Nodal Malignant Lymphoma (With Comments on Extranodal Malignant Lymphoma and Metastatic Cancer)
- 19 Downloads
Nodal Malignant Lymphoma (with Comments on Extranodal Malignant Lymphoma and Metastatic Cancer): this chapter outlines the incidence, risk factors, clinical presentation, investigations, treatments and prognosis of cancer relating to lymph nodes. These features are correlated with the core data that are required to make corresponding histopathology reports of a consistently high quality, available in an appropriate timeframe, and clinically relevant to patient management and prognosis. Summary details of the common cancers given at this site include: gross description, histological types, tumour grade/differentiation, extent of local tumour spread, lymphovascular involvement, and the status of excision margins. Current WHO Classifications of Malignant Tumours and relevant staging are referenced. Notes are provided on other associated pathology, contemporary use of immunohistochemistry, updates on the role of evolving molecular tests, and the use of these ancillary techniques as biomarkers in diagnosis, and prediction of prognosis and treatment response.
KeywordsLymphoma Ann Arbor staging
- Attygalle AD, Cabeçadas J, Gaulard P, et al. Peripheral T-cell and NK-cell lymphomas and their mimics; taking a step forward—report on the lymphoma workshop of the XVIth meeting of the European Association for Haematopathology and the Society for Hematopathology. Histopathology. 2014;64:171–99.CrossRefGoogle Scholar
- Brunning RD, Arber DA. Bone marrow. Chapter 23. In: Rosai J, editor. Rosai and Ackerman’s surgical pathology. 10th ed. Amsterdam: Elsevier; 2011.Google Scholar
- Chan JKC. Tumours of the lymphoreticular system, including spleen and thymus. In: Fletcher CDM, editor. Diagnostic histopathology of tumours, vol. 2. 3rd ed. London: Harcourt; 2007. p. 1139–310.Google Scholar
- Rosai J. Lymph nodes, spleen. Chapter 22. In: Goldblum J, Lamps L, McKenney J, Myers J, editors. Rosai and Ackerman’s surgical pathology. 11th ed. Amsterdam: Elsevier; 2017.Google Scholar
- O’Malley DP, George TI, Orazi A, editors. Benign and reactive conditions of lymph node and spleen. Washington DC: ARP Press; 2009.Google Scholar
- Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J. WHO classification of tumours of haemopoietic and lymphoid tissues. 4th ed. Lyon: IARC Press; 2017.Google Scholar
- The National Cancer Action Team and The Royal College of Pathologists. Additional best practice commissioning guidance for developing haematology diagnostic services. (in line with the NICE improving outcomes guidance for haemato-oncology). http://www.rcpath.org/publications-media/publications
- The Royal College of Pathologists. Standards for specialist laboratory integration and dataset for the histopathological reporting of lymphomas. 2015. https://www.rcpath.org/uploads/assets/uploaded/dc15eefa-4b49-461d-a292fa44a6541e03.pdf.
- The Royal College of Pathologists. Standards and datasets for reporting cancers. Dataset for histopathological reporting of cancer of unknown primary (CUP) or malignancy of unknown primary origin (UO). 2018. www.rcpath.org/uploads/assets/uploaded/d060a31a-b4b5-4e05-8396b65125b7fa87.pdf.
- Warnke RA, Weiss LM, Chan JKC, Cleary ML, Dorfman RF. Tumors of the lymph nodes and spleen. Atlas of tumor pathology, vol. 3. Washington, DC: AFIP; 1995.Google Scholar