Positive HIV and Violet Macular Rash

  • Tangie Ngek Larry
  • Derrick Tembi Efie


  • Kaposi sarcoma is an AIDS defining, benign tumor of poorly differentiated cell of endothelial origin

  • Kaposi sarcoma is the most common malignancy in patients with HIV

  • Kaposi sarcoma typically appears in skin or oropharynx with persistent initially flat, patches of redish-purpulish color that involute to nodules

  • HHV8 is present in almost all of Kaposi sarcoma lesions

  • Highly active antiretroviral therapy limits or resolves Kaposi sarcoma


Kaposi sarcoma AIDS HHV8 


  1. 1.
    Stanescu L, Foarfa C, Georgescu AC, Georgescu I. Kaposi’s sarcoma associated with AIDS. Roman J Morphol Embryol. 2007;48(2):181–7.Google Scholar
  2. 2.
    Dezube BJ. Clinical presentation and natural history of AIDS-related Kaposi’s sarcoma. Hematol Oncol Clin North Am. 1996;10(5):1023–9.CrossRefGoogle Scholar
  3. 3.
    Cavallin LE, Goldschmidt-Clermont P, Mesri EA. Molecular and cellular mechanisms of KSHV oncogenesis of Kaposi’s sarcoma associated with HIV/AIDS. PLoS Pathog. 2014;10(7):e1004154.CrossRefGoogle Scholar
  4. 4.
    Tappero JW, Berger TG, Kaplan LD, Volberding PA, Kahn JO. Cryotherapy for cutaneous Kaposi’s sarcoma (KS) associated with acquired immune deficiency syndrome (AIDS): a phase II trial. J Acquir Immune Defic Syndr. 1991;4(9):839–46.CrossRefGoogle Scholar
  5. 5.
    Anglemyer A, Agrawal AK, Rutherford GW. Treatment of Kaposi sarcoma in children with HIV-1 infection. Cochrane Database Syst Rev. 2014;(1):CD009826.Google Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Tangie Ngek Larry
    • 1
  • Derrick Tembi Efie
    • 2
    • 3
  1. 1.Faculty of Medicine and Biomedical SciencesUniversity of Yaounde 1YaoundeCameroon
  2. 2.Tokombere District HospitalTokombereCameroon
  3. 3.Health and Human Development Research NetworkDoualaCameroon

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