t(12;17)(q24.1;q21) as the sole anomaly in a nasal chondromesenchymal hamartoma arising in a patient with pleuropulmonary blastoma. Pediatr Dev Pathol. 2012;15:249–53.PubMedCrossRefPubMedCentralGoogle Scholar
  52. 52.
    Li Y, Yang QX, Tian XT, Li B, Li Z. Malignant transformation of nasal chondromesenchymal hamartoma in adult: a case report and review of the literature. Histol Histopathol. 2013;28:337–44.PubMedPubMedCentralGoogle Scholar
  53. 53.
    Lee TJ, Li SP, Fu CH, et al. Extensive paranasal sinus mucoceles: a 15-year review of 82 cases. Am J Otolaryngol. 2009;30:234–8.PubMedCrossRefPubMedCentralGoogle Scholar
  54. 54.
    Scangas GA, Gudis DA, Kennedy DW. The natural history and clinical characteristics of paranasal sinus mucoceles: a clinical review. Int Forum Allergy Rhinol. 2013;3:712–7.PubMedCrossRefPubMedCentralGoogle Scholar
  55. 55.
    Kim YS, Kim K, Lee JG, Yoon JH, Kim CH. Paranasal sinus mucoceles with ophthalmologic manifestations: a 17-year review of 96 cases. Am J Rhinol Allergy. 2011;25:272–5.PubMedPubMedCentralCrossRefGoogle Scholar
  56. 56.
    Devars du Mayne M, Moya-Plana A, Malinvaud D, Laccourreye O, Bonfils P. Sinus mucocele: natural history and long-term recurrence rate. Eur Ann Otorhinolaryngol Head Neck Dis. 2012;129:125–30.PubMedCrossRefPubMedCentralGoogle Scholar
  57. 57.
    Kennedy DW, Josephson JS, Zinreich SJ, et al. Endoscopic sinus surgery for mucoceles: a viable alternative. Laryngoscope. 1989;99:8858–95.Google Scholar
  58. 58.
    Loo JL, Looi AL, Seah LL. Visual outcomes in patient with paranasal mucoceles. Ophthal Plast Reconstr Surg. 2009;25:126–9.PubMedCrossRefPubMedCentralGoogle Scholar
  59. 59.
    Johnston WH. Necrotizing sialometaplasia involving the mucous glands of the nasal cavity. Hum Pathol. 1977;8:589–92.PubMedCrossRefPubMedCentralGoogle Scholar
  60. 60.
    Maisel RH, Johnston WH, Anderson HA, Cantrell RW. Necrotizing sialometaplasia involving the nasal cavity. Laryngoscope. 1977;87:429–34.PubMedCrossRefGoogle Scholar
  61. 61.
    Chen KT. Necrotizing sialometaplasia of the nasal cavity. Am J Otolaryngol. 1982;3:444–6.PubMedCrossRefPubMedCentralGoogle Scholar
  62. 62.
    Close LG, Cowan DF. Recurrent necrotizing sialometaplasia of the nasal cavity. Otolaryngol Head Neck Surg. 1985;93:422–5.PubMedCrossRefPubMedCentralGoogle Scholar
  63. 63.
    Abrams AM. Necrotizing sialometaplasia of the nasal cavity. Otolaryngol Head Neck Surg. 1986;94:416.PubMedCrossRefPubMedCentralGoogle Scholar
  64. 64.
    Granich MS, Pilch BZ. Necrotizing sialometaplasia in the setting of acute and chronic sinusitis. Laryngoscope. 1981;91:1532–5.PubMedCrossRefPubMedCentralGoogle Scholar
  65. 65.
    Franchi A, Gallo O, Santucci M. Pathologic quiz case 1. Necrotizing sialometaplasia obscuring recurrent well-differentiated squamous cell carcinoma of the maxillary sinus. Arch Otolaryngol Head Neck Surg. 1995;121:584–6.PubMedCrossRefPubMedCentralGoogle Scholar
  66. 66.
    Pang W, Hu L, Wang H, et al. Organized hematoma: an analysis of 84 cases with emphasis on difficult prediction and favorable management. Otolaryngol Head Neck Surg. 2016;154:626–33.PubMedCrossRefPubMedCentralGoogle Scholar
  67. 67.
    Choi SJ, Seo ST, Rha KS, Kim YM. Sinonasal organized hematoma: clinical features of seventeen cases and a systematic review. Laryngoscope. 2015;125:2027–33.PubMedCrossRefPubMedCentralGoogle Scholar
  68. 68.
    Kim JS, Oh JS, Kwon SH. The increasing incidence of paranasal organizing hematoma: a 20-year experience of 23 cases at a single center. Rhinology. 2016;54:176–82.PubMedCrossRefPubMedCentralGoogle Scholar
  69. 69.
    Kim EY, Kim HJ, Chung SK, et al. Sinonasal organized hematoma: CT and MR imaging findings. AJNR Am J Neuroradiol. 2008;29:1204–8.PubMedCrossRefPubMedCentralGoogle Scholar
  70. 70.
    Yokoi H, Arakawa A, Matsumoto F, Yokoi N, Ikeda K, Kohno N. Organized hematoma of the maxillary sinus: a clinicopathologic study of 5 cases. Ear Nose Throat J. 2014;93:E23–6.PubMedPubMedCentralGoogle Scholar
