Medical Treatment of GERD

  • Charles Muller
  • Natalie Tapaskar
  • Robert T. KavittEmail author


Medical therapy for gastroesophageal reflux disease (GERD) may be approached in two ways: directly applied to correct the underlying mechanisms involved in disease pathogenesis or alternatively applied to symptom severity in a “step-up” or “step-down” fashion. Mechanistic approaches to therapy can further be subdivided into directing therapy at decreasing the frequency of transient lower esophageal sphincter relaxation to minimize esophageal exposure to gastric acid or more commonly neutralizing or suppressing gastric acidity, thereby rendering refluxed materials less caustic to esophageal mucosa. Pharmacologic agents for patients with persistent symptoms despite lifestyle interventions include nonabsorbable agents, antisecretory agents, prokinetic agents, and inhibitors of transient lower esophageal sphincter relaxations (TLESRs).


Gastroesophageal reflux disease GERD PPI (proton pump inhibitor) Acid reflux Antacids Histamine-2-receptor antagonists GERD in pregnancy 


Conflicts of Interest

The authors have no conflicts of interest to declare.


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Charles Muller
    • 1
  • Natalie Tapaskar
    • 2
  • Robert T. Kavitt
    • 3
    • 4
    Email author
  1. 1.Department of Medicine, Section of Gastroenterology, Hepatology, and NutritionUniversity of ChicagoChicagoUSA
  2. 2.Department of MedicineUniversity of ChicagoChicagoUSA
  3. 3.Center for Esophageal Diseases, Department of Medicine, Section of Gastroenterology, Hepatology, and NutritionUniversity of ChicagoChicagoUSA
  4. 4.University of Chicago MedicineChicagoUSA

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