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Adjuvant Pharmaceutical Therapy for Perioperative Use in Bariatric Surgery

  • John M. Morton
  • Saber Ghiassi
  • Geoffrey S. Nadzam
Chapter

Abstract

Bariatric surgery has been demonstrated as a very safe and effective therapy for patients with obesity. Considerable understanding of obesity as a disease has also occurred, indicating a variable response to any form of intervention. Accompanying this understanding of obesity as a disease are multiple anti-obesity medications, which can serve as primary and adjuvant therapy for patients with obesity. This chapter describes indications and appropriateness in the use of anti-obesity medications in the bariatric surgery population.

Keywords

Bariatric Surgery Sleeve gastrectomy Gastric bypass Adjuvant Medications Preoperative Postoperative Weight loss Weight gain 

References

  1. 1.
    Buchwald H, Avidor Y, Braunwald E, et al. Bariatric surgery: a systematic review and meta-analysis. JAMA. 2004;292(14):1724–37.CrossRefGoogle Scholar
  2. 2.
    Adams TD, Davidson LE, Hunt SC. Weight and metabolic outcomes 12 years after gastric bypass. N Engl J Med. 2018;378(1):93–6.CrossRefGoogle Scholar
  3. 3.
    Morton JM, Ponce J, Malangone-Monaco E, Nguyen N. Association of bariatric surgery and national medication utilization. J Am Coll Surg. 2018. pii: S1072-7515(18)32158-6.Google Scholar
  4. 4.
    Schauer, et al. Bariatric surgery versus intensive medical therapy for diabetes—5-year outcomes. February 16, 2017. N Engl J Med. 2017;376:641–51.CrossRefGoogle Scholar
  5. 5.
    Scott JD, Morton JM. Advocacy for bariatric and metabolic surgery. Curr Surg Rep. 2018;6:17.CrossRefGoogle Scholar
  6. 6.
  7. 7.
    Azagury D, Mokhtari TE, Garcia L, Rosas US, Garg T, Rivas H, Morton J. Surgery. Heterogeneity of weight loss after gastric bypass, sleeve gastrectomy, and adjustable gastric banding. 2018. pii: S0039-6060(18)30559-2.Google Scholar
  8. 8.
    Varban O, et al. Factors associated with achieving a BMI< 30. JAMA Surg. 2017;152(11):1058–64.CrossRefGoogle Scholar
  9. 9.
    Bessler M, Daud A, DiGiorgi MF, Schrope BA, Inabnet WB, Davis DG. Frequency distribution of weight loss percentage after gastric bypass and adjustable gastric banding. Surg Obes Relat Dis. 2008;4:486–91.CrossRefGoogle Scholar
  10. 10.
    Brethauer SA, et al. Systematic review on reoperative bariatric surgery: American Society for Metabolic and Bariatric Surgery Revision Task Force. Surg Obes Relat Dis. 2014. pii: S1550-7289(14)00060-4.Google Scholar
  11. 11.
    Reinhold RB. Critical analysis of long term weight loss following gastric bypass. Surg Gynecol Obstet. 1982;155:385–94.PubMedGoogle Scholar
  12. 12.
    D’Agostino RB. Goodness-of-fit-techniques. Boca Raton: CRC Press; 1986.Google Scholar
  13. 13.
    Adams ST, Salhab M, Hussain ZI, et al. Roux-en-Y gastric bypass for morbid obesity: what are the preoperative predictors of weight loss? Postgrad Med J. 2013;89(1053):411–6.  https://doi.org/10.1136/postgradmedj-2012-131310; quiz 415, 416. Epub 2013 Mar 7.CrossRefPubMedGoogle Scholar
  14. 14.
    Bekheit M, Katri K, Ashour MH, et al. Gender influence on long-term weight loss after three bariatric procedures: gastric banding is less effective in males in a retrospective analysis. Surg Endosc. 2014;28(8):2406–11.  https://doi.org/10.1007/s00464-014-3489-7. Epub 2014 Mar 20.CrossRefPubMedGoogle Scholar
  15. 15.
    Livhits M, Mercado C, Yermilov I, et al. Preoperative predictors of weight loss following bariatric surgery: systematic review. Obes Surg. 2012;22(1):70–89.  https://doi.org/10.1007/s11695-011-0472-4. Review.CrossRefPubMedGoogle Scholar
