Histological Variants in Bladder Cancer—Sqaumous Cell Carcinoma and Squamous Differentiation

  • Sanchia S. GoonewardeneEmail author
  • Raj Persad
  • Hanif Motiwala
  • David Albala


Bladder squamous cell carcinoma, squamous metaplasia, and transitional cell carcinoma with squamous differentiation are rare findings (Rausch et al. in Urol Oncol. 32(1):32.e11–6, 2014). A common risk factor is chronic bladder irritation and inflammation (Rausch et al. in Urol Oncol. 32(1):32.e11–6, 2014). This chapter covers diagnosis and management.


  1. Abdollah F, Sun M, Jeldres C, Schmitges J, Thuret R, Djahangirian O, Tian Z, Shariat SF, Perrotte P, Montorsi F, Karakiewicz PI. Survival after radical cystectomy of non-bilharzial squamous cell carcinoma vs urothelial carcinoma: a competing-risks analysis. BJU Int. 2012;109(4):564–9.CrossRefGoogle Scholar
  2. Porten SP, Willis D, Kamat AM. Variant histology: role in management and prognosis of nonmuscle invasive bladder cancer. Curr Opin Urol. 2014;24(5):517–23.CrossRefGoogle Scholar
  3. Raman JD, Jafri SM. Surgical management of bladder urothelial carcinoma with squamous differentiation. Urol Oncol. 2015;33(10):429–33.CrossRefGoogle Scholar
  4. Rausch S, Lotan Y, Youssef RF. Squamous cell carcinogenesis and squamous cell carcinoma of the urinary bladder: a contemporary review with focus on nonbilharzial squamous cell carcinoma. Urol Oncol. 2014;32(1):32.e11–6.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Sanchia S. Goonewardene
    • 1
    Email author
  • Raj Persad
    • 2
  • Hanif Motiwala
    • 3
  • David Albala
    • 4
  1. 1.East of England DeaneryNorfolk and Norwich University HospitalNorwichUK
  2. 2.North Bristol NHS TrustBristolUK
  3. 3.Southend University HospitalWestcliff-on-SeaUK
  4. 4.Boston UniversityBostonUSA

Personalised recommendations