Toddler with Bruising on Knees

  • Farzaneh RahmaniEmail author
  • Nima Rezaei


  • Immune thrombocytopenic purpura (ITP) is commonly preceded by a viral infection, usually a common cold

  • Presence of bone pain, anemia, hepatosplenomegaly or hyperleukocytosis should prompt further investigation using bone marrow aspiration and/or biopsy.

  • Up to 80% of pediatric patients with ITP respond to immunomodulatory therapy with intravenous immunoglobulin in the first therapy course


Immune thrombocytopenic purpura Hepatosplenomegaly Bone marrow aspiration Intravenous immunoglobulin 


  1. 1.
    O’Leary ST, Glanz JM, McClure DL, Akhtar A, Daley MF, Nakasato C, Baxter R, Davis RL, Izurieta HS, Lieu TA, Ball R. The risk of immune thrombocytopenic purpura after vaccination in children and adolescents. Pediatrics. 2012;129(2):248–55.CrossRefGoogle Scholar
  2. 2.
    Kime C, Klima J, Rose MJ, O’Brien SH. Patterns of inpatient care for newly diagnosed immune thrombocytopenia in US children’s hospitals. Pediatrics. 2013;131(5):880–5.CrossRefGoogle Scholar
  3. 3.
    Cuker A, Neunert CE. How I treat refractory immune thrombocytopenia. Blood. 2016;128(12):1547–54.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Student’s Scientific Research Center (SSRC)Tehran University of Medical SciencesTehranIran
  2. 2.NeuroImaging Network (NIN)Universal Scientific Education and Research Network (USERN)TehranIran
  3. 3.Department of Immunology, School of Medicine, Research Center for Immunodeficiencies (RCID), Children’s Medical CenterTehran University of Medical Sciences (TUMS)TehranIran
  4. 4.Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA)Universal Scientific Education and Research Network (USERN)TehranIran

Personalised recommendations