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Suspected Immunodeficiency

  • Soumya Pandey
  • Terry HarvilleEmail author
Chapter

Abstract

  • During pregnancy, the fetus is exposed to the non-inherited maternal HLA haplotype (NIMA, non-inherited maternal antigens)

  • Fetal exposure to NIMA results in generation of tolerance to those HLA components

  • If a related HLA-mismatched donor is all that is available, demonstrating that the mismatched HLA component is a NIMA could predict a successful transplantation

Keywords

Haploidentical Hematopoietic stem cell transplantation Non-inherited maternal antigens HLA 

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Pathology and Laboratory ServicesUniversity of Arkansas for Medical SciencesLittle RockUSA
  2. 2.Departments of Pediatrics and Internal MedicineUniversity of Arkansas for Medical SciencesLittle RockUSA

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