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Circulating MicroRNAs as Potential Biomarkers for Lung Cancer

  • Sabrina Müller
  • Florian Janke
  • Steffen Dietz
  • Holger SültmannEmail author
Chapter
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 215)

Abstract

Lung cancer is the number one cause of cancer-related mortality worldwide. To improve disease outcome, it is crucial to implement biomarkers into the clinics which assist physicians in their decisions regarding diagnosis, prognosis, as well as prediction of treatment response. Liquid biopsy offers an opportunity to obtain such biomarkers in a minimal invasive manner by retrieving tumor-derived material from body fluids of the patient. The abundance of circulating microRNAs is known to be altered in disease and has therefore been studied extensively as a cancer biomarker. Circulating microRNAs present a variety of favorable characteristics for application as liquid biopsy-based biomarkers, including their high stability, relatively high abundance, and presence is nearly all body fluids. Although the application of circulating microRNAs for the management of lung cancer has not entered the clinics yet, several studies showed their utility for diagnosis, prognosis, and efficacy prediction of various treatment strategies, including surgery, radio-/chemotherapy, as well as targeted therapy. To compensate for their limited tumor specificity, several microRNAs are frequently combined into microRNA panels. Moreover, the possibility to combine single microRNAs or microRNA panels with tumor imaging or other cancer-specific biomarkers has the potential to increase specificity and sensitivity and could lead to the clinical application of novel multi-marker combinations.

Keywords

Circulating microRNA Liquid biopsy Lung cancer NSCLC (Blood-based) biomarker Diagnosis Prognosis Prediction 

Notes

Acknowledgements

We thank Sabine Klauck for critical reading of the manuscript and valuable comments.

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Sabrina Müller
    • 1
  • Florian Janke
    • 1
  • Steffen Dietz
    • 1
  • Holger Sültmann
    • 1
    Email author
  1. 1.Division Cancer Genome Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), and Translational Lung Research Center (TLRC), German Center for Lung Research (DZL)HeidelbergGermany

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