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Eosinophilic Esophagitis

  • Betty H. Li
  • Nina Gupta
  • Robert T. KavittEmail author
Chapter

Abstract

Eosinophilic esophagitis (EoE) is a chronic allergen-driven immune-mediated condition that is increasingly recognized as a major cause of upper GI morbidity. The understanding of genetic, environmental, and cellular factors involved in the pathogenesis of the disease has evolved considerably in the last two decades. This chapter aims to provide an evidence-based overview of the epidemiology, pathophysiology, diagnosis, and treatment of eosinophilic esophagitis. This chapter will provide an up-to-date review, with revised criteria for diagnosis of EoE discussed along with controversies surrounding responsiveness to proton pump inhibitors and their role in current management. This chapter will also examine the data for topical glucocorticoids and food elimination diets as first-line treatments along with new targeted biologic therapies under investigation. Endoscopic evaluation with biopsy remains the only accurate test for diagnosis and monitoring of EoE and the common features will be summarized. Furthermore, this chapter will review the current literature regarding ongoing efforts to develop reliable and minimally invasive techniques for the assessment of disease activity (such as mucosal impedance, functional lumen imaging, and esophageal string testing).

Keywords

Eosinophilic esophagitis EoE Dysphagia 

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of MedicineUniversity of ChicagoChicagoUSA
  2. 2.Section of Gastroenterology, Hepatology, and NutritionUniversity of ChicagoChicagoUSA
  3. 3.Center for Esophageal Diseases, Section of Gastroenterology, Hepatology, and NutritionUniversity of ChicagoChicagoUSA

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