  16. 16.
    Palmisano S, Silvestri M, Giuricin M, et al. Preoperative predictive factors of successful weight loss and Glycaemic control 1 year after gastric bypass for morbid obesity. Obes Surg. 2015;25(11):2040–6.CrossRefGoogle Scholar
  17. 17.
    Robinson AH, Adler S, Stevens HB, et al. What variables are associated with successful weight loss outcomes for bariatric surgery after 1 year? Surg Obes Relat Dis. 2014;10(4):697–704.CrossRefGoogle Scholar
  18. 18.
    Hutcheon DA, Hale AL, Ewing JA, et al. Short-term preoperative weight loss and postoperative outcomes in bariatric surgery. J Am Coll Surg. 2018;226(4):514–24.CrossRefGoogle Scholar
  19. 19.
    Livhits M, Mercado C, Yermilov I, et al. Does weight loss immediately before bariatric surgery improve outcomes: a systematic review. Surg Obes Relat Dis. 2009;5(6):713–21.CrossRefGoogle Scholar
  20. 20.
    Krimpuri RD, Yokley JM, Seeholzer EL, et al. Qualifying for bariatric surgery: is preoperative weight loss a reliable predictor of postoperative weight loss? Surg Obes Relat Dis. 2018;14(1):60–4.CrossRefGoogle Scholar
  21. 21.
    Pekkarinen T, Mustonen H, Sane T, et al. Long-term effect of gastric bypass and sleeve gastrectomy on severe obesity: do preoperative weight loss and binge eating behavior predict the outcome of bariatric surgery? Obes Surg. 2016;26(9):2161–7.CrossRefGoogle Scholar
  22. 22.
    Cassie S, Menezes C, Birch DW, et al. Effect of preoperative weight loss in bariatric surgical patients: a systematic review. Surg Obes Relat Dis. 2011;7(6):760–7.CrossRefGoogle Scholar
  23. 23.
    Gerber P, Anderin C, Thorell A. Weight loss prior to bariatric surgery: an updated review of the literature. Scand J Surg. 2015;104(1):33–9.CrossRefGoogle Scholar
  24. 24.
    Benotti PN, Still CD, Craig Wood G, et al. Preoperative weight loss before bariatric surgery. Arch Surg. 2009;144(12):1150–5.CrossRefGoogle Scholar
  25. 25.
    Alami RS, Morton JM, Schuster R, et al. Is there a benefit to preoperative weight loss in gastric bypass patients? A prospective randomized trial. Surg Obes Relat Dis. 2007;3(2):141–5; discussion 145–6. Epub 2007 Feb 27.CrossRefGoogle Scholar
  26. 26.
  27. 27.
    Sudan R, Nguyen NT, Hutter MM, Brethauer SA, Ponce J, Morton JM. Morbidity, mortality, and weight loss outcomes after reoperative bariatric surgery in the USA. J Gastrointest Surg. 2015;19(1):171–8.CrossRefGoogle Scholar
  28. 28.
  29. 29.
  30. 30.
  31. 31.
  32. 32.
    FDA Guidance for Industry, Developing Products for Weight Management https://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm071612.pdf. Accessed 4/10/2019.
  33. 33.
  34. 34.
  35. 35.
  36. 36.
  37. 37.
  38. 38.
  39. 39.
  40. 40.
    https://www.abom.org. Accessed 4/10/2019.
  41. 41.
    Jester L, et al. Obesity medications. Obes Surg. 1996;6:412–5.Google Scholar
  42. 42.
    Schwartz J, et al. Obesity medications. Obes Surg. 2016;26:452–8.Google Scholar
  43. 43.
    Hanipah, et al. Obesity medications. SOARD. 2018;14:93–8.Google Scholar
  44. 44.
    Morton J, et al. Lomaira vs. placebo: an RCT for preoperative bariatric surgery, Obesity Week 2018, Nashville.Google Scholar
  45. 45.
    http://www.mbsaqip.org/. Accessed 4/10/2019.

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • John M. Morton
    • 1
  • Saber Ghiassi
    • 2
  • Geoffrey S. Nadzam
    • 3
  1. 1.Bariatric and Minimally Invasive Surgery DivisionYale School of MedicineNew HavenUSA
  2. 2.Department of SurgeryYale School of MedicineFairfieldUSA
  3. 3.Department of SurgeryYale School of MedicineNew HavenUSA

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