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CD Receptor and Targeting Strategies

  • Darsheen J. Kotak
  • Pooja A. Todke
  • Prajakta Dandekar
  • Padma V. DevarajanEmail author
Chapter
Part of the AAPS Advances in the Pharmaceutical Sciences Series book series (AAPS, volume 39)

Abstract

The clusters of differentiation (CD) are cell-surface receptors involved in cellular functions like activation, adhesion, and inhibition. These ubiquitous receptors express elevated levels of CD on cells which can serve as key marker in several cancers and infectious diseases. We emphasize on CD receptors involved in cancer, infections, and immune response. In particular, we cover the physiology and pathophysiology of the CD receptor and track the latest developments in targeted delivery of therapeutics and diagnostics mediated via CD receptor.

Keywords

Clusters of differentiation CD44 Receptor Cancer Infectious diseases Immunology 

Abbreviations

ADC

Antibody-conjugated drug

Anti-EpCAM

Human epithelial adhesion molecule

BCR

B-cell receptor

BP

Binding peptide

Ca2+

Calcium

CD

Cluster of differentiation

Ce6

Chlorine 6

CLL

Chronic lymphocytic leukemia

CmAbs

Chemotherapeutic monoclonal antibodies

CMC

Critical micelle concentration

CR3

Complement receptor

CS

Chondroitin sulfate

CTCL

Cutaneous T-cell lymphoma

CTLs

Cytotoxic T lymphocytes

DAF

Decay acceleration factor

DM4

Maytansine derivative 4

DOX

Doxorubicin

Fcgr

Fcgamma receptor

GEM

Gemcitabine

GO

Graphene oxide

GP120

Envelope glycoprotein

GPI

glycosylphosphatidylinositol

HA

Hyaluronic acid

HSA

Human serum albumin

HCCLM3

Human hepatocellular carcinoma cell line

HCT-116

Human colorectal carcinoma cell line

HepG2

Liver hepatocellular carcinoma

HIV-1

Human immunodeficiency virus type 1

HPMA

N- (2-hydroxypropyl) methacrylamide

HSV-ttk

Herpes simplex virus truncated thymidine kinase

IFN-γ

Interferon gamma

Ig

Immunoglobin

ITAMs

Immunoreceptor tyrosine-based activation motifs

Lck

Lymphocyte-specific protein tyrosine kinase

LNP

Indinavir-lipid nanoparticles

mAb

Monoclonal antibody

MDA-MB-231

M.D. Anderson and MB stands for Metastasis Breast 231

MDR

Multidrug resistance

MHC

Major histocompatibility complex

MS4A1

Membrane Spanning 4-Domains A1

MSNs

Mesoporous silica nanoparticles

MTX

Mitoxantrone

NeoR

Neomycin B-arginine conjugate

NHL

non-Hodgkin lymphoma

OPN

Osteopontin

PDAC

Pancreatic ductal adenocarcinoma

PEG-PLGA

Polyethylene glycol–poly lactic acid-co-glycolic acid

PEG–PLGA

Polyethylene glycol–poly lactic acid-co-glycolic acid

PIT

Photo-induced therapy

pMHC

Peptide-major histocompatibility complex

PNA

Peptide nucleic acids

PTKs

Protein tyrosine kinase

PTX

Paclitaxel

RFP

Red fluorescent protein

Rluc

Renilla luciferase

SCID

Significant toxicity immunodeficient

SH2

src homology 2

SLN

Solid lipid nanoparticle

TCR

T-cell receptor

TF

Triple fusion

TFIL

Tri-functional immunoliposome

Th

T helper

TNBC

Triple negative xenograft model of breast cancer

TNF-α

Tumor necrosis factor alpha

ZAP 70

Zeta-chain-associated protein kinase

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Copyright information

© American Association of Pharmaceutical Scientists 2019

Authors and Affiliations

  • Darsheen J. Kotak
    • 1
  • Pooja A. Todke
    • 1
  • Prajakta Dandekar
    • 2
  • Padma V. Devarajan
    • 2
    Email author
  1. 1.Department of Pharmaceutical Sciences &TechnologyInstitute of Chemical TechnologyMumbaiIndia
  2. 2.Department of Pharmaceutical SciencesInsitute of Chemical Technology, Deemed University, Elite Status and Centre of Excellence, Government of MaharashtraMumbaiIndia

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