Classification of Soft Tissue Lesions and General Principles of Soft Tissue Pathology

  • Marta Sbaraglia
  • Marco Gambarotti
  • Alberto Righi
  • Angelo Paolo Dei TosEmail author


Soft tissue sarcomas are currently classified on the basis of the 2013 WHO classification of soft tissue tumors. WHO classifies the different entities on the basis of histomorphology and includes all available immunophenotypic and genetic data since the 2002 edition. This perfectly matches a diagnostic approach that integrates sequentially the microscopic features of the lesion with its immunophenotype and its genetic profile. Soft tissue sarcomas and soft tissue tumors of intermediate malignancy currently recognized by WHO classification are listed in Table 5.1.


Histopathology Histogenesis Prognosis Aggressiveness Metastasis 

Selected Bibliography

  1. Bovée JV, Hogendoorn PC. Pitfalls in pathology of soft tissue sarcomas. Cancer Treat Res. 2004;120:81–97.CrossRefGoogle Scholar
  2. Coindre JM. Immunohistochemistry in the diagnosis of soft tissue tumours. Histopathology. 2003;43(1):1–16. Review.CrossRefGoogle Scholar
  3. Deyrup AT, Weiss SW. Grading of soft tissue sarcomas: the challenge of providing precise information in an imprecise world. Histopathology. 2006;48(1):42–50. Review.CrossRefGoogle Scholar
  4. Fletcher CD. The evolving classification of soft tissue tumours: an update based on the new WHO classification. Histopathology. 2006;48(1):3–12. Review.CrossRefGoogle Scholar
  5. Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens F, editors. WHO classification of tumors of soft tissue and bone. 4th ed. Lyon: IARC; 2013.Google Scholar
  6. Fletcher CDM, Unni KK, Mertens F, editors. Pathology and genetics of tumors of soft tissue and bone. WHO classification of tumours. Lyon: IARC; 2002.Google Scholar
  7. Guillou L, Coindre JM, Bonichon F, et al. Comparative study of the National Cancer Institute and French Federation of Cancer Centers Sarcoma Group grading systems in a population of 410 adult patients with soft tissue sarcoma. J Clin Oncol. 1997;15:350–62.CrossRefGoogle Scholar
  8. Hornick JL. Novel uses of immunohistochemistry in the diagnosis and classification of soft tissue tumors. Mod Pathol. 2014;27:S47–63.CrossRefGoogle Scholar
  9. Le Loarer F, Pissaloux D, Coindre JM, Tirode F, Vince DR. Update on families of round cell sarcomas other than classical Ewing sarcomas. Surg Pathol Clin. 2017;10:587–620.CrossRefGoogle Scholar
  10. Miettinen M. From morphological to molecular diagnosis of soft tissue tumors. Adv Exp Med Biol. 2006;587:99–113.CrossRefGoogle Scholar
  11. Miettinen M. Immunohistochemistry of soft tissue tumors—review with emphasis on 10 markers. Histopathology. 2014;64:101–18.CrossRefGoogle Scholar
  12. Ordóñez JL, Osuna D, García-Domínguez DJ, et al. The clinical relevance of molecular genetics in soft tissue sarcomas. Adv Anat Pathol. 2010;17(3):162–81. Review.CrossRefGoogle Scholar
  13. Thway K. Pathology of soft tissue sarcomas. Clin Oncol. 2009;21:695–705.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Marta Sbaraglia
    • 1
  • Marco Gambarotti
    • 2
  • Alberto Righi
    • 2
  • Angelo Paolo Dei Tos
    • 1
    • 3
    Email author
  1. 1.Department of PathologyAzienda Ospedaliera di PadovaPaduaItaly
  2. 2.Department of PathologyIRCCS Istituto Ortopedico RizzoliBolognaItaly
  3. 3.Department of MedicineUniversity of Padua School of MedicinePaduaItaly

Personalised recommendations