Photosensitivity and Bullous Lesions

  • Ashi
  • Piyush Kumar


  • Blisters can rise as a lupus erythematosus specific skin lesion, as bullous systemic lupus erythematosus (BSLE) or due to other associated autoimmune bullous disorders

  • Systemic lupus erythematosus (SLE) can sometimes be associated with other autoimmune bullous diseases such as dermatitis herpetiformis, pemphigus vulgaris, pemphigus foliaceus, bullous pemphigoid

  • Childhood-onset SLE has a worse prognosis compared to adult-onset SLE

  • The most common presenting features for pediatric SLE include fever, nephropathy, and lymphadenopathy

  • Neuropsychiatric features are more prevalent in juvenile-onset SLE compared to adults

  • Cyclophosphamide can permanently alter the ovarian reserve in a dose-, duration- and age- dependent manner

  • The hallmark adverse effect of hydroxychloroquine is retinopathy, which can present insidiously with subtle color vision changes and paracentral scotoma


Bullous systemic lupus erythematosus Childhood-onset SLE Cyclophosphamide Hydroxychloroquine 


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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Ashi
    • 1
  • Piyush Kumar
    • 2
  1. 1.Gauhati Medical CollegeGuwahatiIndia
  2. 2.Department of DermatologyKatihar Medical CollegeKatiharIndia

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