Linkage Disequilibrium Between HLA Alleles in Hematopoietic Stem Cell Transplantation

  • Soumya Pandey
  • Terry HarvilleEmail author


  • Linkage disequilibrium is the concept that HLA types are associated into inherited haplotypes more commonly than is expected from DNA crossover events, which occur during normal meiosis

  • The distal HLA loci HLA-DP and HLA-A may have some of the greatest chances to undergo crossover exchanges, due to being at the opposite extreme ends of the HLA locus on the short arm of chromosome six

  • If the HLA-A, -B, -C, and -DR are known, then -DQ can be predicted with reasonable accuracy, and likewise if HLA-A, -B, -C, -DR, and -DQ are known, the -DP may be predicted, albeit with somewhat less accuracy


Hematopoietic cell transplantation (HCT) Linkage disequilibrium Cross-over HLA-DP HLA-DQ 


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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Pathology and Laboratory ServicesUniversity of Arkansas for Medical SciencesLittle RockUSA
  2. 2.Departments of Pediatrics and Internal MedicineUniversity of Arkansas for Medical SciencesLittle RockUSA

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