Nerve Sheath Tumor

  • Piero PicciEmail author
  • Angelo Paolo Dei Tos


Definition: Malignant tumor that rises from a peripheral nerve, from a pre-existing benign nerve sheath tumor, in a patient with neurofibromatosis type 1, or with features of Schwann cells differentiation.


Epidemiology Imaging Histopathology Course Staging Treatment Malignant schwannoma MPNST 

Selected Bibliography

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  2. Gupta G, Mammis A, Maniker A. Malignant peripheral nerve sheath tumors. Neurosurg Clin N Am. 2008;19(4):533–43, v, Review.CrossRefGoogle Scholar
  3. Katz D, Lazar A, Lev D. Malignant peripheral nerve sheath tumour (MPNST): the clinical implications of cellular signalling pathways. Expert Rev Mol Med. 2009;11:e30, Review.CrossRefGoogle Scholar
  4. Kim DH, Murovic JA, Tiel RL, Moes G, Kline DG. A series of 397 peripheral neural sheath tumors: 30-year experience at Louisiana State University Health Sciences Center. J Neurosurg. 2005;102(2):246–55.CrossRefGoogle Scholar
  5. Ogawa BK, Skaggs DL, Kay RM. Malignant peripheral nerve sheath tumor of the lumbar spine. Am J Orthop (Belle Mead NJ). 2009;38(5):E89–92, Review.Google Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Laboratory of Experimental OncologyIRCCS Istituto Ortopedico RizzoliBolognaItaly
  2. 2.I.S.G. Italian Sarcoma GroupBolognaItaly
  3. 3.Department of PathologyAzienda Ospedaliera di PadovaPaduaItaly
  4. 4.Department of MedicineUniversity of Padua School of MedicinePaduaItaly

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