Intrathecal Drug Delivery

  • Saiyun Hou
  • Salahadin AbdiEmail author


This chapter is to introduce the use of an intrathecal drug delivery system for the management of refractory chronic cancer or noncancer pain. The chapter begins with an overview as to how intrathecal therapy can be a useful modality to modulate spinal transmission of pain (nociceptive) signals, followed by historical perspectives, indications, contraindications of intrathecal therapy, and current guidelines from the Polyanalgesic Consensus Conference (PACC). The chapter introduces the relevant surgical techniques, complications, and troubleshooting and concludes with a summary of the use of intrathecal therapy and future advancements in developing new pump technology, catheter materials, and intrathecal drugs for the treatment of severe chronic pain.


Intrathecal drug delivery Intrathecal pain pump Chronic pain Cancer pain Noncancer pain Neuromodulation 


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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Pain MedicineThe University of Texas MD Anderson Cancer CenterHoustonUSA

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