Case 5: Skin Lesions of Forehead, R/O Sebaceoma

  • Dong-Lin XieEmail author
  • Tam H. Nguyen
  • Robert A. Norman
Part of the Clinical Cases in Dermatology book series (CLIDADE)


A 70-year-old man with a history of multiple skin cancers, including squamous cell carcinoma, and a history of sebaceous lesions presents for evaluation of several “moles” on his back, chest, and abdomen. These lesions were present for several years, but the patient wanted them evaluated given his history of skin cancer. He denied any bleeding, itching, or pain from the lesions. The patient denied any family history of cancer syndromes or colon cancer.


DNA mismatch repair genes, including MLH1 and MSH2 Sebaceous hyperplasia Sebaceous adenoma Sebaceoma Sebaceous carcinoma Invasive squamous cell carcinoma 

Suggested Reading

  1. Brown S, Brennan P, Rajan N. Inherited skin tumour syndromes. Clin Med (Lond). 2017;17(6):562–7.CrossRefGoogle Scholar
  2. Flux K. Sebaceous neoplasms. Surg Pathol Clin. 2017;97(8):959–61.Google Scholar
  3. Knackstedt T, Samie FH. Sebaceous carcinoma: a review of the scientific literature. Curr Treat Options in Oncol. 2017;18(8):47.CrossRefGoogle Scholar
  4. Lacobelli J, Harvey NT, Wood BA. Sebaceous lesions of the skin. Pathology. 2017;49(7):688–97.CrossRefGoogle Scholar
  5. Le S, Ansari U, Mumtaz A, Malik K, Patel P, Doyle A, Khachemoune A. Lynch syndrome and Muir-Torre syndrome: an update and review on the genetics, epidemiology, and management of two related disorders. Dermatol Online J. 2017;23:11.Google Scholar
  6. Pollinger TH, Kieliszak CR, Logemann N, Gratrix ML. Analysis of sebaceous neoplasms for DNA mismatch repair proteins in Muir-Torre syndrome. Skinmed. 2017;15(4):259–64.PubMedGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Dong-Lin Xie
    • 1
    Email author
  • Tam H. Nguyen
    • 2
  • Robert A. Norman
    • 3
    • 4
  1. 1.Ruffolo, Hooper & Associates, M.D, P.A.TampaUSA
  2. 2.DO, PGY-1 Larkin Community HospitalMiamiUSA
  3. 3.Department of DermatologyNova Southeastern UniversityTampaUSA
  4. 4.Center for Geriatric Dermatology and Neuro-DermatologyTampaUSA

Personalised recommendations