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Glioma Imaging pp 139-159 | Cite as

Imaging Markers of Lower-Grade Diffuse Glioma

  • Melanie A. Morrison
  • Adam D. WaldmanEmail author
Chapter

Abstract

This chapter provides an overview of the current status of molecular and imaging markers in lower-grade glioma (LGG; diffuse glioma WHO grade II) management. We first review molecular markers acknowledged under the recent World Health Organization (WHO) diagnostic criteria that have enabled prognostic stratification of gliomas into distinct molecular subtypes. A discussion of current imaging markers follows, including surrogate markers of histological tumour grade and molecular features, and characteristics that aid in early detection of malignant transformation (MT).

Keywords

Low-grade glioma Molecular biomarkers Quantitative imaging biomarkers Disease stratification Tissue characterisation Malignant transformation Early detection 

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Radiology and Biomedical Imaging at UCSFSan FranciscoUSA
  2. 2.Centre for Clinical Brain Sciences, University of EdinburghEdinburghScotland, UK
  3. 3.Department of MedicineImperial College LondonLondonUK

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