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T-Lymphoblastic Lymphoma

  • Soumya Pandey
  • Terry HarvilleEmail author
Chapter

Abstract

  • The highest-resolution HLA typing is thought to provide the best opportunity for matching a patient with a donor in order to reduce the risks for graft-versus host disease (GVHD) and graft rejection

  • Linkage disequilibrium is an important concept regarding HLA type associations, and can be used to help surmise which HLA alleles may be present, while actual typing is typically necessary for confirmation of the results

  • The use of “Common and Well-Documented” alleles is also helpful in determination of the present HLA types

  • Currently, the NMDP does not consider matching for HLA-DRB3, -DRB4, -DRB5, or -DQ to be relevant for hematopoietic cell transplantation (HCT). However, in clinical practice, many transplanters prefer donors matched for these alleles as well

  • HLA-DPB1 is now recognized to be relevant for HCT

  • Matching can occur at two levels; first, the two-field nomenclature match and second, the examination of T cell epitope (TCE) groups for permissive versus non-permissive mismatching of HLA-DPB1

  • Long-term outcomes are similar to those with the HLA-DPB1 two-field nomenclature match and HLA-DPB1 TCE permissive mismatches

  • Cytomegalovirus status match of the patient and donor is a critical factor for successful HCT outcomes

  • The NMDP website provides invaluable information regarding HLA typing and HCT outcomes

Keywords

Graft-versus host disease (GvHD) NMDP Cytomegalovirus HLA-DPB1 

References

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Pathology and Laboratory ServicesUniversity of Arkansas for Medical SciencesLittle RockUSA
  2. 2.Departments of Pediatrics and Internal MedicineUniversity of Arkansas for Medical SciencesLittle RockUSA

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