Hitching a Ride: Enhancing Nucleic Acid Delivery into Target Cells Through Nanoparticles

  • Alekhya Penumarthi
  • Preetam Basak
  • Peter SmookerEmail author
  • Ravi ShuklaEmail author
Part of the Environmental Chemistry for a Sustainable World book series (ECSW, volume 39)


Nucleic acids have gained significant interest in medicine for their therapeutic and prophylactic application. However, if delivered alone, nucleic acids are susceptible to nuclease degradation. Hence, delivering them with a suitable delivery system which can protect them could be beneficial. There is an increasing demand for novel delivery systems for nucleic acids to use them as vaccines and for gene therapy. Out of many types of delivery systems, nanoparticles are gaining importance because of their suitable properties. Hence, this chapter mainly focuses on discussing various types of nanoparticles for the delivery of nucleic acids. Recent applications of various types of nanoparticle-based viral and non-viral vectors and their advantages and disadvantages will be discussed in detail. The potential improvements which can be made to each existing nanoparticle systems are expressed. Overall this chapter is to provide an overview of importance of nanoparticles for nucleic acid delivery and is targeted towards beginners as well as advanced researchers in the field.


Nanoparticles Vaccines Gene therapy Protective immunity Nucleic acid delivery 


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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.School of ScienceRMIT UniversityBundooraAustralia
  2. 2.Bose InstituteKolkataIndia
  3. 3.NanoBiotechnology Research Laboratory, School of ScienceRMIT UniversityMelbourneAustralia

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