• Giorgio TregliaEmail author
  • Barbara Muoio
  • Luca Giovanella


18F-FET is a radiolabelled amino acid that may be used as PET radiopharmaceutical in neuro-oncology. 18F-FET PET has been demonstrated to be useful in the differential diagnosis between brain tumours and non-neoplastic lesions and between low-grade and high-grade gliomas. Integration of 18F-FET PET into surgical planning allows better delineation of the extent of resection beyond margins visible with standard MRI. For biopsy planning, 18F-FET PET is particularly useful in identifying malignant foci within non-contrast-enhancing gliomas. 18F-FET PET may also improve the radiation therapy planning in patients with gliomas. This metabolic imaging method may be useful to evaluate treatment response in patients with gliomas and it improves the differential diagnosis between brain tumours recurrence and post-treatment changes. Furthermore, 18F-FET PET may provide useful prognostic information in high-grade gliomas.

Overall, based on literature data 18F-FET PET may provide additional diagnostic information compared to standard MRI in neuro-oncology.


18F-FET Fluoroethyltyrosine PET Brain tumours Glioma Neuro-oncology 



Fluorine-18 fluorodeoxyglucose


Fluorine-18 fluorodihydroxyphenylalanine


Fluorine-18 fluoroethyltyrosine


Fluorine-18 fluorothymidine


Computed tomography


European Association for Neuro-Oncology


Lesion-to-background ratio




Magnetic resonance imaging


Positron emission tomography


Response Assessment in Neuro-Oncology (RANO)





Conflicts of Interest: The authors declare that they have no conflicts of interest.


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Giorgio Treglia
    • 1
    • 2
    • 3
    Email author
  • Barbara Muoio
    • 4
  • Luca Giovanella
    • 1
  1. 1.Imaging Institute of Southern SwitzerlandEnte Ospedaliero CantonaleBellinzona and LuganoSwitzerland
  2. 2.Health Technology Assessment Unit, General DirectorateEnte Ospedaliero CantonaleBellinzonaSwitzerland
  3. 3.Department of Nuclear Medicine and Molecular ImagingUniversity Hospital of Lausanne and University of LausanneLausanneSwitzerland
  4. 4.Oncology Institute of Southern Switzerland, Ente Ospedaliero CantonaleBellinzonaSwitzerland

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