• Lenar YessayanEmail author
  • Ryan E. Krahn


Abnormalities of the plasma sodium concentration are the most common electrolyte disorders encountered in clinical medicine. Appropriate therapy for hyponatremia should keep the patient safe from deleterious complications of hyponatremia while avoiding correction rates that risk brain injury. Skilled management of hyponatremia requires an understanding of the physiologic processes which regulate plasma sodium, the pathologic settings in which it occurs, and the ability to account for factors that affect plasma sodium concentration.


Hyponatremia Osmotic demyelination syndrome Brain edema Brain herniation 


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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Division of Nephrology, Department of Internal MedicineUniversity of Michigan, 3914 Taubman CenterAnn ArborUSA

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