Historical Notes on the Surgical Treatment of GERD

  • Vera Lucia Ângelo Andrade
  • Fernando A. M. HerbellaEmail author


Gastroesophageal reflux disease (GERD) is a highly prevalent disease with symptoms that have been described for centuries. The surgical therapy, however, has a brief history starting at the beginning of the twentieth century. The delay in the development of antireflux operations can be credited to the lack of knowledge of the pathophysiology of GERD and the limitation of diagnostic methods. Nissen should be remembered as a pioneer in the development of antireflux surgery. However, the procedure that Nissen first described in 1956 underwent several modifications over time, so that the term “Nissen Fundoplication” may have different meanings to different surgeons. The historical evolution of fundoplication can be demonstrated through a timeline that passes through the original Nissen technique and its most relevant modifications, such as those proposed by Rosseti, Toupet, Donahue, and DeMeester, which aimed to improve GERD symptoms and minimize side effects. The historical understanding of this evolution should stimulate further technical improvements to benefit GERD patients.


Gastroesophageal reflux disease Nissen fundoplication Toupet fundoplication Dor fundoplication Floppy fundoplication Guarner fundoplication 


Conflicts of Interest

The authors have no conflicts of interest to declare.


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Vera Lucia Ângelo Andrade
    • 1
  • Fernando A. M. Herbella
    • 2
    Email author
  1. 1.Department of Pathology, Faculdade de Medicina da UninCorUniversidade Vale do Rio VerdeBelo HorizonteBrazil
  2. 2.Department of SurgeryEscola Paulista de Medicina, Federal University of Sao PauloSao PauloBrazil

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