Management of Acute, Severe, and Life-Threatening Exacerbations

  • Angela Marko
  • Elizabeth Pace
  • Kristie R. RossEmail author


Severe acute exacerbations are common in children with asthma. They are troublesome to patients and caregivers, can result in long-term morbidity, and are costly. While severe (requiring emergency room and hospital-based care) and life-threatening (with impending or established respiratory failure requiring intensive care unit-based care) exacerbations can occur in any child with asthma, children with more severe chronic asthma and those with a recent exacerbation are at highest risk. Systemic corticosteroids and beta2-agonists are the primary treatments used, with many adjunctive therapies available although less well studied.


Life-threating exacerbation Severe exacerbation Pediatric asthma 


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Angela Marko
    • 1
  • Elizabeth Pace
    • 2
  • Kristie R. Ross
    • 1
    Email author
  1. 1.Division of Pediatric Pulmonology, Allergy/Immunology, and Sleep MedicineUH Rainbow Babies and Children’s Hospital, Case Western Reserve UniversityClevelandUSA
  2. 2.Division of Pediatric Critical Care UH Rainbow Babies and Children’s Hospital, Case Western Reserve UniversityClevelandUSA

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