The Post-Intensive Care Syndrome

  • Jason H. Maley
  • Mark E. MikkelsenEmail author


Post-intensive care syndrome (PICS) is defined as newly recognized or worsening impairment in one or more of the following domains after critical illness: cognitive function, mental health, and physical function. These impairments frequently persist and can impact health-related quality of life after critical illness. In this chapter, we provide an illustrative case, and then we detail the clinical manifestations, diagnosis, and prevention and management strategies related to PICS. Last, we explore controversial aspects of PICS management that require further study.


Critical illness Cognitive impairment Mental health Physical impairment Post-intensive care syndrome 


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Pulmonary and Critical Care Medicine, Massachusetts General HospitalBeth Israel Deaconess Medical Center, Harvard Medical SchoolBostonUSA
  2. 2.Division of Pulmonary, Allergy, and Critical Care, Department of MedicinePerelman School of Medicine at the University of PennsylvaniaPhiladelphiaUSA

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