Clinical Applications of Circulating Tumor Cells in Breast Cancer

  • Erin F. Cobain
  • Costanza Paoletti
  • Jeffrey B. Smerage
  • Daniel F. HayesEmail author
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 215)


The development of metastatic disease accounts for the vast majority of cancer-related deaths in solid tumor malignancies. Distant metastases primarily develop as a result of tumor cell dissemination through the circulatory system.


Circulating tumor cell (CTC) Breast cancer Liquid biopsy Tumor marker 


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Erin F. Cobain
    • 1
  • Costanza Paoletti
    • 1
  • Jeffrey B. Smerage
    • 1
  • Daniel F. Hayes
    • 1
    Email author
  1. 1.Department of Internal MedicineBreast Oncology Program of the Comprehensive Cancer Center, University of Michigan Health SystemAnn ArborUSA

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