Malaise, Weight Loss and Intermittent Fever

  • Ross Petty
  • Farhad Salehzadeh
  • Marco Antonio Yamazaki-Nakashimada


  • Antibodies against native or double stranded DNA (anti-dsDNA) or extractable nuclear antigens (anti-ENAs) are specific for systemic lupus erythematosus

  • Negative antinuclear antibody (ANA) in children suspected for systemic lupus erythematosus rules out the diagnosis

  • C3, C4 complement level or total hemolytic complement with CH50 give a measure of disease activity in SLE


Anti-double stranded DNA Antinuclear antibody Systemic lupus erythematosus 


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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Ross Petty
    • 1
  • Farhad Salehzadeh
    • 2
  • Marco Antonio Yamazaki-Nakashimada
    • 3
  1. 1.Pediatric RheumatologyUniversity of British ColumbiaVancouverCanada
  2. 2.Pediatric RheumatologyBouali Children’s Hospital, ARUMSArdabilIran
  3. 3.Clinical Immunology DepartmentInstituto Nacional de PediatríaMexico CityMexico

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