Asialoglycoprotein Receptor and Targeting Strategies

  • Saugandha Das
  • Pawan Kudale
  • Prajakta Dandekar
  • Padma V. DevarajanEmail author
Part of the AAPS Advances in the Pharmaceutical Sciences Series book series (AAPS, volume 39)


The asialoglycoprotein receptor is a calcium-dependent, carbohydrate-specific, type C lectin, which is majorly present in the plasma membrane of liver cells (hepatocytes). The high liver specificity, efficient internalization rate, and ready accessibility to the vasculature present great potential of this receptor for use in site-specific targeting of nano-delivery systems for diagnostic and therapeutic applications in liver diseases with negligible nontarget toxicity. This chapter provides a detailed discussion on the receptor expression, structure, binding, ligands, and asialoglycoprotein receptor-mediated hepatocyte-targeted delivery systems. It also discusses the clinical relevance of the receptor in numerous liver afflictions along with its application in liver diagnostics.


Asialoglycoprotein ASGP-R Hepatocyte Receptor-mediated targeting Nano-delivery system 





Antibiotin antibody






Autoimmune-type chronic active hepatitis


Autoimmune hepatitis


Apolipoprotein E


Asialoglycoprotein receptor


Antisense oligonucleotides


Asialoorosomucoid AuNPs@PDA Gold nanoparticles@Polydopamine


Triiodobenzene compound


Mouse embryonic liver cells


Bovine serum albumin


Cholesten-5-yloxy-N-(4-((1-imino-2-d-thiogalactosylethyl)amino) butyl)formamide


Cyclodextrin conjugated PAMAM dendrimer


Carboxymethyl chitosan




Cationic polycarbonate diblock copolymer


Carbohydrate recognition domain


Cholesterylated thiogalactoside


Dimyristoyl diacyltrimethylammonium propane




Dioleoylphosphatidyl ethanolamine


Diethylenetriamine pentaacetic acid


Epidermal growth factor receptor-extracellular signal regulated kinases






Gadolinium diethylenetriamine pentaacetic acid


Graphene oxide


Hydrogen bond


Hepatitis B virus


Hepatocellular carcinoma


Hepatocellular carcinoma cell line


Human serum albumin


Immunoglobulins A




Kupffer cell


Lactobionic acid




Low-density lipoproteins


Liver-specific protein


Mouse hepatitis virus


Magnetic resonance imaging


N-(2hydroxypropyl) methacrylamide






Poly(vinylbenzyl-O-b-D-galactopyranosyl-D-gluconamide)-co-N-p-vinylbenzyl-6-(2-(4-dimethylamino)benzaldehydehydrazono)nicotinate-co-5,8-bis(carboxymethyl)-3-oxo-11-(2-oxo-2-((4-vinylbenzyl)amino)ethyl)-1-(4-vinylphenzyl)-2,5,8,11-tetraazatridecan-13-oic acid




Poly(β-amino ester)/poly(lactic-co-glycolic acid)




Polyethylene glycol


Poly(ethylene glycol)-poly(ε-caprolactone)




Poly-γ-glutamic acid




Polylactic acid


Poly(lactic-co-glycolic acid)




Poly (N-isopropylacrylamide)






Small interfering RNA


Single-photon emission computed tomography




Tumor necrosis factor


Tocopherol polyethylene glycol succinate


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Copyright information

© American Association of Pharmaceutical Scientists 2019

Authors and Affiliations

  • Saugandha Das
    • 1
  • Pawan Kudale
    • 1
  • Prajakta Dandekar
    • 2
  • Padma V. Devarajan
    • 2
    Email author
  1. 1.Department of Pharmaceutical Sciences & TechnologyInstitute of Chemical TechnologyMumbaiIndia
  2. 2.Department of Pharmaceutical SciencesInsitute of Chemical Technology, Deemed University, Elite Status and Centre of Excellence, Government of MaharashtraMumbaiIndia

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