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Recurrent Infections, Diarrhea and Hypereosinophilia

  • Haskologlu Sule
  • Islamoglu Candan
  • Ikinciogullari AydanEmail author
Chapter

Abstract

  • Maternal T cell engrafment has been reported in as many as 40% of newborns with severe combined immunodeficiency (SCID)

  • Hypofunctioning T cells may facilitate persistent engraftment of maternal T lymphocytes, leading to alloreactive immune response referred as graft versus host disease (GVHD). Maternal engraftment syndrome typically present in a neonate/infant as rash and/or diarrhea

  • One indicator that maternal T cell engraftment is present, is predominance of either CD4+ or CD8+ T cells since maternally engrafted cells are oligoclonal. A majority of the maternally engrafted T cells have an activated or memory phenotype and express CD45RO

  • HLA typing, PCR-based short tandem repeat (STR) analysis or fluorescence in-situ hybridization (FISH) analysis, can help detect maternal engrafment syndrome

Keywords

Severe combined immunodeficiency Maternal engraftment syndrome Fluorescence in-situ hybridization CD45RO 

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Haskologlu Sule
    • 1
  • Islamoglu Candan
    • 1
  • Ikinciogullari Aydan
    • 1
    Email author
  1. 1.Department of Pediatric Allergy and ImmunologyAnkara University School of MedicineAnkaraTurkey

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