Metastatic Tumors

  • Alessandro FranchiEmail author


The sinonasal tract is only rarely the site of metastatic tumors. Sinonasal metastases usually present in patients with a known history of a primary, and only occasionally they are the first manifestation of a clinically occult malignancy. The most frequent primary sites of origin of the tumors are the kidney, lung, breast, thyroid, and prostate.


Metastatic carcinoma 


  1. 1.
    Batson OV. The function of the vertebral veins and their role in the spread of metastasis. Ann Surg. 1988;112:138–49.CrossRefGoogle Scholar
  2. 2.
    Fyrmpas G, Adeniyi A, Baer S. Occult renal cell carcinoma manifesting with epistaxis in a woman: a case report. J Med Case Rep. 2011;5:79.CrossRefGoogle Scholar
  3. 3.
    Lee HM, Kang HJ, Lee SH. Metastatic renal cell carcinoma presenting as epistaxis. Eur Arch Otorhinolaryngol. 2005;262:69–71.CrossRefGoogle Scholar
  4. 4.
    Prescher A, Brors D. Metastases to the paranasal sinuses: case report and review of the literature. Laryngorhinootologie. 2001;80:583–94.CrossRefGoogle Scholar
  5. 5.
    McClatchey KD, Lloyd RV, Schaldenbrand JD. Metastatic carcinoma to the sphenoid sinus. Case report and review of the literature. Arch Otorhinolaryngol. 1985;241:219–24.CrossRefGoogle Scholar
  6. 6.
    López F, Devaney KO, Hanna EY, Rinaldo A, Ferlito A. Metastases to nasal cavity and paranasal sinuses. Head Neck. 2016;38:1847–54.CrossRefGoogle Scholar
  7. 7.
    Barnes L. Metastases to the head and neck: an overview. Head Neck Pathol. 2009;3:217–24.CrossRefGoogle Scholar
  8. 8.
    Remenschneider AK, Sadow PM, Lin DT, Gray ST. Metastatic renal cell carcinoma to the sinonasal cavity: a case series. J Neurol Surg Rep. 2013;74:67–72.CrossRefGoogle Scholar
  9. 9.
    Terada T. Renal cell carcinoma metastatic to the nasal cavity. Int J Clin Exp Pathol. 2012;5:588–91.PubMedPubMedCentralGoogle Scholar
  10. 10.
    Bastier PL, Dunion D, de Bonnecaze G, Serrano E, de Gabory L. Renal cell carcinoma metastatic to the sinonasal cavity: a review and report of 8 cases. Ear Nose Throat J. 2018;97:E6–E12.CrossRefGoogle Scholar
  11. 11.
    Altman KW, Mirza N, Philippe L. Metastatic follicular thyroid carcinoma to the paranasal sinuses: a case report and review. J Laryngol Otol. 1997;111:647–51.CrossRefGoogle Scholar
  12. 12.
    Freeman JL, Gershon A, Liavaag PG, Walfish PG. Papillary thyroid carcinoma metastasizing to the sphenoid-ethmoid sinuses and skull base. Thyroid. 1996;6:59–61.CrossRefGoogle Scholar
  13. 13.
    Altinay S, Taşkin Ü, Aydin S, Oktay MF, Özen A, Ergül N. Metastatic follicular thyroid carcinoma masquerading as olfactory neuroblastoma: with skull-base, cranium, paranasal sinus, lung, and diffuse bone metastases. J Craniofac Surg. 2015;26:e3–6.CrossRefGoogle Scholar
  14. 14.
    Conill C, Vargas M, Valduvieco I, Fernandez PL, Cardesa A, Capurro S. Metastasis to the nasal cavity from primary rectal adenocarcinoma. Clin Transl Oncol. 2009;11:117–9.CrossRefGoogle Scholar
  15. 15.
    Tanaka K. A case of metastases to the paranasal sinus from rectal mucinous adenocarcinoma. Int J Clin Oncol. 2006;11:64–5.CrossRefGoogle Scholar
  16. 16.
    Mohammed H, Sheikh R, Rahman W, Sheta S, Dogan Z. Undiagnosed hepatocellular carcinoma presenting as nasal metastases. Case Rep Otolaryngol. 2015;2015:856134.PubMedPubMedCentralGoogle Scholar
  17. 17.
    Hashim H, Rahmat K, Abdul Aziz YF, Chandran PA. Metastatic hepatocellular carcinoma presenting as a sphenoid sinus mass and meningeal carcinomatosis. Ear Nose Throat J. 2014;93:E20–3.PubMedGoogle Scholar
  18. 18.
    Lee TH, Rangan V, Khallafi H. A case of sphenoid sinus metastasis in hepatocellular carcinoma. Hepatology. 2016;63:2050–3.CrossRefGoogle Scholar
  19. 19.
    Gondim DD, Chernock R, El-Mofty S, Lewis JS Jr. The great mimicker: metastatic breast carcinoma to the head and neck with emphasis on unusual clinical and pathologic features. Head Neck Pathol. 2017;11:306–13.CrossRefGoogle Scholar
  20. 20.
    Storck K, Moh’d Hadi U, Simpson R, Ramer M, Brandwein-Gensler M. Sinonasal renal cell-like adenocarcinoma: a report on four patients. Head Neck Pathol. 2008;2:75–80.CrossRefGoogle Scholar
  21. 21.
    Kaufmann O, Dietel M. Expression of thyroid transcription factor-1 in pulmonary and extrapulmonary small cell carcinomas and other neuroendocrine carcinomas of various primary sites. Histopathology. 2000;36:415–20.CrossRefGoogle Scholar
  22. 22.
    Conill C, Vargas M, Valduvieco I, Fernández PL, Cardesa A, Capurro S. Metastasis to the nasal cavity from primary rectal adenocarcinoma. Clin Transl Oncol. 2009;11:117–9.CrossRefGoogle Scholar
  23. 23.
    Resto VA, Krane JF, Faquin WC, Lin DT. Immunohistochemical distinction of intestinal-type sinonasal adenocarcinoma from metastatic adenocarcinoma of intestinal origin. Ann Otol Rhinol Laryngol. 2006;115:59–64.CrossRefGoogle Scholar
  24. 24.
    Weng B, Wang Q, Lin S, Lu Y. Nasal cavity metastasis of breast cancer: a case report and review of the literature. Int J Clin Exp Pathol. 2014;7:7028–33.PubMedPubMedCentralGoogle Scholar
  25. 25.
    Pittoni P, Di Lascio S, Conti-Beltraminelli M, et al. Paranasal sinus metastasis of breast cancer. BMJ Case Rep. 2014;2014:bcr2014205171.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Translational Research and of New Technologies in Medicine and SurgeryUniversity of PisaPisaItaly

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