Acute Dyspnea After Platelet Transfusion

  • Laura CoolingEmail author


  • Transfusion-associated lung injury (TRALI) is defined as the onset of acute, non-cardiogenic pulmonary edema within 6 h of transfusion and the absence of pre-existing acute lung injury

  • Diagnostic findings are hypoxia (O2 saturation < 90% in room air), a PaO2/FiO2 ratio < 300 mmHg and new bilateral pulmonary infiltrates.

  • With O2 supplementation, up to 72% of cases of TRALI resolve within 48–96 h

  • High dose steroids have no benefit in TRALI


Transfusion-associated lung injury Pulmonary edema Acute lung injury FiO2 


  1. 1.
    Kleinman S, Povosky M. TRALI: mechanisms, management and prevention. Bethseda: AABB Press; 2008.Google Scholar
  2. 2.
    Eder A, Dy B, Perez J, Rambaud M, Benjamin R. The residual risk of transfusion-related acute lung injury at the American Red Cross (2008–2011): limitations of a predominantly male-donor plasma mitigation strategy. Transfusion. 2013;53:1442–9.CrossRefGoogle Scholar
  3. 3.
    Nagawa M, Toy P. Acute and transient decrease in neutrophil count in transfusion-related acute lung injury: cases at one hospital. Transfusion. 2004;44:1689–94.CrossRefGoogle Scholar
  4. 4.
    Stein APDV, Alexander P. Antibody-mediated transfusion-related acute lung injury; from discovery to prevention. Br J Haematol. 2015;170:597–614.CrossRefGoogle Scholar
  5. 5.
    Reil A, Keller-Stanislaski B, S SG, Bux JE. Specificities of leucocyte alloantibodies in transfusion-related acute lung injury and results of leucocyte antibody screening of blood donors. Vox Sang. 2008;95:313–7.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of PathologyUniversity of MichiganAnn ArborUSA

Personalised recommendations