  71. 71.
    Omura G, Watanabe K, Fujishiro Y, Ebihara Y, Nakao K, Asakage T. Organized hematoma in the paranasal sinus and nasal cavity—imaging diagnosis and pathological findings. Auris Nasus Larynx. 2010;37:173–7.PubMedCrossRefPubMedCentralGoogle Scholar
  72. 72.
    Röcken C, Sletten K. Amyloid in surgical pathology. Virchows Arch. 2003;443:3–16.PubMedCrossRefPubMedCentralGoogle Scholar
  73. 73.
    Glenner GG. Amyloid deposits and amyloidosis. The beta-fibrilloses. N Engl J Med. 1980;302(1283–1292):1333–43.PubMedCrossRefPubMedCentralGoogle Scholar
  74. 74.
    Mufarrij AA, Busaba NY, Zaytoun GM, Gallo GR, Feiner HD. Primary localized amyloidosis of the nose and paranasal sinuses. A case report with immunohistochemical observations and a review of the literature. Am J Surg Pathol. 1990;14:379–83.PubMedCrossRefPubMedCentralGoogle Scholar
  75. 75.
    Tsikoudas A, Martin-Hirsch DP, Woodhead CJ. Primary sinonasal amyloidosis. J Laryngol Otol. 2001;115:55–6.PubMedCrossRefPubMedCentralGoogle Scholar
  76. 76.
    Prasad D, Somayaji GK, Aroor R, Abdulla MN. Primary nasal amyloidosis. Internet J Otorhinolaryngol. 2009;9:2.Google Scholar
  77. 77.
    Kumar B, Pant B, Kumar V, Negi M. Sinonasal globular amyloidosis simulating malignancy: a rare presentation. Head Neck Pathol. 2016;10:379–83.PubMedPubMedCentralCrossRefGoogle Scholar
  78. 78.
    Schönland SO, Hegenbart U, Bochtler T, et al. Immunohistochemistry in the classification of systemic forms of amyloidosis: a systematic investigation of 117 patients. Blood. 2012;119:488–93.PubMedCrossRefGoogle Scholar
  79. 79.
    Holmes DK, Panje WR. Intranasal granuloma faciale. Am J Otolaryngol. 1983;4:184–6.PubMedPubMedCentralCrossRefGoogle Scholar
  80. 80.
    Roberts PF, McCann BG. Eosinophilic angiocentric fibrosis of the upper respiratory tract: a mucosal variant of granuloma faciale? A report of three cases. Histopathology. 1985;9:1217–25.PubMedPubMedCentralCrossRefGoogle Scholar
  81. 81.
    Deshpande V, Khosroshahi A, Nielsen GP, Hamilos DL, Stone JH. Eosinophilic angiocentric fibrosis is a form of IgG4-related systemic disease. Am J Surg Pathol. 2011;35:701–6.PubMedPubMedCentralCrossRefGoogle Scholar
  82. 82.
    Heft Neal ME, Rowan NR, Willson TJ, Wang EW, Lee SE. A case report and systematic review of eosinophilic angiocentric fibrosis of the paranasal sinuses. Ann Otol Rhinol Laryngol. 2017;126:415–23.PubMedCrossRefPubMedCentralGoogle Scholar
  83. 83.
    Fang CH, Mady LJ, Mirani NM, Baredes S, Eloy JA. Sinonasal eosinophilic angiocentric fibrosis: a systematic review. Int Forum Allergy Rhinol. 2014;4:745–52.PubMedPubMedCentralCrossRefGoogle Scholar
  84. 84.
    Tabaee A, Zadeh MH, Proytcheva M, LaBruna A. Eosinophilic angiocentric fibrosis. J Laryngol Otol. 2003;117:410–3.PubMedPubMedCentralCrossRefGoogle Scholar
  85. 85.
    Thompson LD, Heffner DK. Sinonasal tract eosinophilic angiocentric fibrosis. A report of three cases. Am J Clin Pathol. 2001;115:243–8.PubMedPubMedCentralCrossRefGoogle Scholar
  86. 86.
    Jain R, Robblee JV, O’Sullivan-Mejia E, et al. Sinonasal eosinophilic angiocentric fibrosis: a report of four cases and review of literature. Head Neck Pathol. 2008;2:309–15.PubMedPubMedCentralCrossRefGoogle Scholar
  87. 87.
    Altemani AM, Pilch BZ, Sakano E, Altemani JM. Eosinophilic angiocentric fibrosis of the nasal cavity. Mod Pathol. 1997;10:391–3.PubMedPubMedCentralGoogle Scholar
  88. 88.
    Stelini RF, Moysés MD, Cintra ML, et al. Granuloma faciale and eosinophilic angiocentric fibrosis: similar entities in different anatomic sites. Appl Immunohistochem Mol Morphol. 2017;25:213–20.PubMedCrossRefPubMedCentralGoogle Scholar

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Authors and Affiliations

  1. 1.Department of Translational Research and of New Technologies in Medicine and SurgeryUniversity of PisaPisaItaly

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