Penile Carcinoma

  • Declan O’RourkeEmail author


Penile Carcinoma: this chapter outlines the incidence, risk factors, clinical presentation, investigations, treatments and prognosis of cancer at this anatomical site. These features are correlated with the core data that are required to make corresponding histopathology reports of a consistently high quality, available in an appropriate timeframe, and clinically relevant to patient management and prognosis. Summary details of the common cancers given at this site include: gross description, histological types, tumour grade/differentiation, extent of local tumour spread, lymphovascular invasion, lymph node involvement, and the status of excision margins. Current WHO Classifications of Malignant Tumours and TNM8 are referenced. Notes are provided on other associated pathology, contemporary use of immunohistochemistry, updates on the role of evolving molecular tests, and the use of these ancillary techniques as biomarkers in diagnosis, and prediction of prognosis and treatment response. A summary is given of the more common non-carcinoma malignancies that are encountered at this site in diagnostic practice.


Squamous cell carcinoma HPV Penile intraepithelial neoplasia TNM8 Lichen sclerosus 


  1. Allen DC, Cameron RI. Histopathology specimens: clinical, pathological and laboratory aspects. 3rd ed. London: Springer; 2017.CrossRefGoogle Scholar
  2. Arya M, et al. Long-term trends in incidence, survival and mortality of primary penile cancer in England. Cancer Causes Control. 2013;24:2169.CrossRefGoogle Scholar
  3. Chaux A, Cubilla AL. Diagnostic problems in precancerous lesions and invasive carcinomas of the penis. Semin Diagn Pathol. 2012a;29:72–82.CrossRefGoogle Scholar
  4. Chaux A, Cubilla AL. The role of human papillomavirus infection in the pathogenesis of penile squamous cell carcinoma. Semin Diagn Pathol. 2012b;29:67–71.CrossRefGoogle Scholar
  5. Chaux A, Pfannl R, Rodríguez IM, et al. Distinctive immunohistochemical profile of penile intraepithelial lesions: a study of 74 cases. Am J Surg Pathol. 2011;35:553–62.CrossRefGoogle Scholar
  6. Chaux A, Velazquez EF, Amin A, et al. Distribution and characterization of subtypes of penile intraepithelial neoplasia and their association with invasive carcinomas: a pathological study of 139 lesions in 121 patients. Hum Pathol. 2012a;43:1020–7.CrossRefGoogle Scholar
  7. Chaux A, Velazquez EF, Barreto JE, Ayala E, Cubilla AL. New pathologic entities in penile carcinomas: an update of the 2004 World Health Organization classification. Semin Diagn Pathol. 2012b;29:59–66.CrossRefGoogle Scholar
  8. Corbishley CM, Rajab RM, Watkin NA. Clinicopathological features of carcinoma of the distal penile urethra. Semin Diagn Pathol. 2015a;32:238–44.CrossRefGoogle Scholar
  9. Corbishley CM, Tinwell B, Kaul A, Ayres B, Watkin NA. Glans resurfacing for precancerous and superficially invasive carcinomas of the glans penis. Pathological specimen handling and reporting. Semin Diagn Pathol. 2015b;32:232–7.CrossRefGoogle Scholar
  10. Cubilla AL. The role of pathologic prognostic factors in squamous cell carcinoma of the penis. World J Urol. 2009;27:169–77.CrossRefGoogle Scholar
  11. Epstein JI, Cubilla AL, Humphrey PA. Tumours of the prostate gland, seminal vesicles, penis and scrotum. Washington, DC: Armed Forces Institute of Pathology; 2011. p. 405–611.Google Scholar
  12. Hakenberg OW, Comperat EM, Minhas S, Necchi A, Protzel C, Watkin N. Guidelines on penile cancer, 2014 update. Eur Urol. 2015;67:142–50.CrossRefGoogle Scholar
  13. Horenblas S. Sentinel lymph node biopsy in penile carcinoma. Semin Diagn Pathol. 2012;29:90–5.CrossRefGoogle Scholar
  14. Kulkarni M, Yap T, Bleicher G, Minhas S. Organ-sparing treatment for penile cancer. Eur Urol Suppl. 2018;17:146–53.CrossRefGoogle Scholar
  15. Moch H, Cubilla AL, Humphrey PA, Reuter VE, Ulbright TM. The 2016 WHO classification of tumours of the urinary system and male genital organs-part a: renal, penile, and testicular tumours. Eur Urol. 2016;70:93–105.CrossRefGoogle Scholar
  16. Hakenberg OW, Drager D, Erbersdobler A. Pathology, molecular biology, and prognosis of penile squamous cell carcinoma: what can we learn from the specimen? Eur Urol Suppl. 2018;17:138–45.CrossRefGoogle Scholar
  17. Oxley JD, Corbishley C, Down L, Watkin N, Dickerson D, Wong NACS. Clinicopathological and molecular study of penile melanoma. J Clin Pathol. 2012;65:228–31.CrossRefGoogle Scholar
  18. Brierley JD, Gospodarowicz MK, Wittekind C, editors. TNM classification of malignant tumours. 8th ed. Oxford, UK: Wiley-Blackwell; 2017.Google Scholar
  19. Siegal R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA Cancer J Clin. 2014;64:9–29.CrossRefGoogle Scholar
  20. Tang V, Clarke L, Gall Z, Shanks JH, Nonaka D, Parr NJ, et al. Should centralized histopathological review in penile cancer be the global standard? BJU Int. 2014;114:340–3.PubMedGoogle Scholar
  21. The Royal College of Pathologists. Standards and datasets for reporting cancers Dataset for penile and distal urethral cancer histopathology reports. 2015.
  22. Hermanek P, Hutter RVP, Sobin LH, Wagner G, Wittekind C. TNM atlas: illustrated guide to the TNM/pTNM classification of malignant tumours. 8th ed. Berlin/Heidelberg: Springer; 2016.Google Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Institute of PathologyRoyal Victoria HospitalBelfastUK

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